Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres

2011 ◽  
Vol 13 (33) ◽  
pp. 14946 ◽  
Author(s):  
Paulo R. Silva ◽  
Lucas L. R. Vono ◽  
Breno P. Espósito ◽  
Maurício S. Baptista ◽  
Liane M. Rossi
Keyword(s):  
Photodynamic Therapy ◽  
Silica Nanospheres ◽  
Hematoporphyrin Ix

Preparation, Characterization and Phototoxicity of Photosan-Loaded Hollow Silica Nanospheres for Photodynamic Therapy

2012 ◽  
Vol 622-623 ◽  
pp. 930-938
Author(s):  
Xiao Feng Deng ◽  
Yu Wen ◽  
Liang Wu Lin ◽  
Li Xiong ◽  
Xiong Ying Miao
Keyword(s):  
Photodynamic Therapy ◽  
Culture Medium ◽  
Red Light ◽  
Light Dose ◽  
Silica Nanospheres ◽  
Hollow Silica ◽  
One Step ◽  
Wet Chemical ◽  
Hollow Silica Nanospheres ◽  
Phosphate Buffered Saline

In this study, Photosan (PS) was loaded onto hollow silica nanospheres using one-step wet chemical-based synthetic route method. Polydispersive index of the Photosan-loaded hollow Silica Nanospheres (PS-loaded NSs) is 0.121±0.01. The photobiological activity of the PS-loaded NSs was evaluated on human cholangiocarcinoma QBC939 cells. Cells were incubated with free PS or PS-loaded NSs for 2 h and then washed with phosphate-buffered saline. Culture medium was added to the wells containing the cells. Finally, the cells were exposed to red light (630 nm) with a light dose of 10J/cm2. The cellular viability was determined after 24 h of incubation. PS-loaded NSs and free PS eliminated about 96.4%±2.0% and 54.7%±1.9% of QBC939 cells, respectively. The phototoxicity was time dependent up to 2 h and concentration dependent at 1-7.5 mg/l. The cells viability decreased with the increase of the light dose in the range of 5-15 J/cm2. In conclusion, PS-loaded NSs are the release systems that promise photodynamic therapy use.

Early Events in Photodynamic Therapy: Chemical and Physical Changes in a POPC:Cholesterol Bilayer due to Hematoporphyrin IX-mediated Photosensitization

2009 ◽  
Vol 85 (6) ◽  
pp. 1409-1417 ◽  
Author(s):  
António Santos ◽  
António M. Rodrigues ◽  
Abílio J. F. N. Sobral ◽  
Paula V. Monsanto ◽  
Winchil L. C. Vaz ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Physical Changes ◽  
Hematoporphyrin Ix

Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (48) ◽  
pp. 22937-22945 ◽  
Author(s):  
Xiaoli Cai ◽  
Yanan Luo ◽  
Yang Song ◽  
Dong Liu ◽  
Hongye Yan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Three Dimensional ◽  
Silica Nanospheres ◽  
Highly Efficient ◽  
In Situ Formation ◽  
Mitochondria Targeting ◽  
Mesoporous Silica Nanospheres

A mitochondria-targeting and O2-evolving PDT nanoplatform based on 3D-dendritic MSNs was proposed for highly efficient cancer PDT treatment.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

2020 ◽  
Vol 49 (33) ◽  
pp. 11583-11590 ◽  
Author(s):  
Zheng-Yin Pan ◽  
Dai-Hong Cai ◽  
Liang He
Keyword(s):  
Photodynamic Therapy ◽  
Cell Apoptosis ◽  
Lysosomal Dysfunction ◽  
Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

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