Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

2011 ◽  
Vol 2 (2) ◽  
pp. 323-327 ◽  
Author(s):  
Hongmei Li ◽  
Abhijeet P. Bapat ◽  
Ming Li ◽  
Brent S. Sumerlin
2016 ◽  
Vol 7 (47) ◽  
pp. 7242-7248 ◽  
Author(s):  
Zhiyue Zhang ◽  
Nane Vanparijs ◽  
Stef Vandewalle ◽  
Filip E. Du Prez ◽  
Lutz Nuhn ◽  
...  

We report on the synthesis of amine-reactive polymers, for the purpose of protein conjugation.


In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems outstanding at the time of publication of this earlier work have now been, for the most part, solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers not only the essential procedures for the production of linear peptides but also more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly and a survey of available automated instrumentation.


2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Phillip Gibson ◽  
Heidi Schreuder-Gibson ◽  
Pearl Yip ◽  
Brendan Denker ◽  
Hamid Benaddi ◽  
...  

The role of water in protective fabrics is critical to comfort and material performance. Excessive perspiration in clothing causes discomfort, and bound water can adversely affect the ability of carbon to adsorb chemicals. Yet the presence of water can also improve the moisture vapor transport of protective polymer films, and is essential for the hydrolytic destruction of nerve agents. Reported here are the findings of wicking and drying experiments conducted on various hydrophilic and hydrophobic cover fabrics that demonstrate the influence of wetting on permeation through fabrics. The influence of water content on reactive polymers capable of degrading nerve agent simulant is also discussed, and the importance of a novel “delivery system” for water to the reactive components through the use of a wicking fabric is introduced.


1981 ◽  
Vol 26 (10) ◽  
pp. 3205-3211 ◽  
Author(s):  
D. Horák ◽  
Z. Pelzbauer ◽  
F. Ŝvec ◽  
J. Kálal
Keyword(s):  

1984 ◽  
Vol 16 (4) ◽  
pp. 193-198 ◽  
Author(s):  
Jean M. J. Fréchet ◽  
Marina Vivas de Meftahi

Sign in / Sign up

Export Citation Format

Share Document