Polymeric micelles using pseudo-amphiphilic block copolymers and their cellular uptake

2011 ◽  
Vol 21 (8) ◽  
pp. 2555 ◽  
Author(s):  
Massimo Benaglia ◽  
Angelo Alberti ◽  
Enzo Spisni ◽  
Alessio Papi ◽  
Emanuele Treossi ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Cellular Uptake ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers

scholarly journals Amphiphilic block copolymers enhance the cellular uptake of DNA molecules through a facilitated plasma membrane transport

2010 ◽  
Vol 39 (4) ◽  
pp. 1610-1622 ◽  
Author(s):  
Raphaël Chèvre ◽  
Olivier Le Bihan ◽  
Fanny Beilvert ◽  
Benoit Chatin ◽  
Benoit Barteau ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Block Copolymers ◽  
Membrane Transport ◽  
Cellular Uptake ◽  
Amphiphilic Block Copolymers ◽  
Dna Molecules

Analysis of Thiol-sensitive Core-cross-linked Polymeric Micelles Carrying Nucleoside Pendant Groups using 'On-line' Methods: Effect of Hydrophobicity on Cross-linking and Degradation

2011 ◽  
Vol 64 (6) ◽  
pp. 766 ◽  
Author(s):  
Bianca M. Blunden ◽  
Donald S. Thomas ◽  
Martina H. Stenzel
Keyword(s):  
Block Copolymers ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Copolymer Composition ◽  
Reversible Addition ◽  
On Line ◽  
Styrene Content ◽  
Poly Ethylene

Amphiphilic block copolymers were prepared via reversible–addition fragmentation chain transfer (RAFT) polymerization and their synthesis, cross-linking, and degradation were studied using on-line monitoring. The focus of this work is the systematic alteration of the hydrophobic block using copolymers based on 5′-O-methacryloyluridine (MAU) and styrene at different compositions to determine the effect of the copolymer composition on the properties of the micelle. A poly(poly(ethylene glycol) methyl ether methacrylate) (PEGMA) macroRAFT agent was chain extended with a mixture of styrene and MAU. In both systems, an increasing fraction of styrene was found to reduce the rate of polymerization, but the functionality of the RAFT system was always maintained. The amphiphilic block copolymers were dialyzed against water to generate micelles with sizes between 17 and 25 nm according to dynamic light scattering (DLS). Increasing styrene content lead to smaller micelles (determined by DLS and transmission electron microscopy) and to lower critical micelle concentrations, which was measured using surface tensiometry. The micelles were further stabilized via core-cross-linking using bis(2-methacroyloxyethyl) disulfide as crosslinker. NMR analysis revealed a faster consumption of crosslinker with higher styrene content. These stable cross-linked micelles were investigated regarding their ability to degrade in the presence of dithiothreitol as a model reductant. Increasing the styrene content resulted in a faster degradation of the cross-linked micelles into unimers.

Reduction-responsive dithiomaleimide-based polymeric micelles for controlled anti-cancer drug delivery and bioimaging

2017 ◽  
Vol 8 (46) ◽  
pp. 7160-7168 ◽  
Author(s):  
Ting Bai ◽  
Junjie Du ◽  
Jianxin Chen ◽  
Xiao Duan ◽  
Qiang Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Tumor Cells ◽  
Disulfide Bonds ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Model Drug ◽  
Cancer Drug Delivery

The biocompatible amphiphilic block copolymers and the CPT model drug were self-assembled into micelles with bright fluorescence and taken up by tumor cells. Then, the disulfide bonds in the micelles were cleaved to release CPT at a high GSH concentration.

A Simple Protocol to Stabilize Gold Nanoparticles using Amphiphilic Block Copolymers: Stability Studies and Viable Cellular Uptake

2009 ◽  
Vol 15 (42) ◽  
pp. 11151-11159 ◽  
Author(s):  
Kamil Rahme ◽  
Patricia Vicendo ◽  
Cédric Ayela ◽  
Cédric Gaillard ◽  
Bruno Payré ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Block Copolymers ◽  
Cellular Uptake ◽  
Amphiphilic Block Copolymers ◽  
Stability Studies ◽  
Simple Protocol

Polymeric Micelles Using Pseudo-Amphiphilic Block Copolymers

2012 ◽  
Vol 313-314 (1) ◽  
pp. 51-58
Author(s):  
Massimo Benaglia ◽  
Enzo Spisni ◽  
Angelo Alberti ◽  
Loris Giorgini ◽  
Francesco Magnoni ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers

scholarly journals Amphiphilic Block Copolymers Enhance Cellular Uptake and Nuclear Entry of Polyplex-Delivered DNA

2008 ◽  
Vol 19 (10) ◽  
pp. 1987-1994 ◽  
Author(s):  
Zhihui Yang ◽  
Gaurav Sahay ◽  
Srikanth Sriadibhatla ◽  
Alexander V. Kabanov
Keyword(s):  
Block Copolymers ◽  
Cellular Uptake ◽  
Amphiphilic Block Copolymers ◽  
Nuclear Entry

scholarly journals Nanocarriers based on block copolymers of l-proline and lactide: the effect of core crosslinking versus its pH-sensitivity on their cellular uptake

2021 ◽  
pp. 110572
Author(s):  
Marek Brzeziński ◽  
Bartłomiej Kost Investigatio ◽  
Weronika Gonciarz ◽  
Agnieszka Krupa ◽  
Marta Socka ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Cellular Uptake ◽  
Ph Sensitivity
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