scholarly journals Random walk of single gold nanoparticles in zebrafish embryos leading to stochastic toxic effects on embryonic developments

Nanoscale ◽  
2009 ◽  
Vol 1 (1) ◽  
pp. 138 ◽  
Author(s):  
Lauren M. Browning ◽  
Kerry J. Lee ◽  
Tao Huang ◽  
Prakash D. Nallathamby ◽  
Jill E. Lowman ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Random Walk ◽  
Toxic Effects ◽  
Zebrafish Embryos

scholarly journals The Role of Polymeric Coatings for a Safe-by-Design Development of Biomedical Gold Nanoparticles Assessed in Zebrafish Embryo

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1004
Author(s):  
Pamela Floris ◽  
Stefania Garbujo ◽  
Gabriele Rolla ◽  
Marco Giustra ◽  
Lucia Salvioni ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Significant Inhibition ◽  
Zebrafish Embryos ◽  
Design Development ◽  
Embryo Viability ◽  
Fish Embryo ◽  
Toxic Response ◽  
Consequent Reduction ◽  
Vertebrate Model ◽  
Safe By Design

In the biomedical field, gold nanoparticles (GNPs) have attracted the attention of the scientific community thanks to their high potential in both diagnostic and therapeutic applications. The extensive use of GNPs led researchers to investigate their toxicity, identifying stability, size, shape, and surface charge as key properties determining their impact on biological systems, with possible strategies defined to reduce it according to a Safe-by-Design (SbD) approach. The purpose of the present work was to analyze the toxicity of GNPs of various sizes and with different coating polymers on the developing vertebrate model, zebrafish. In particular, increasing concentrations (from 0.001 to 1 nM) of 6 or 15 nm poly-(isobutylene-alt-maleic anhydride)-graft-dodecyl polymer (PMA)- or polyethylene glycol (PEG)-coated GNPs were tested on zebrafish embryos using the fish embryo test (FET). While GNP@PMA did not exert significant toxicity on zebrafish embryos, GNP@PEG induced a significant inhibition of embryo viability, a delay of hatching (with the smaller size NPs), and a higher incidence of malformations, in terms of tail morphology and eye development. Transmission electron microscope analysis evidenced that the more negatively charged GNP@PMA was sequestered by the positive charges of chorion proteins, with a consequent reduction in the amount of NPs able to reach the developing embryo and exert toxicological activity. The mild toxic response observed on embryos directly exposed to GNP@PMA suggest that these NPs are promising in terms of SbD development of gold-based biomedical nanodevices. On the other hand, the almost neutral GNP@PEG, which did not interact with the chorion surface and was free to cross chorion pores, significantly impacted the developing zebrafish. The present study raises concerns about the safety of PEGylated gold nanoparticles and contributes to the debated issue of the free use of this nanotool in medicine and nano-biotechnologies.

Emerging contaminant occurrence and toxic effects on zebrafish embryos to assess the adverse effects caused by mixtures of substances in the environment

2021 ◽  
Author(s):  
Gisela de Assis Martini ◽  
Cassiana Carolina Montagner ◽  
William Viveiros ◽  
Gilson Alves Quinaglia ◽  
Daniela Dayrell França ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Toxic Effects ◽  
Zebrafish Embryos ◽  
Emerging Contaminant

Particle-specific toxic effects of differently shaped zinc oxide nanoparticles to zebrafish embryos (Danio rerio )

2014 ◽  
Vol 33 (12) ◽  
pp. 2859-2868 ◽  
Author(s):  
Jing Hua ◽  
Martina G. Vijver ◽  
Michael K. Richardson ◽  
Farooq Ahmad ◽  
Willie J.G.M. Peijnenburg
Keyword(s):  
Zinc Oxide ◽  
Danio Rerio ◽  
Zinc Oxide Nanoparticles ◽  
Toxic Effects ◽  
Oxide Nanoparticles ◽  
Zebrafish Embryos

Exposure to the azo dye Direct blue 15 produces toxic effects on microalgae, cladocerans, and zebrafish embryos

Ecotoxicology ◽  
2019 ◽  
Vol 28 (8) ◽  
pp. 890-902 ◽  
Author(s):  
Miriam Hernández-Zamora ◽  
Fernando Martínez-Jerónimo
Keyword(s):  
Azo Dye ◽  
Toxic Effects ◽  
Zebrafish Embryos ◽  
Direct Blue ◽  
Direct Blue 15

scholarly journals Comparison of the in vitro and in vivo toxic effects of thymoquinone using oral cancer HSC-3 and HSC-4 cell lines, oral fibroblasts, HACAT cell line, and Zebrafish embryos

2019 ◽  
Vol 16 ◽  
pp. 2108-2114
Author(s):  
Wastuti Hidayati Suriyah ◽  
Abdul Razak Kasmuri ◽  
Fiona How Ni Foong ◽  
Dhona Afriza ◽  
Solachuddin Jauhari Arief Ichwan
Keyword(s):  
Oral Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Hacat Cell ◽  
Toxic Effects ◽  
Zebrafish Embryos ◽  
Hacat Cell Line

Toxic effects of gold nanoparticles and gold ions in human umbilical cord derived mesenchymal stem cells

2015 ◽  
Vol 208 ◽  
pp. S101
Author(s):  
Gamze Tan ◽  
Necdet Sağlam ◽  
Melek Yaman ◽  
Nihan Örüklü ◽  
Emin Ümit Bağrıaçık
Keyword(s):  
Stem Cells ◽  
Gold Nanoparticles ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Toxic Effects ◽  
Human Umbilical Cord

Toxic effects of micro-plastics on zebrafish embryos

Toxicon ◽  
2019 ◽  
Vol 158 ◽  
pp. S70-S71
Author(s):  
Tian-le Tang ◽  
Yu-yang Zhang ◽  
Ling He
Keyword(s):  
Toxic Effects ◽  
Zebrafish Embryos

Phytosynthesized gold nanoparticles from C. roxburghii DC. leaf and their toxic effects on normal and cancer cell lines

2016 ◽  
Vol 165 ◽  
pp. 163-173 ◽  
Author(s):  
Pannerselvam Balashanmugam ◽  
Prabhu Durai ◽  
Manickam Dakshinamoorthi Balakumaran ◽  
Pudupalayam Thangavelu Kalaichelvan
Keyword(s):  
Gold Nanoparticles ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Toxic Effects
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