pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism

Soft Matter ◽  
2011 ◽  
Vol 7 (13) ◽  
pp. 6231 ◽  
Author(s):  
Yulin Li ◽  
Dina Maciel ◽  
Helena Tomás ◽  
João Rodrigues ◽  
Hui Ma ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Release Mechanism ◽  
Swelling Behaviour ◽  
Hybrid Hydrogels

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

2015 ◽  
Vol 3 (13) ◽  
pp. 2685-2697 ◽  
Author(s):  
Xinyu Hu ◽  
Wei Wei ◽  
Xiaoliang Qi ◽  
Hao Yu ◽  
Liandong Feng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
Ph Sensitive ◽  
Swelling Behaviour ◽  
Poly Acrylic Acid

The pH-sensitive swelling behaviour and DOX release of Salecan-g-PAA hydrogels are discussed.

scholarly journals pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

2014 ◽  
Vol 50 (1) ◽  
pp. 173-184 ◽  
Author(s):  
Kashif Sohail ◽  
Ikram Ullah Khan ◽  
Yasser Shahzad ◽  
Talib Hussain ◽  
Nazar Muhammad Ranjha
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Phosphate Buffer ◽  
Ph Sensitive ◽  
Cross Linking ◽  
Release Mechanism ◽  
Effect Analysis ◽  
X Ray Crystallography ◽  
Buffer Solutions ◽  
The One

In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels under investigation. Swelling coefficient was high at higher pH values except for the one containing high PVP content. Drug release increased by increasing the pH of the medium and AA contents in hydrogels while increasing the concentration of cross-linking agent had the opposite effect. Analysis of the drug release mechanism revealed non-Fickian transport of tramadol from the hydrogels.

scholarly journals Synthesis and characterization of oral drug delivery, a pH – sensitive silver nanocomposite based on sodium alginate extracted from Sargassum asperifolium collected from Jazan coasts, KSA

2019 ◽  
Author(s):  
Fatimah. A. Agili ◽  
Sahera. F. Mohamed
Keyword(s):  
Electron Microscope ◽  
Drug Release ◽  
Sodium Alginate ◽  
Oral Drug Delivery ◽  
Drug Carrier ◽  
Gastric Fluid ◽  
Ph Sensitive ◽  
Oral Drug ◽  
Release Mechanism ◽  
X Ray

AbstractThe pH-sensitive nanocomposite composed of sodium alginate/ Pectin/ Tannic acid – silver SA/Pec/TA-Ag was prepared using microwave irradiation and employed as a carrier for Propranolol drug. Physico-chemical characteristics of the prepared systems using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), High-Resolution Transmission Electron Microscope (HRTEM), Dynamic light Scattering instrument (DLS), and Energy Dispersive X-Ray Analysis (EDX). The percentage drug release was 96% at pH 7.4 within 420 min. The drug release data was fitted into different kinetic models included zero order, First order, Higuchi and Ritger-Peppas model. The release mechanism is non-Fickian character where it controlled by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is candidate for the oral drug carrier specific for intestinal system and has stability against gastric fluid.

scholarly journals Application of Mesoscale Simulation to Explore the pH Response of Eudragit S100 Used as the Novel Colon-Targeted Powder of Pulsatilla Saponin D

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Mingcheng Gong ◽  
Zhenhua Chen ◽  
Liangliang Zhou ◽  
Feng Gao ◽  
Jianxin Cheng ◽  
...  
Keyword(s):  
Self Assembly ◽  
Morphological Changes ◽  
Drug Carrier ◽  
Dissipative Particle Dynamics ◽  
Ph Sensitive ◽  
The Self ◽  
Coarse Grained ◽  
Release Mechanism ◽  
Eudragit S100 ◽  
Ph Conditions

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research has been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and Eudragit S100, as well as the loading and release mechanism of PSD, was investigated via computer simulations. The effects of the self-assembly characteristics of PSD and Eudragit S100 in the dry powder state on the drug-carrier ratio were explored by the coarse-grained molecular dynamics (CGMD) method. According to the pH-responsive feature of Eudragit S100, the drug protection under gastric pH conditions and release in colonic pH conditions were simulated through the dissipative particle dynamics (DPD) method, which has provided insights into the microscopic morphological changes in the pH-sensitive drug delivery systems.

Physicochemical characterization and release properties of oral drug delivery: A pH-sensitive nanocomposite based on sodium alginate–pectin–tannic acid–silver

2019 ◽  
Vol 28 (8-9) ◽  
pp. 598-608
Author(s):  
Fatimah A Agili ◽  
Sahera FM Aly
Keyword(s):  
Electron Microscope ◽  
Drug Release ◽  
Sodium Alginate ◽  
Tannic Acid ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Diffraction Field ◽  
Oral Drug ◽  
Release Mechanism ◽  
X Ray

A pH-sensitive nanocomposite formed from sodium alginate (SA)/pectin (Pec)/tannic acid (TA)–silver (Ag) was developed using microwave irradiation and it was applied as a carrier for propranolol drug. TA acts as a cross-linker and a reducing agent for Ag ions. Physicochemical characteristics of the fabricated system using Fourier transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscope, high-resolution transmission electron microscope, dynamic light scattering instrument, and energy dispersive X-ray analysis. The swelling percent and the drug release were observed to be pH-sensitive. The occurrence of Ag nanoparticles in the network enhances the drug release that is 96% at pH 7.4 within 420 min. The drug release data were adjusted into different kinetic models involved zero order, first order, Higuchi, and Ritger–Peppas models. The release mechanism is a non-Fickian character where it controls by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is a candidate for the oral drug carrier specific for the intestinal system and has ability against the gastric fluid.

scholarly journals The influence of synthesis parameters on swelling behaviour of pH-sensitive acrylate based hydrogels

2017 ◽  
Vol 58 (4) ◽  
pp. 433-444 ◽  
Author(s):  
Tamara Erceg ◽  
Ivan Ristic ◽  
Suzana Cakic ◽  
Jaroslava Budinski-Simendic
Keyword(s):  
Ph Sensitive ◽  
Swelling Behaviour ◽  
Synthesis Parameters

Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel

2014 ◽  
Vol 194 ◽  
pp. 220-227 ◽  
Author(s):  
Shixian Lv ◽  
Zhaohui Tang ◽  
Dawei Zhang ◽  
Wantong Song ◽  
Mingqiang Li ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Release Mechanism ◽  
Drug Conjugate ◽  
Efficient Delivery

scholarly journals pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 137 ◽  
Author(s):  
Muhammad Rizwan ◽  
Rosiyah Yahya ◽  
Aziz Hassan ◽  
Muhammad Yar ◽  
Ahmad Azzahari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Material Selection ◽  
Ph Sensitive ◽  
Release Mechanism
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