Preparation of Crosslinked Chitosan/Silk Fibroin Blend Films for Drug Delivery System

2003 ◽  
Vol 3 (10) ◽  
pp. 604-611 ◽  
Author(s):  
Ratana Rujiravanit ◽  
Sopon Kruaykitanon ◽  
Alexander M. Jamieson ◽  
Seiichi Tokura
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Blend Films ◽  
Crosslinked Chitosan

Silk fibroin nanoparticle as a novel drug delivery system

2015 ◽  
Vol 206 ◽  
pp. 161-176 ◽  
Author(s):  
Fatemeh Mottaghitalab ◽  
Mehdi Farokhi ◽  
Mohammad Ali Shokrgozar ◽  
Fatemeh Atyabi ◽  
Hossein Hosseinkhani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals Characteristic of ascorbic acid in crosslinked chitosan edible film as drug delivery system membrane

2018 ◽  
Vol 154 ◽  
pp. 01027 ◽  
Author(s):  
Lilis Kistriyani ◽  
Wahyu Sulistyawan ◽  
Sapta Hadi Kesuma
Keyword(s):  
Drug Delivery ◽  
Ascorbic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Spectrophotometric Analysis ◽  
Common Type ◽  
Edible Film ◽  
Microbial Properties ◽  
Crosslinked Chitosan

Chitosan is a polysaccharide compound in the form of a linear polysaccharide consisting of N-acetyl glucosamine (GlcNAc) and D-glucosamine (GlcN) monomer, which is a derivative of deacetylization of chitin polymer. Chitin is one of common type of polysaccharide on earth after the excess cellulose from inveterbrata skeletons. Chitosan has anti-microbial properties. Based on this properties, chitosan is potentially used to be an edible film as drug delivery system membrane. Edible film was made by dissolving chitosan in 100 mL acetic acid 1%, then the plasticizer and crosslinker was added while heated at 60° C. It was molded and dried in oven at 50°C for 48 hours. Drug loading in the edible film could be controlled by remodeling membrane characteristics in the presence of crosslinker additions. The purpose of this study was to estimate the mass transfer coefficient (kCa) of drug loading in various concentrations of ascorbic acid in the edible film. The characteristics of ascorbic acid in chitosan edible film could be seen from the number of drugs that could be loaded through the uv-vis spectrophotometric analysis. The higher concentration of ascorbic acid was added, the drug would be loaded more into edible film.

scholarly journals PREPARATION AND CHARACTERIZATION OF CHITOSAN/REGENERATED SILK FIBROIN (CS/RSF) FILMS AS A BIOMATERIAL FOR CONTACT LENSES-BASED OPHTHALMIC DRUG DELIVERY SYSTEM

2019 ◽  
pp. 275-284 ◽  
Author(s):  
RACHASIT JEENCHAM ◽  
MANOTE SUTHEERAWATTANANONDA ◽  
Waree Tiyaboonchai
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Water Content ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Regenerated Silk Fibroin ◽  
Ophthalmic Drug

Objective: The aim of this study was to develop chitosan/regenerated silk fibroin (CS/RSF) films as a biomaterial for contact lenses-based ophthalmic drug delivery system. Methods: CS/RSF films were prepared with polyethylene glycol 400 as a plasticizer by using a film casting technique. Their physicochemical properties were investigated by measuring various properties such as thickness, morphology, chemical interaction, light transparency, mechanical properties, water content, oxygen permeability, thermal properties and enzyme degradation. In addition, cytotoxicity was also studied. Results: At optimal preparation conditions, CS/RSF films showed smooth surfaces with highly visible light transparency of >90%, which meet the visual requirement. CS/RSF films showed high water content, 59-65% by weight, and their Young’s modulus and elongation at break was in the range of 3.8-6 N/mm2 and 113-135%, respectively. The CS/RSF films also could be sterilized by autoclave method as they possessed high thermal decomposition temperature of >260 °C which can be confirmed by both differential scanning calorimetry and thermogravimetric analysis. In addition, CS/RSF films showed no degradation in stimulated tear fluid containing lysozyme for 7 d and showed no cytotoxicity by MTT assay. Conclusion: CS/RSF films showed excellent physicochemical properties and non-cytotoxicity indicating their promising potential use as a biomaterial for contact lenses-based ophthalmic drug delivery system.

Highly efficient processing of silk fibroin nanoparticle-l-asparaginase bioconjugates and their characterization as a drug delivery system

Soft Matter ◽  
2011 ◽  
Vol 7 (20) ◽  
pp. 9728 ◽  
Author(s):  
Yu-Qing Zhang ◽  
Yuan-Jing Wang ◽  
Hai-Yan Wang ◽  
Lin Zhu ◽  
Zhen-Zhen Zhou
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Highly Efficient ◽  
Efficient Processing

Dual drug delivery system based on pH-sensitive silk fibroin/alginate nanoparticles entrapped in PNIPAM hydrogel for treating severe infected burn wound

2020 ◽  
Vol 13 (1) ◽  
pp. 015005
Author(s):  
Fatemeh Rezaei ◽  
Sheyda Damoogh ◽  
Rui L Reis ◽  
Subhas C Kundu ◽  
Fatemeh Mottaghitalab ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Ph Sensitive ◽  
Burn Wound ◽  
Dual Drug

Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

2016 ◽  
Vol 167 ◽  
pp. 175-178 ◽  
Author(s):  
Maobin Xie ◽  
Yi Li ◽  
Zheng Zhao ◽  
Aizheng Chen ◽  
Jiashen Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Supercritical Co2
Sign in / Sign up

Export Citation Format

Share Document