A novel molecular conjugate for the simultaneous DNA oxidation and targeted delivery of nitric oxide triggered by light

2009 ◽  
Vol 8 (11) ◽  
pp. 1534 ◽  
Author(s):  
Guido Bellia ◽  
Elisa Vittorino ◽  
Salvatore Sortino
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery ◽  
Dna Oxidation ◽  
Molecular Conjugate

scholarly journals Genotoxic and oxidative effect of duloxetine on mouse brain and liver tissues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Isela Álvarez-González ◽  
Scarlett Camacho-Cantera ◽  
Patricia Gómez-González ◽  
Michael J. Rendón Barrón ◽  
José A. Morales-González ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Mouse Brain ◽  
Control Level ◽  
Dna Oxidation ◽  
Methyl Methanesulfonate ◽  
Control Group ◽  
Oxidative Potential ◽  
The Brain ◽  
Oxidative Effect

AbstractWe evaluated the duloxetine DNA damaging capacity utilizing the comet assay applied to mouse brain and liver cells, as well as its DNA, lipid, protein, and nitric oxide oxidative potential in the same cells. A kinetic time/dose strategy showed the effect of 2, 20, and 200 mg/kg of the drug administered intraperitoneally once in comparison with a control and a methyl methanesulfonate group. Each parameter was evaluated at 3, 9, 15, and 21 h postadministration in five mice per group, except for the DNA oxidation that was examined only at 9 h postadministration. Results showed a significant DNA damage mainly at 9 h postexposure in both organs. In the brain, with 20 and 200 mg/kg we found 50 and 80% increase over the control group (p ≤ 0.05), in the liver, the increase of 2, 20, and 200 mg/kg of duloxetine was 50, 80, and 135% in comparison with the control level (p ≤ 0.05). DNA, lipid, protein and nitric oxide oxidation increase was also observed in both organs. Our data established the DNA damaging capacity of duloxetine even with a dose from the therapeutic range (2 mg/kg), and suggest that this effect can be related with its oxidative potential.

A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

2016 ◽  
Vol 4 (27) ◽  
pp. 4667-4674 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Min Guo ◽  
Lu An ◽  
Shi-Ping Yang ◽  
Qian-Ling Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

NIR light induced spatiotemporal delivery of NO to lysosome accompanied by hyperthermia was realized.

Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair

2018 ◽  
Vol 15 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Jingli Hou ◽  
Yiwa Pan ◽  
Dashuai Zhu ◽  
Yueyuan Fan ◽  
Guowei Feng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery

Targeted delivery of nitric oxide

Nature ◽  
2001 ◽  
Vol 409 (6820) ◽  
pp. 577-578 ◽  
Author(s):  
Steven S. Gross
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery

Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

2016 ◽  
Vol 52 (1) ◽  
pp. 148-151 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Qiao Deng ◽  
Lu An ◽  
Min Guo ◽  
Shi-Ping Yang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy ◽  
Tumor Cell ◽  
Cancer Cell ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform (Lyso-Ru-NO@FA@C-TiO2) (1) was developed.

Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

2017 ◽  
Vol 53 (22) ◽  
pp. 3253-3256 ◽  
Author(s):  
Min Guo ◽  
Hui-Jing Xiang ◽  
Yi Wang ◽  
Qian-Ling Zhang ◽  
Lu An ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Quantum Dots ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Graphene Quantum Dots ◽  
Antitumor Efficacy ◽  
Functionalized Graphene ◽  
Ruthenium Nitrosyl ◽  
Nir Light

Targeted delivery of NO accompanied by photothermal therapy shows efficient in vivo antitumor efficacy.

scholarly journals A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells

RSC Advances ◽  
2014 ◽  
Vol 4 (84) ◽  
pp. 44827-44836 ◽  
Author(s):  
Aurore Fraix ◽  
Stefano Guglielmo ◽  
Venera Cardile ◽  
Adriana C. E. Graziano ◽  
Ruxandra Gref ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Red Fluorescence ◽  
Melanoma Cancer ◽  
Molecular Conjugate

A bichromophoric molecular conjugate combines red fluorescence with the simultaneous photogeneration of singlet oxygen and nitric oxide, inducing amplified photomortality on melanoma cancer cells.

scholarly journals Synthesis of N-Pyridin-2-ylmethyl and N-Quinolin-2-ylmethyl ­Substituted Ethane-1,2-diamines

SynOpen ◽  
2017 ◽  
Vol 01 (01) ◽  
pp. 0147-0155 ◽  
Author(s):  
Yi-Qiu Yang ◽  
Long-Zhi Ke ◽  
Gui-Fei Wang ◽  
Shu-Yong Song ◽  
Ming-Ning Qiu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metal Ions ◽  
Targeted Delivery ◽  
Metal Ion ◽  
Synthesis And Characterization ◽  
Long Wavelength ◽  
Initial Work ◽  
Wavelength Light

Two N-(2-(bis(pyridin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides and two N-(2-(bis(quinolin-2-ylmethyl)amino)ethyl)quinoline-2-carboxamides have been synthesized. These structures contain five nitrogen atoms that can form coordinate bonds with metal ions such as Mn(II) and Fe(II). An additional coordinating bond can be formed between the metal ion and a neutral molecule of nitric oxide (NO). The resultant complexes are potentially useful agents for targeted delivery of NO to in vivo biological sites such as tumors, where the NO is released upon irradiation with long-wavelength light. Initial work involving the synthesis and characterization of these analogues is reported here.

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