Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents

2011 ◽  
Vol 9 (16) ◽  
pp. 5670 ◽  
Author(s):  
Xuliang Wang ◽  
Yang Li ◽  
Qian Zhao ◽  
Zhenli Min ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antithrombotic Agents ◽  
Design Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

scholarly journals Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid

2008 ◽  
Vol 51 (15) ◽  
pp. 4834-4838 ◽  
Author(s):  
Li Chen ◽  
Yihua Zhang ◽  
Xiangwen Kong ◽  
Edward Lan ◽  
Zhangjian Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oleanolic Acid ◽  
Design Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Design, synthesis and cytotoxic evaluation of nitric oxide-releasing derivatives of isosteviol

2017 ◽  
Vol 90 (3) ◽  
pp. 473-477 ◽  
Author(s):  
Yan Liu ◽  
Tingting Wang ◽  
Yong Ling ◽  
Na Bao ◽  
Wei Shi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Design Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

scholarly journals New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies

2021 ◽  
Vol 139 ◽  
pp. 111678
Author(s):  
Alexandru Sava ◽  
Frederic Buron ◽  
Sylvain Routier ◽  
Alina Panainte ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
In Silico ◽  
In Vitro Studies ◽  
Scaffold Design ◽  
Design Synthesis ◽  
Nitric Oxide Releasing

Novel Nitric Oxide-Releasing Derivatives of Farnesylthiosalicylic Acid: Synthesis and Evaluation of Antihepatocellular Carcinoma Activity

2011 ◽  
Vol 54 (9) ◽  
pp. 3251-3259 ◽  
Author(s):  
Yong Ling ◽  
Xiaolei Ye ◽  
Zhenzhen Zhang ◽  
Yihua Zhang ◽  
Yisheng Lai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acid Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Nitric Oxide-Donating Derivatives of Chrysin Stimulate Angiogenesis and Upregulating VEGF Production

2011 ◽  
Vol 340 ◽  
pp. 363-368 ◽  
Author(s):  
Xiao Qing Zou ◽  
Yong Lan Ding ◽  
Sheng Ming Peng ◽  
Chang Ping Hu ◽  
Han Wu Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Therapeutic Option ◽  
Therapeutic Angiogenesis ◽  
Vegf Mrna ◽  
No Donor ◽  
Endothelial Migration ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Angiogenesis, the development of new capillaries from pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate to form functional vessels. Endothelial dysfunction and decreased nitric oxide bioavailability may underscore the impairment of angiogenesis. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to therapeutic angiogenesis. In this paper, a novel group of hybrid nitric oxide-releasing chrysin derivatives was synthesized. The results indicated that all these chrysin derivatives exhibited promotion of endothelial migration and tubulogenesis in vitro as well as stimulation angiogenesis in vivo.Furthermore, all compounds released NO upon incubation with phosphate buffer at pH 7.4 and enhanced VEGF secretion and VEGF mRNA expression of endothelial cells. These hybrid ester NO donor prodrugs offer a potential drug design concept for the development of therapeutic or preventive agents for angiogenesis deficiency due to ischemic diseases.

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