Highly efficient processing of silk fibroin nanoparticle-l-asparaginase bioconjugates and their characterization as a drug delivery system

Soft Matter ◽  
2011 ◽  
Vol 7 (20) ◽  
pp. 9728 ◽  
Author(s):  
Yu-Qing Zhang ◽  
Yuan-Jing Wang ◽  
Hai-Yan Wang ◽  
Lin Zhu ◽  
Zhen-Zhen Zhou
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Highly Efficient ◽  
Efficient Processing

Macromolecular HPMA-Based Nanoparticles with Cholesterol for Solid-Tumor Targeting: Detailed Study of the Inner Structure of a Highly Efficient Drug Delivery System

2012 ◽  
Vol 13 (8) ◽  
pp. 2594-2604 ◽  
Author(s):  
Sergey K. Filippov ◽  
Petr Chytil ◽  
Petr V. Konarev ◽  
Margarita Dyakonova ◽  
ChristineM. Papadakis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Tumor ◽  
Tumor Targeting ◽  
Highly Efficient

Silk fibroin nanoparticle as a novel drug delivery system

2015 ◽  
Vol 206 ◽  
pp. 161-176 ◽  
Author(s):  
Fatemeh Mottaghitalab ◽  
Mehdi Farokhi ◽  
Mohammad Ali Shokrgozar ◽  
Fatemeh Atyabi ◽  
Hossein Hosseinkhani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Novel Drug Delivery System ◽  
Novel Drug

Preparation of Crosslinked Chitosan/Silk Fibroin Blend Films for Drug Delivery System

2003 ◽  
Vol 3 (10) ◽  
pp. 604-611 ◽  
Author(s):  
Ratana Rujiravanit ◽  
Sopon Kruaykitanon ◽  
Alexander M. Jamieson ◽  
Seiichi Tokura
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Blend Films ◽  
Crosslinked Chitosan

scholarly journals PREPARATION AND CHARACTERIZATION OF CHITOSAN/REGENERATED SILK FIBROIN (CS/RSF) FILMS AS A BIOMATERIAL FOR CONTACT LENSES-BASED OPHTHALMIC DRUG DELIVERY SYSTEM

2019 ◽  
pp. 275-284 ◽  
Author(s):  
RACHASIT JEENCHAM ◽  
MANOTE SUTHEERAWATTANANONDA ◽  
Waree Tiyaboonchai
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Water Content ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Regenerated Silk Fibroin ◽  
Ophthalmic Drug

Objective: The aim of this study was to develop chitosan/regenerated silk fibroin (CS/RSF) films as a biomaterial for contact lenses-based ophthalmic drug delivery system. Methods: CS/RSF films were prepared with polyethylene glycol 400 as a plasticizer by using a film casting technique. Their physicochemical properties were investigated by measuring various properties such as thickness, morphology, chemical interaction, light transparency, mechanical properties, water content, oxygen permeability, thermal properties and enzyme degradation. In addition, cytotoxicity was also studied. Results: At optimal preparation conditions, CS/RSF films showed smooth surfaces with highly visible light transparency of >90%, which meet the visual requirement. CS/RSF films showed high water content, 59-65% by weight, and their Young’s modulus and elongation at break was in the range of 3.8-6 N/mm2 and 113-135%, respectively. The CS/RSF films also could be sterilized by autoclave method as they possessed high thermal decomposition temperature of >260 °C which can be confirmed by both differential scanning calorimetry and thermogravimetric analysis. In addition, CS/RSF films showed no degradation in stimulated tear fluid containing lysozyme for 7 d and showed no cytotoxicity by MTT assay. Conclusion: CS/RSF films showed excellent physicochemical properties and non-cytotoxicity indicating their promising potential use as a biomaterial for contact lenses-based ophthalmic drug delivery system.

Dual drug delivery system based on pH-sensitive silk fibroin/alginate nanoparticles entrapped in PNIPAM hydrogel for treating severe infected burn wound

2020 ◽  
Vol 13 (1) ◽  
pp. 015005
Author(s):  
Fatemeh Rezaei ◽  
Sheyda Damoogh ◽  
Rui L Reis ◽  
Subhas C Kundu ◽  
Fatemeh Mottaghitalab ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Ph Sensitive ◽  
Burn Wound ◽  
Dual Drug
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