A lateral flow biosensor for detection of nucleic acids with high sensitivity and selectivity

2012 ◽  
Vol 48 (2) ◽  
pp. 236-238 ◽  
Author(s):  
Puchang Lie ◽  
Jie Liu ◽  
Zhiyuan Fang ◽  
Boying Dun ◽  
Lingwen Zeng
Keyword(s):  
Nucleic Acids ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Sensitivity And Selectivity

Lateral flow nucleic acid biosensor for Cu2+ detection in aqueous solution with high sensitivity and selectivity

2010 ◽  
Vol 46 (47) ◽  
pp. 9043 ◽  
Author(s):  
Zhiyuan Fang ◽  
Jing Huang ◽  
Puchang Lie ◽  
Zhuo Xiao ◽  
Chuanyan Ouyang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Nucleic Acid ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Sensitivity And Selectivity

Schottky diodes based on 2D materials for environmental gas monitoring: a review on emerging trends, recent developments and future perspectives

2021 ◽  
Author(s):  
Minu Mathew ◽  
Chandra Sekhar Rout
Keyword(s):  
Gas Sensing ◽  
2D Materials ◽  
Schottky Diodes ◽  
High Sensitivity ◽  
Future Perspectives ◽  
Working Temperature ◽  
Emerging Trends ◽  
Gas Sensing Properties ◽  
Recent Developments ◽  
Sensitivity And Selectivity

This review details the fundamentals, working principles and recent developments of Schottky junctions based on 2D materials to emphasize their improved gas sensing properties including low working temperature, high sensitivity, and selectivity.

Lanthanide coordination polymer-based biosensor for citrate detection in urine

2019 ◽  
Vol 11 (10) ◽  
pp. 1405-1409 ◽  
Author(s):  
Haoshuang Shen ◽  
Baoxia Liu ◽  
Daosheng Liu ◽  
Xu Zhu ◽  
Xiuhua Wei ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
High Sensitivity ◽  
Lanthanide Coordination Polymer ◽  
Sensitivity And Selectivity

GMP ligand based LCP sensor for Cit with high sensitivity and selectivity was constructed.

Luminescent nucleotide/Tb3+ coordination polymer for Fe(ii) detection in human serum

2020 ◽  
Vol 12 (8) ◽  
pp. 1122-1130
Author(s):  
Yan Liu ◽  
Lu-Lu Peng ◽  
Wei-Xiong Huang ◽  
Hui-Zhuo Zhou ◽  
Li Xu
Keyword(s):  
Coordination Polymer ◽  
Human Serum ◽  
Adenosine Triphosphate ◽  
High Sensitivity ◽  
Sensitivity And Selectivity ◽  
Bridge Ligand

A luminescent nucleotide/Tb3+ coordination polymer (CP) was synthesized using adenosine triphosphate (ATP) molecules as a bridge ligand and Phen as a sensitizer, which showed high sensitivity and selectivity for Fe2+.

scholarly journals Evaluation of Production Lots of a Rapid Point-of-Care Lateral Flow Serological Test Intended for Identification of IgM and IgG against the N-Terminal Part of the Spike Protein (S1) of SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1043
Author(s):  
Tove Hoffman ◽  
Linda Kolstad ◽  
Bengt Rönnberg ◽  
Åke Lundkvist
Keyword(s):  
Predictive Value ◽  
Serological Test ◽  
Point Of Care ◽  
External Validation ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Spike Protein ◽  
Individual Level ◽  
Lateral Flow Test ◽  
Production Errors

The potential of rapid point-of-care (POC) tests has been subject of doubt due to an eventual risk of production errors. The aim was therefore to evaluate the two separate production lots of a commercial POC lateral flow test, intended for the detection of IgM and IgG against the SARS-CoV-2 spike protein (S1). Control samples consisted of serum from individuals with confirmed SARS-CoV-2 infection and pre-COVID-19 negative sera gathered from a biobank. The presence of anti-S1 IgM/IgG in the sera was verified by an in-house Luminex-based serological assay (COVID-19 SIA). One hundred samples were verified as positive for anti-S1 IgG and 74 for anti-S1 IgM. Two hundred samples were verified as negative for anti-S1 IgM/IgG. For the two lots of the POC-test, the sensitivities were 93.2% and 87.8% for IgM and 93.0% and 100% for IgG. The specificities were 100% for IgM and 99.5% for IgG. The positive predictive value was 100% for IgM and 98.9% and 99.0% for IgG. The negative predictive value was 97.6% and 95.7% for IgM, and 96.6% and 100% for IgG. The evaluated POC-test is suitable to assess anti-SARS-CoV-2 S1 IgM and IgG, as a measure of previous virus exposure on an individual level. The external validation of separate lots of rapid POC-tests is encouraged to ensure high sensitivity before market introduction.

Efficient chemosensors for toxic pollutants based on photoluminescent Zn(II) and Cd(II) metal-organic networks

2021 ◽  
Author(s):  
Luis David Rosales-Vazquez ◽  
Alejandro Dorazco-González ◽  
Victor Sanchez-Mendieta
Keyword(s):  
Optical Sensors ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Environmental Research ◽  
Toxic Pollutants ◽  
Sensitivity And Selectivity ◽  
Metal Organic ◽  
Analytical Tools ◽  
Organic Networks

Optical sensors with high sensitivity and selectivity, as important analytical tools for chemical and environmental research, can be accomplished by straightforward synthesis of luminescent one-, two- and three-dimensional Zn(II) and...

scholarly journals Integrating high-performing electrochemical transducers in lateral flow assay

2021 ◽  
Author(s):  
Antonia Perju ◽  
Nongnoot Wongkaew
Keyword(s):  
High Performance ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Analytical Performance ◽  
Label Free ◽  
High Performing ◽  
Lateral Flow Assays ◽  
Electrochemical Transducers

AbstractLateral flow assays (LFAs) are the best-performing and best-known point-of-care tests worldwide. Over the last decade, they have experienced an increasing interest by researchers towards improving their analytical performance while maintaining their robust assay platform. Commercially, visual and optical detection strategies dominate, but it is especially the research on integrating electrochemical (EC) approaches that may have a chance to significantly improve an LFA’s performance that is needed in order to detect analytes reliably at lower concentrations than currently possible. In fact, EC-LFAs offer advantages in terms of quantitative determination, low-cost, high sensitivity, and even simple, label-free strategies. Here, the various configurations of EC-LFAs published are summarized and critically evaluated. In short, most of them rely on applying conventional transducers, e.g., screen-printed electrode, to ensure reliability of the assay, and additional advances are afforded by the beneficial features of nanomaterials. It is predicted that these will be further implemented in EC-LFAs as high-performance transducers. Considering the low cost of point-of-care devices, it becomes even more important to also identify strategies that efficiently integrate nanomaterials into EC-LFAs in a high-throughput manner while maintaining their favorable analytical performance.

Gold nanorods-based lateral flow biosensors for sensitive detection of nucleic acids

2021 ◽  
Vol 188 (4) ◽  
Author(s):  
Qingcai Yu ◽  
Jing Zhang ◽  
Wanwei Qiu ◽  
Kun Li ◽  
Lisheng Qian ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Gold Nanorods ◽  
Lateral Flow ◽  
Sensitive Detection
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