scholarly journals Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation

2011 ◽  
Vol 40 (10) ◽  
pp. 5068 ◽  
Author(s):  
Seung Hwan Cho ◽  
Ji Young Kim ◽  
Jaesung Kwak ◽  
Sukbok Chang
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Recent advances in transition-metal-catalyzed C–CN bond activations

RSC Advances ◽  
2014 ◽  
Vol 4 (88) ◽  
pp. 47806-47826 ◽  
Author(s):  
Qiaodong Wen ◽  
Ping Lu ◽  
Yanguang Wang
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Cross Coupling ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Bond Activations ◽  
Metal Catalyzed

Recent advances in transition-metal-catalyzed C–CN bond activation, leading to a lot of important approaches such as cyanofunctionalization, cross-coupling and cyanation, are reviewed.

Transition-metal-catalyzed direct β-functionalization of simple carbonyl compounds

2014 ◽  
Vol 1 (7) ◽  
pp. 838-842 ◽  
Author(s):  
Guobing Yan ◽  
Arun Jyoti Borah
Keyword(s):  
Transition Metal ◽  
Carbonyl Compounds ◽  
Bond Activation ◽  
Active Area ◽  
Synthetic Chemistry ◽  
Chemical Transformations ◽  
Recent Advances ◽  
Direct Functionalization ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Chemical transformations via catalytic C–H bond activation have been established as one of the most powerful tools in organic synthetic chemistry. Transition-metal-catalyzed direct functionalization of β-C(sp3)–H bonds of carbonyl compounds has been developed in recent years. This highlight will focus on recent advances in this active area and their mechanisms are also discussed.

scholarly journals Recent advances in the synthesis of bridgehead (or ring-junction) nitrogen heterocycles via transition metal-catalyzed C–H bond activation and functionalization

2020 ◽  
Vol 7 (19) ◽  
pp. 3067-3099
Author(s):  
Biao Nie ◽  
Wanqing Wu ◽  
Yingjun Zhang ◽  
Huanfeng Jiang ◽  
Ji Zhang
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Nitrogen Heterocycles ◽  
Fused Heterocycles ◽  
Recent Advances ◽  
Ring Junction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Bridgehead Nitrogen

An update on recent advances in the synthesis of bridgehead nitrogen fused heterocycles via transition metal-catalyzed C–H activation and functionalization is reported.

Transition metal-catalyzed direct remote C–H functionalization of alkyl groups via C(sp3)–H bond activation

2015 ◽  
Vol 2 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Guanyinsheng Qiu ◽  
Jie Wu
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Recent Advances ◽  
Alkyl Groups ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review is focused on the recent advances in the transition metal-catalyzed direct remote C–H-functionalization of alkyl groups via C(sp3)–H bond activation. In general, carboxamide/ester-chelated β-functionalization reactions are summarized.

Developments in Organocatalyzed C(Ar)- C(Ar) Bond formation Reactions via Single Electron Transfer Mechanism: An Overview

2021 ◽  
Vol 08 ◽  
Author(s):  
Lalit Yadav ◽  
Sandeep Chaudhary
Keyword(s):  
Transition Metal ◽  
Organic Synthesis ◽  
Bond Activation ◽  
Bond Formation ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Metal Free ◽  
Cross Coupling Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

: The formation of new bonds through C-C bond formation is of utmost importance in the synthesis of biologically privileged scaffolds and therapeutic drugs. In recent years, extensive efforts has been done to improve the intermolecular and intramolecular cross-coupling reaction in the simple, mild, efficient, economical, and eco-friendly manner via transition metal-free or organocatalytic direct C-H bond activation methodology. The traditional crosscoupling era continuously shifted to metal-free, organocatalytic, or metal-free cross-dehydrogenative coupling strategies to fast-track the reactions and diminishing the typical purification processes. Therefore, recent advances on the transitionmetal-free, organocatalytic inter- and intra-molecular cross-coupling reactions have been introduced and discussed in the present article. In view of the reaction mechanism, organocatalytic cross-coupling reactions undergo through the radical pathways, radical anionic intermediate which is completely different from traditional transition metal-catalyzed reactions. The exploration of transition metal-free organocatalyzed cross-couplings for direct C-H arylation of arenes has grown significantly, thereby, improving the formation of a wide range of aryl-aryl /aryl-heteroaryl/ heteroaryl-heteroaryl compounds. In the survey, transition metal-free/organocatalytic cross-coupling reactions showed a higher efficiency under simple and mild conditions than the comparative transition metal-catalyzed cross-coupling reactions. However, the higher regioselectivity and chemoselectivity are still far ahead in organocatalytic cross-coupling reactions due to their specific intrinsic mechanistic pathway. The tuning of many parameters such as oxidative states, ligands coordination, and counter anions, etc., which results in the specific direct C-H functionalization with flexible methodology are missing in the transition metal-free cross-coupling reactions. The highly systematic transition metal-catalyzed chemistry is still playing a dominant role over transition metal-free chemistry in organic synthesis. The organocatalyzed transition-metal-free conditions should be more efficient, chemoselective, and regioselective for further potential development and applications in organic synthesis. For the endless pursuit of sustainable chemistry and green chemistry, such transition-metalfree/organocatalytic reactions should be never ceased. Additional curious attention and interest have been developed so far, and chemists are showing their eagerness and talents to uncover the hidden treasure of green chemistry. In this review article, we highlighted the developments of various transition metal-free/organocatalytic C-H bond activation reactions which further encourages the advancement in the development of sustainable C-C coupling reactions and their further applications towards the synthesis of biologically privileged scaffolds and drug molecules.

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