Novel Nitric Oxide-Releasing Derivatives of Farnesylthiosalicylic Acid: Synthesis and Evaluation of Antihepatocellular Carcinoma Activity

2011 ◽  
Vol 54 (9) ◽  
pp. 3251-3259 ◽  
Author(s):  
Yong Ling ◽  
Xiaolei Ye ◽  
Zhenzhen Zhang ◽  
Yihua Zhang ◽  
Yisheng Lai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acid Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Nitric Oxide-Donating Derivatives of Chrysin Stimulate Angiogenesis and Upregulating VEGF Production

2011 ◽  
Vol 340 ◽  
pp. 363-368 ◽  
Author(s):  
Xiao Qing Zou ◽  
Yong Lan Ding ◽  
Sheng Ming Peng ◽  
Chang Ping Hu ◽  
Han Wu Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Therapeutic Option ◽  
Therapeutic Angiogenesis ◽  
Vegf Mrna ◽  
No Donor ◽  
Endothelial Migration ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Angiogenesis, the development of new capillaries from pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate to form functional vessels. Endothelial dysfunction and decreased nitric oxide bioavailability may underscore the impairment of angiogenesis. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to therapeutic angiogenesis. In this paper, a novel group of hybrid nitric oxide-releasing chrysin derivatives was synthesized. The results indicated that all these chrysin derivatives exhibited promotion of endothelial migration and tubulogenesis in vitro as well as stimulation angiogenesis in vivo.Furthermore, all compounds released NO upon incubation with phosphate buffer at pH 7.4 and enhanced VEGF secretion and VEGF mRNA expression of endothelial cells. These hybrid ester NO donor prodrugs offer a potential drug design concept for the development of therapeutic or preventive agents for angiogenesis deficiency due to ischemic diseases.

Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils

1997 ◽  
Vol 273 (6) ◽  
pp. G1246-G1251 ◽  
Author(s):  
John L. Wallace ◽  
Webb McKnight ◽  
Tammy L. Wilson ◽  
Piero Del Soldato ◽  
Giuseppe Cirino
Keyword(s):  
Nitric Oxide ◽  
Hemorrhagic Shock ◽  
Gastric Damage ◽  
Leukocyte Adherence ◽  
Inhibitory Effects ◽  
Neutrophil Adherence ◽  
Nitric Oxide Releasing ◽  
Derivatives Of ◽  
Ncx 4016

The gastric damage associated with hemorrhagic shock appears to occur, at least in part, through neutrophil-dependent mechanisms. Nitric oxide (NO)-releasing derivatives of aspirin have been shown to spare the gastrointestinal tract of injury. As NO can inhibit neutrophil adherence, it is possible that such a derivative of aspirin (NCX-4016) would exert inhibitory effects on neutrophil adherence and therefore be capable of protecting the stomach against shock-induced gastric damage. This hypothesis was tested in this study. Oral administration of NCX-4016 or glyceryl trinitrate or depletion of circulating neutrophils with antineutrophil serum significantly reduced the extent of gastric damage induced by hemorrhagic shock, whereas aspirin had no effect. NCX-4016 and antineutrophil serum pretreatment resulted in significant preservation of gastric blood flow during the shock period. Moreover, NCX-4016, but not aspirin, was capable of inhibiting N-formyl-Met-Leu-Phe-induced leukocyte adherence to postcapillary mesenteric venules. These results suggest that an NO-releasing aspirin derivative reduces the susceptibility of the stomach to shock-induced damage through inhibitory effects on neutrophil adherence to the vascular endothelium.

scholarly journals Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid

2008 ◽  
Vol 51 (15) ◽  
pp. 4834-4838 ◽  
Author(s):  
Li Chen ◽  
Yihua Zhang ◽  
Xiangwen Kong ◽  
Edward Lan ◽  
Zhangjian Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oleanolic Acid ◽  
Design Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents

2011 ◽  
Vol 21 (14) ◽  
pp. 4210-4214 ◽  
Author(s):  
Yang Li ◽  
Xuliang Wang ◽  
Rong Fu ◽  
Wenying Yu ◽  
Xiaoli Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile

2005 ◽  
Vol 13 (23) ◽  
pp. 6485-6492 ◽  
Author(s):  
George N. Ziakas ◽  
Eleni A. Rekka ◽  
Antonios M. Gavalas ◽  
Phaedra T. Eleftheriou ◽  
Karyofillis C. Tsiakitzis ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tolfenamic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing ◽  
Derivatives Of
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