Comparison of electrode materials for the detection of rapid hydrogen peroxide fluctuations using background-subtracted fast scan cyclic voltammetry

The Analyst ◽  
2011 ◽  
Vol 136 (17) ◽  
pp. 3550 ◽  
Author(s):  
James G. Roberts ◽  
Keri L. Hamilton ◽  
Leslie A. Sombers
Keyword(s):  
Hydrogen Peroxide ◽  
Cyclic Voltammetry ◽  
Electrode Materials ◽  
Fast Scan Cyclic Voltammetry

scholarly journals Design Choices for Next-Generation Neurotechnology Can Impact Motion Artifact in Electrophysiological and Fast-Scan Cyclic Voltammetry Measurements

Micromachines ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 494 ◽  
Author(s):  
Evan Nicolai ◽  
Nicholas Michelson ◽  
Megan Settell ◽  
Seth Hara ◽  
James Trevathan ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Electrode Materials ◽  
Motion Artifact ◽  
Next Generation ◽  
Fast Scan Cyclic Voltammetry ◽  
Flexible Electrodes ◽  
In Vivo Experiments ◽  
Electrophysiological Recordings

Implantable devices to measure neurochemical or electrical activity from the brain are mainstays of neuroscience research and have become increasingly utilized as enabling components of clinical therapies. In order to increase the number of recording channels on these devices while minimizing the immune response, flexible electrodes under 10 µm in diameter have been proposed as ideal next-generation neural interfaces. However, the representation of motion artifact during neurochemical or electrophysiological recordings using ultra-small, flexible electrodes remains unexplored. In this short communication, we characterize motion artifact generated by the movement of 7 µm diameter carbon fiber electrodes during electrophysiological recordings and fast-scan cyclic voltammetry (FSCV) measurements of electroactive neurochemicals. Through in vitro and in vivo experiments, we demonstrate that artifact induced by motion can be problematic to distinguish from the characteristic signals associated with recorded action potentials or neurochemical measurements. These results underscore that new electrode materials and recording paradigms can alter the representation of common sources of artifact in vivo and therefore must be carefully characterized.

scholarly journals Spontaneous Formation of Melanin from Dopamine in the Presence of Iron

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1285
Author(s):  
David M. Hedges ◽  
Jordan T. Yorgason ◽  
Andrew W. Perez ◽  
Nathan D. Schilaty ◽  
Benjamin M. Williams ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Hydrogen Peroxide ◽  
Cyclic Voltammetry ◽  
Brain Slices ◽  
Fast Scan Cyclic Voltammetry ◽  
Spontaneous Formation ◽  
Ir Spectrophotometry ◽  
Da Release

Parkinson’s disease is associated with degeneration of neuromelanin (NM)-containing substantia nigra dopamine (DA) neurons and subsequent decreases in striatal DA transmission. Dopamine spontaneously forms a melanin through a process called melanogenesis. The present study examines conditions that promote/prevent DA melanogenesis. The kinetics, intermediates, and products of DA conversion to melanin in vitro, and DA melanogenesis under varying levels of Fe3+, pro-oxidants, and antioxidants were examined. The rate of melanogenesis for DA was substantially greater than related catecholamines norepinephrine and epinephrine and their precursor amino acids tyrosine and l-Dopa as measured by UV-IR spectrophotometry. Dopamine melanogenesis was concentration dependent on the pro-oxidant species and Fe3+. Melanogenesis was enhanced by the pro-oxidant hydrogen peroxide (EC50 = 500 μM) and decreased by the antioxidants ascorbate (IC50 = 10 μM) and glutathione (GSH; IC50 = 5 μM). Spectrophotometric results were corroborated by tuning a fast-scan cyclic voltammetry system to monitor DA melanogenesis. Evoked DA release in striatal brain slices resulted in NM formation that was prevented by GSH. These findings suggest that DA melanogenesis occurs spontaneously under physiologically-relevant conditions of oxidative stress and that NM may act as a marker of past exposure to oxidative stress.

scholarly journals Carbon Nanotube Yarn Microelectrodes Promote High Temporal Measurements of Serotonin Using Fast Scan Cyclic Voltammetry

Sensors ◽  
2020 ◽  
Vol 20 (4) ◽  
pp. 1173 ◽  
Author(s):  
Alexander Mendoza ◽  
Thomas Asrat ◽  
Favian Liu ◽  
Pauline Wonnenberg ◽  
Alexander G. Zestos
Keyword(s):  
Electron Transfer ◽  
Cyclic Voltammetry ◽  
Carbon Nanotube ◽  
Electrode Materials ◽  
Cyclic Voltammograms ◽  
Electron Transfer Kinetics ◽  
Fast Scan Cyclic Voltammetry ◽  
Peak Separation ◽  
Aspect Ratios ◽  
Carbon Fiber Microelectrodes

Carbon fiber-microelectrodes (CFMEs) have been the standard for neurotransmitter detection for over forty years. However, in recent years, there have been many advances of utilizing alternative nanomaterials for neurotransmitter detection with fast scan cyclic voltammetry (FSCV). Recently, carbon nanotube (CNT) yarns have been developed as the working electrode materials for neurotransmitter sensing capabilities with fast scan cyclic voltammetry. Carbon nanotubes are ideal for neurotransmitter detection because they have higher aspect ratios enabling monoamine adsorption and lower limits of detection, faster electron transfer kinetics, and a resistance to surface fouling. Several methods to modify CFMEs with CNTs have resulted in increases in sensitivity, but have also increased noise and led to irreproducible results. In this study, we utilize commercially available CNT-yarns to make microelectrodes as enhanced neurotransmitter sensors for neurotransmitters such as serotonin. CNT-yarn microelectrodes have significantly higher sensitivities (peak oxidative currents of the cyclic voltammograms) than CFMEs and faster electron transfer kinetics as measured by peak separation (ΔEP) values. Moreover, both serotonin and dopamine are adsorption controlled to the surface of the electrode as measured by scan rate and concentration experiments. CNT yarn microelectrodes also resisted surface fouling of serotonin onto the surface of the electrode over thirty minutes and had a wave application frequency independent response to sensitivity at the surface of the electrode.

scholarly journals Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry

2013 ◽  
Vol 4 (5) ◽  
pp. 782-789 ◽  
Author(s):  
Marina Spanos ◽  
Julie Gras-Najjar ◽  
Jeremy M. Letchworth ◽  
Audrey L. Sanford ◽  
J. Vincent Toups ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cyclic Voltammetry ◽  
Dorsal Striatum ◽  
Fast Scan Cyclic Voltammetry

Study on the Electrochemical Behavior of Ferric Stearate and its Electro-Catalytic Oxidation of Hydrogen Peroxide

2009 ◽  
Vol 610-613 ◽  
pp. 161-164
Author(s):  
Li Li Liang ◽  
Xue Gang Luo ◽  
Xiao Yan Lin
Keyword(s):  
Hydrogen Peroxide ◽  
Cyclic Voltammetry ◽  
Catalytic Oxidation ◽  
Tin Oxide ◽  
Electrochemical Behavior ◽  
Doctor Blade ◽  
Conductive Glass ◽  
Oxidation Of Hydrogen ◽  
Electro Catalytic Oxidation ◽  
Catalytic Effects

A ferric stearate electrode was made by doctor-blade methods using the Fluorine tin oxide (FTO) conductive glass. The electrochemical behavior of ferric stearate electrode was studied by the cyclic voltammetry. The electro-catalytic effects of ferric stearate on H2O2 were also investigated by cyclic voltammetry.

Carbon Fiber Multielectrode Array (CFMEA) for Multiplexing Neurochemical Measurements with Fast Scan Cyclic Voltammetry

2021 ◽  
Vol MA2021-02 (55) ◽  
pp. 1606-1606
Author(s):  
Alexander George Zestos ◽  
Favian Alberto Liu ◽  
Thomas Asrat ◽  
Harmain Rafi
Keyword(s):  
Cyclic Voltammetry ◽  
Carbon Fiber ◽  
Multielectrode Array ◽  
Fast Scan Cyclic Voltammetry

A Two-step Electrodeposition of Pd-Cu/Cu2O Nanocomposite on FTO Substrate for Non-enzymatic Hydrogen Peroxide Sensor

2021 ◽  
Vol 17 ◽  
Author(s):  
Ke Huan ◽  
Li Tang ◽  
Dongmei Deng ◽  
Huan Wang ◽  
Xiaojing Si ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cyclic Voltammetry ◽  
Photoelectron Spectroscopy ◽  
Chemical Structure ◽  
Pd Nanoparticles ◽  
Optimal Conditions ◽  
Potential Oscillation ◽  
X Ray Diffraction ◽  
X Ray

Background: Hydrogen peroxide (H2O2) is a common reagent in the production and living, but excessive H2O2 may enhance the danger to the human body. Consequently, it is very important to develop economical, fast and accurate techniques for detecting H2O2. Methods: A simple two-step electrodeposition process was applied to synthesize Pd-Cu/Cu2O nanocomposite for non-enzymatic H2O2 sensor. Cu/Cu2O nanomaterial was firstly electrodeposited on FTO by potential oscillation technique, and then Pd nanoparticles were electrodeposited on Cu/Cu2O nanomaterial by cyclic voltammetry. The chemical structure, component, and morphology of the synthesized Pd-Cu/Cu2O nanocomposite were characterized by X-ray diffraction, scanning electron microscopy and X-ray photoelectron spectroscopy. The electrochemical properties of Pd-Cu/Cu2O nanocomposite were studied by cyclic voltammetry and amperometry. Results: Under optimal conditions, the as-fabricated sensor displayed a broad linear range (5-4000 µM) and low detection limit (1.8 µM) for the determination of H2O2. The proposed sensor showed good selectivity and reproducibility. Meanwhile, the proposed sensor has been successfully applied to detect H2O2 in milk. Conclusion: The Pd-Cu/Cu2O/FTO biosensor exhibits excellent electrochemical activity for H2O2 reduction, which has great potential application in the field of food safety.

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