Graphene-Prussian blue/gold nanoparticles based electrochemical immunoassay of carcinoembryonic antigen

2011 ◽  
Vol 3 (9) ◽  
pp. 2082 ◽  
Author(s):  
Guangfeng Wang ◽  
Ge Zhang ◽  
Hao Huang ◽  
Lun Wang
Keyword(s):  
Gold Nanoparticles ◽  
Carcinoembryonic Antigen ◽  
Prussian Blue ◽  
Electrochemical Immunoassay

Electrochemical immunoassay of carcinoembryonic antigen based on TiO2–graphene / thionine / gold nanoparticles composite

2012 ◽  
Vol 90 (7) ◽  
pp. 608-615 ◽  
Author(s):  
Ke-Jing Huang ◽  
Zhi-Wei Wu ◽  
Ying-Ying Wu ◽  
Yan-Ming Liu
Keyword(s):  
Gold Nanoparticles ◽  
Carcinoembryonic Antigen ◽  
Linear Response ◽  
Multilayer Film ◽  
Electrostatic Force ◽  
Carbon Electrode ◽  
Electrochemical Immunoassay ◽  
Amino Groups ◽  
Amperometric Immunosensor ◽  
Highly Sensitive

A novel multilayer film based on gold nanoparticles (AuNPs), thionine (Thi), and TiO2–graphene (TiO2–Gr) was exploited to develop a highly sensitive amperometric immunosensor for detecting carcinoembryonic antigen (CEA). Firstly, Nafion–TiO2–Gr homogeneous composite was dropped on the surface of a glassy carbon electrode (GCE). Then Thi was chemisorbed by the TiO2–Gr–Nafion composite. Furthermore, the negative ly charged AuNPs were chemisorbed onto Thi film through the electrostatic force with the amino groups of Thi. Cyclic voltammetry (CV) was employed to characterize the assembly process and the performance of the immunosensor. Because of the synergistic effect of the AuNPs, Thi, and the unique properties of TiO2–Gr, the obtained immunosensor exhibited a wide linear response to CEA in two ranges from 0.1 to 10.0 ng mL−1 and from 10.0 to 120.0 ng mL−1 with a relatively low detection limit of 0.01 ng mL−1 (S/N = 3), as well as good stability and repeatability.

Novel Electrochemical Immunoassay for Carcinoembryonic Antigen Using Ferrocenyl Polymer Nanospheres

2016 ◽  
Vol 49 (18) ◽  
pp. 2931-2942 ◽  
Author(s):  
Yanling Zhao ◽  
Ruiping Zhang ◽  
Hui Zhang ◽  
Xianmei Xie
Keyword(s):  
Carcinoembryonic Antigen ◽  
Electrochemical Immunoassay ◽  
Polymer Nanospheres
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