Novel synthesis of deuteriated derivatives of protoporphyrin-IX

1971 ◽  
pp. 1304 ◽  
Author(s):  
A. M. d'A. Rocha Gonsalves ◽  
G. W. Kenner ◽  
K. M. Smith
Keyword(s):  
Protoporphyrin Ix ◽  
Novel Synthesis ◽  
Derivatives Of

ChemInform Abstract: Novel Synthesis of Calamitic and Discotic Liquid Crystalline Derivatives of Tetrathiafulvalene (TTF).

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
R. A. BISSELL ◽  
N. BODEN ◽  
R. J. BUSHBY ◽  
C. W. G. FISHWICK ◽  
E. HOLLAND ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Novel Synthesis ◽  
Derivatives Of

Pyrazolinyl and cyclopropyl derivatives of protoporphyrin IX and chlorins related to chlorophyll a

Tetrahedron ◽  
2003 ◽  
Vol 59 (4) ◽  
pp. 499-504 ◽  
Author(s):  
Andrei N Kozyrev ◽  
James L Alderfer ◽  
Byron C Robinson
Keyword(s):  
Chlorophyll A ◽  
Protoporphyrin Ix ◽  
Derivatives Of

Molecular Aspects of Herbicide Action on Protoporphyrinogen Oxidase

1993 ◽  
Vol 48 (3-4) ◽  
pp. 326-333 ◽  
Author(s):  
Beate Nicolaus ◽  
Gerhard Sandmann ◽  
Peter Böger
Keyword(s):  
Diphenyl Ether ◽  
Protoporphyrin Ix ◽  
Protoporphyrinogen Oxidase ◽  
Relative Specificity ◽  
Oxidase Inhibition ◽  
Dilution Experiments ◽  
Membrane Bound ◽  
The Common ◽  
Molecular Aspects ◽  
Derivatives Of

Abstract Protoporphyrinogen oxidase, the last enzyme of the common tetrapyrrole biosynthetic pathway, is inhibited by several peroxidizing compounds resulting in accumulation of photodynamic tetrapyrroles, mainly protoporphyrin IX. The inhibition characteristics of two chemi­cally unrelated compounds were studied using membrane bound protoporphyrinogen oxidase from corn etioplasts. As shown by Lineweaver-Burk-analysis, the inhibition of enzyme activity by the diphenyl ether oxyfluorfen and the cyclic imide MCI 15 are competitive with respect to the substrate. The competitive interaction of protoporphyrinogen and the two chemically un­related inhibitors indicate a relative specificity of the binding site. The reversibility of oxyfluorfen inhibition was evaluated by dilution experiments and was shown to be independent of the presence of DTT. The analysis of structure-activity-relationship on protoporphyrinogen oxidase inhibition was investigated with para-substituted derivatives of phenyl-3,4,5,6-tetrahydro-phthalimides. The results obtained by QSAR -calculation yielded a good correlation of the inhibitory activity determined by the lipophilicity of the para-substituent. These data point to one binding region of the inhibitors within a lipophilic environment associated with the active center of the enzyme.

The chemistry of pyrrolic compounds. XIV. meso-Hydroxyprotoporphyrin IX and its derivatives

1970 ◽  
Vol 23 (12) ◽  
pp. 2477 ◽  
Author(s):  
PS Clezy ◽  
AJ Liepa
Keyword(s):  
Protoporphyrin Ix ◽  
Bile Pigment ◽  
General Properties ◽  
Biliverdin Ix ◽  
Hydrolysis Of ◽  
Derivatives Of ◽  
Benzoate Derivatives

The preparation of the acetate and benzoate derivatives of �-hydroxy-protoporphyrin IX is described and the hydrolysis of these enolic esters examined. The general properties of these porphyrins are discussed together with the oxidation of this system to a bile pigment identical with biliverdin IX�: with regard to spectroscopic and chromatographic characteristics.

A Novel Synthesis of Amino Acid Derivatives of Phospholene Oxides.

ChemInform ◽  
2004 ◽  
Vol 35 (42) ◽  
Author(s):  
Buchammagari Haritha ◽  
Valluru Krishna Reddy ◽  
Masaki Takahashi ◽  
Mitsuji Yamashita
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Novel Synthesis ◽  
Derivatives Of

Stereospecific Synthesis of (-)-allo-Muscarine from D-Glucose: Novel Routes to the Key Chiral Synthon

1997 ◽  
Vol 62 (5) ◽  
pp. 809-815 ◽  
Author(s):  
Velimir Popsavin ◽  
Ostoja Beric ◽  
Mirjana Popsavin ◽  
János Csanádi ◽  
Stevan Lajšic ◽  
...  
Keyword(s):  
Mitsunobu Reaction ◽  
Stereospecific Synthesis ◽  
Novel Synthesis ◽  
Derivatives Of ◽  
Chiral Synthon ◽  
Ethylene Acetal

The key chiral synthon in a novel synthesis of (-)-allo-muscarine from D-glucose has been prepared by three independent routes. The most efficient one includes a four-step conversion via the 4-O-benzoyl derivatives of starting 2,5-anhydro-3,5-di-O-methanesulfonyl-L-idose ethylene acetal (2a) into 2,5-anhydro-3,6-dideoxy-L-lyxo-hexose ethylene acetal (4b). The intermediate 4b was efficiently converted into the chiral synthon 2,5-anhydro-4-O-benzoyl-3,6-dideoxy-L-arabino-hexose (4c) by Mitsunobu reaction.

Novel synthesis of nicotinamide derivatives of cytotoxic properties

2006 ◽  
Vol 14 (13) ◽  
pp. 4466-4476 ◽  
Author(s):  
Adel S. Girgis ◽  
Hanaa M. Hosni ◽  
Flora F. Barsoum
Keyword(s):  
Novel Synthesis ◽  
Nicotinamide Derivatives ◽  
Derivatives Of
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