Quantification strategies for elemental imaging of biological samples using laser ablation-inductively coupled plasma-mass spectrometry

The Analyst ◽  
2012 ◽  
Vol 137 (7) ◽  
pp. 1527 ◽  
Author(s):  
Dominic Hare ◽  
Christine Austin ◽  
Philip Doble
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Biological Samples ◽  
Inductively Coupled Plasma ◽  
Elemental Imaging ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

Evaluation of a custom single Peltier-cooled ablation cell for elemental imaging of biological samples in laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)

2016 ◽  
Vol 31 (4) ◽  
pp. 1030-1033 ◽  
Author(s):  
J. S. Hamilton ◽  
E. L. Gorishek ◽  
P. M. Mach ◽  
D. Sturtevant ◽  
M. L. Ladage ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Biological Samples ◽  
Inductively Coupled Plasma ◽  
Peltier Element ◽  
Elemental Imaging ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Biological Sampling

A new single Peltier element ablation cell is described and its applicability to biological sampling discussed to evaluate its performance.

scholarly journals Elemental imaging of leaves from the metal hyperaccumulating plant Noccaea caerulescens shows different spatial distribution of Ni, Zn and Cd

RSC Advances ◽  
2016 ◽  
Vol 6 (3) ◽  
pp. 2337-2344 ◽  
Author(s):  
Damien L. Callahan ◽  
Dominic J. Hare ◽  
David P. Bishop ◽  
Philip A. Doble ◽  
Ute Roessner
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Elemental Imaging ◽  
Inductively Coupled ◽  
Noccaea Caerulescens ◽  
Plasma Mass Spectrometry ◽  
Hyperaccumulating Plant

Elemental imaging using laser ablation inductively coupled plasma mass spectrometry was performed on whole leaves of the hyperaccumulating plantNoccaea caerulescensafter treatments with either Ni, Zn or Cd.

High spatial resolution quantitative elemental imaging of foraminifer by laser ablation-inductively coupled plasma-mass spectrometry

2019 ◽  
Vol 11 (16) ◽  
pp. 2129-2137 ◽  
Author(s):  
Yuqiu Ke ◽  
Jianzong Zhou ◽  
Lei Qiao ◽  
Muhui Zhang ◽  
Wei Guo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Spatial Resolution ◽  
Inductively Coupled Plasma ◽  
High Spatial Resolution ◽  
Elemental Imaging ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

A methodology for high spatial resolution quantitative elemental imaging of foraminifer by LA-ICP-MS was developed.

Review of the applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to the analysis of biological samples

2014 ◽  
Vol 29 (12) ◽  
pp. 2204-2228 ◽  
Author(s):  
Dirce Pozebon ◽  
Guilherme L. Scheffler ◽  
Valderi L. Dressler ◽  
Matheus A. G. Nunes
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Biological Samples ◽  
Inductively Coupled Plasma ◽  
Life Sciences ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Number Of Publications

Laser ablation inductively coupled plasma mass spectrometry has been proven to be useful in life sciences as can be observed by the increasing number of publications in this field.

Nanoparticles Determination by Laser Ablation Inductively Coupled Plasma Mass Spectrometry

2021 ◽  
Vol 21 (11) ◽  
pp. 5436-5442
Author(s):  
Wenhe Luo ◽  
Tao Li ◽  
Meng Wang ◽  
Wanqin Dai ◽  
Chunlei Jiao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrum ◽  
Laser Ablation ◽  
Biological Samples ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Dissolved Ions ◽  
Plasma Mass Spectrometry ◽  
Signal Profile

Quantitatively studying the biodistribution and transformation of nanomaterials is of great importance for nanotoxicological evaluation. Recently, laser ablation inductively coupled plasma mass spectrometry has been employed to distinguish nanoparticles (NPs) with their dissolved ions in biological samples. The principle of the proposal is based on a hypothesis that the intact NPs sampled by laser ablation will generate discrete sharp pulses of signals in ICP-MS measurement, being totally different from the continuous, relatively lower signals generated by ions. However, it is still a controversy whether NPs could maintain their intactness during the laser ablation. This work found a way to exactly determine the number of NPs sampled for each LA-ICP-MS measurement. It made possible to reveal the signal profile of a single NP in LA-ICP-MS analysis. The results suggest that AuNR, AgNP and TIO2 NP were broken into much smaller secondary NPs during the laser ablation, therefore generating continuous signals in the analyzer. There was a certain probability that the fragmentation of large-sized NP or multiple NPs by laser ablation was not sufficient, leaving some NPs unbroken or some secondary NPs with relatively large sizes to generate discrete pulses of signals in the analyzer. When the intactness of NPs during laser ablation cannot be assured, it is impossible to determine the attribution of mass spectrum signals. These findings compromise the reliability of distinguishing NPs from their dissolved ions by LA-ICP-MS.

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