Effect of block compositions of amphiphilic block copolymers on the physicochemical properties of polymeric micelles

Polymer ◽  
2011 ◽  
Vol 52 (17) ◽  
pp. 3783-3790 ◽  
Author(s):  
Wei Li ◽  
Masamichi Nakayama ◽  
Jun Akimoto ◽  
Teruo Okano
Keyword(s):  
Block Copolymers ◽  
Physicochemical Properties ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers

Analysis of Thiol-sensitive Core-cross-linked Polymeric Micelles Carrying Nucleoside Pendant Groups using 'On-line' Methods: Effect of Hydrophobicity on Cross-linking and Degradation

2011 ◽  
Vol 64 (6) ◽  
pp. 766 ◽  
Author(s):  
Bianca M. Blunden ◽  
Donald S. Thomas ◽  
Martina H. Stenzel
Keyword(s):  
Block Copolymers ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Copolymer Composition ◽  
Reversible Addition ◽  
On Line ◽  
Styrene Content ◽  
Poly Ethylene

Amphiphilic block copolymers were prepared via reversible–addition fragmentation chain transfer (RAFT) polymerization and their synthesis, cross-linking, and degradation were studied using on-line monitoring. The focus of this work is the systematic alteration of the hydrophobic block using copolymers based on 5′-O-methacryloyluridine (MAU) and styrene at different compositions to determine the effect of the copolymer composition on the properties of the micelle. A poly(poly(ethylene glycol) methyl ether methacrylate) (PEGMA) macroRAFT agent was chain extended with a mixture of styrene and MAU. In both systems, an increasing fraction of styrene was found to reduce the rate of polymerization, but the functionality of the RAFT system was always maintained. The amphiphilic block copolymers were dialyzed against water to generate micelles with sizes between 17 and 25 nm according to dynamic light scattering (DLS). Increasing styrene content lead to smaller micelles (determined by DLS and transmission electron microscopy) and to lower critical micelle concentrations, which was measured using surface tensiometry. The micelles were further stabilized via core-cross-linking using bis(2-methacroyloxyethyl) disulfide as crosslinker. NMR analysis revealed a faster consumption of crosslinker with higher styrene content. These stable cross-linked micelles were investigated regarding their ability to degrade in the presence of dithiothreitol as a model reductant. Increasing the styrene content resulted in a faster degradation of the cross-linked micelles into unimers.

Polymeric micelles using pseudo-amphiphilic block copolymers and their cellular uptake

2011 ◽  
Vol 21 (8) ◽  
pp. 2555 ◽  
Author(s):  
Massimo Benaglia ◽  
Angelo Alberti ◽  
Enzo Spisni ◽  
Alessio Papi ◽  
Emanuele Treossi ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Cellular Uptake ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers

Reduction-responsive dithiomaleimide-based polymeric micelles for controlled anti-cancer drug delivery and bioimaging

2017 ◽  
Vol 8 (46) ◽  
pp. 7160-7168 ◽  
Author(s):  
Ting Bai ◽  
Junjie Du ◽  
Jianxin Chen ◽  
Xiao Duan ◽  
Qiang Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Tumor Cells ◽  
Disulfide Bonds ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Model Drug ◽  
Cancer Drug Delivery

The biocompatible amphiphilic block copolymers and the CPT model drug were self-assembled into micelles with bright fluorescence and taken up by tumor cells. Then, the disulfide bonds in the micelles were cleaved to release CPT at a high GSH concentration.

Polymeric Micelles Using Pseudo-Amphiphilic Block Copolymers

2012 ◽  
Vol 313-314 (1) ◽  
pp. 51-58
Author(s):  
Massimo Benaglia ◽  
Enzo Spisni ◽  
Angelo Alberti ◽  
Loris Giorgini ◽  
Francesco Magnoni ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Characterization of New Amphiphilic Block Copolymers of N-Vinylpyrrolidone and Vinyl Acetate, 2 - Chromatographic Separation and Analysis by MALDI-TOF and FT-IR Coupling

2010 ◽  
Vol 211 (15) ◽  
pp. 1678-1688 ◽  
Author(s):  
Nick Fandrich ◽  
Jana Falkenhagen ◽  
Steffen M. Weidner ◽  
Bastiaan Staal ◽  
Andreas F. Thünemann ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Vinyl Acetate ◽  
Chromatographic Separation ◽  
Amphiphilic Block Copolymers ◽  
Maldi Tof ◽  
Ft Ir

Synthesis and Aggregation Behavior of Four-Arm Star Amphiphilic Block Copolymers in Water

Langmuir ◽  
2006 ◽  
Vol 22 (23) ◽  
pp. 9746-9752 ◽  
Author(s):  
Michael R. Whittaker ◽  
Michael J. Monteiro
Keyword(s):  
Block Copolymers ◽  
Aggregation Behavior ◽  
Amphiphilic Block Copolymers
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