{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM): Its anti-cancer efficacy and intercalation mechanism identified via multi-model systems

2011 ◽  
Vol 7 (3) ◽  
pp. 766-772 ◽  
Author(s):  
Wenjing Wang ◽  
Ming Zhao ◽  
Yuji Wang ◽  
Jiawang Liu ◽  
Jianhui Wu ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Acid Methyl Ester ◽  
Model Systems ◽  
Methyl Ethyl ◽  
Acid Methyl ◽  
Anti Cancer

scholarly journals {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3

2015 ◽  
Vol 2015 ◽  
pp. 1-10
Author(s):  
Ye Li ◽  
Wenjing Wang ◽  
Xiaoxue Xu ◽  
Shiyue Sun ◽  
Xiaoyu Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Acetic Acid ◽  
Methyl Ester ◽  
Acid Methyl Ester ◽  
High Sensitivity ◽  
Inhibitory Effect ◽  
Methyl Ethyl ◽  
Nadph Oxidase 4 ◽  
Acid Methyl ◽  
Cellular Reactive Oxygen Species

{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) is a novel indole compound, which possessed high efficacy against many cancers xenografted in mice without obvious toxicity. In this study, we aimed to investigate the effects of MIAM on human hepatocellular carcinoma (HCC) Bel-7402 cells and its resistant variants Bel-7402/5FU. MIAM inhibited the growth of HCC more potent in Bel-7402/5FU cells than its parent cells. MIAM increased cellular reactive oxygen species (ROS) levels, induced cell apoptosis, and arrested cell cycle in G0/G1phase. MIAM might exert its action on Bel-7402/5FU cells through activation of NADPH oxidase 4 (NOX4)/p22, Sirtuin3 (SIRT3)/SOD2, and SIRT3/p53/p21pathways. MIAM might inhibit HCC growth through the modulation of SIRT3. When SIRT3 was silenced, the inhibitory effect of MIAM on Bel-7402/5FU was lowered, showing the characteristic of resistance against MIAM, whereas Bel-7402/5FU cells with high expression of SIRT3 by SIRT3 adenovirus infection demonstrated the high sensitivity to MIAM. These results suggested that MIAM might exert its action against Bel-7402/5FU growth through upregulation of SIRT3. We suggested that MIAM might be a promising candidate compound which could develop as a potent anticancer agent targeting NOX4 and SIRT3 activation.

Synthesen von Heterocyclen, CCIV1 Reaktionen mit cyclischen Oxalylverbindungen, XIX2 Eine einfache Synthese von 5-Benzoyl-6-phenyl-1.3-dioxin-4-onen / Syntheses of Heterocycles, CCIV1 Reactions of Cyclic Oxalyl Compounds, XIX 2 A Simple Synthesis of 5 Benzoyl-6-phenyl-1,3-dioxin-4-ones

1977 ◽  
Vol 32 (6) ◽  
pp. 701-704 ◽  
Author(s):  
Gert Kollenz ◽  
Erich Ziegler ◽  
Walter Ott ◽  
Gert Kriwetz
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Acrylic Acid ◽  
Acid Methyl Ester ◽  
The Other ◽  
Simple Synthesis ◽  
Acid Methyl ◽  
Other Hand

4-Benzoyl-5-phenyl-2,3-dihydrofuran-2,3-dione (1) reacts with aldehydes or ketones via the acylketene-intermediate (2) yielding the 1,3-dioxin-4-ones (3). The aldehyde derivatives (3 a-e) can be converted into the anilino-chalcone (5) or the anilino acrylic acid (6) by treating with aniline at 20 °C. 6 and diazomethane combine to the acrylic acid methyl ester (7), which by heating (200 °C) is cyclisized to the quinolin-4-ole (8). On the other hand, the keto derivatives 3f-h and aniline give the dibenzoyl acetic acid anilide (9).

scholarly journals Synthesis, characterization and properties of a copper complex with dicyano acetic acid methyl ester ligand derived from tetracyanoethylene

Polyhedron ◽  
2017 ◽  
Vol 121 ◽  
pp. 13-18 ◽  
Author(s):  
Chen-Neng Lin ◽  
Ling-Zhi Tang ◽  
Shi-Tao Ren ◽  
Li-Ping Ye ◽  
Cai-Hong Chen ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Methyl Ester ◽  
Copper Complex ◽  
Acid Methyl Ester ◽  
Acid Methyl
Sign in / Sign up

Export Citation Format

Share Document