Gas phase folding of an (Ala)4 neutral peptide chain: spectroscopic evidence for the formation of a β-hairpin H-bonding pattern

2009 ◽  
Vol 11 (48) ◽  
pp. 11385 ◽  
Author(s):  
Eric Gloaguen ◽  
Rodolphe Pollet ◽  
François Piuzzi ◽  
Benjamin Tardivel ◽  
Michel Mons
Keyword(s):  
Gas Phase ◽  
Peptide Chain ◽  
Spectroscopic Evidence ◽  
Neutral Peptide

scholarly journals Spectroscopic Evidence for Gas-Phase Formation of Successive β-Turns in a Three-Residue Peptide Chain

2005 ◽  
Vol 127 (5) ◽  
pp. 1388-1389 ◽  
Author(s):  
Wutharath Chin ◽  
Isabelle Compagnon ◽  
Jean-Pierre Dognon ◽  
Clélia Canuel ◽  
François Piuzzi ◽  
...  
Keyword(s):  
Gas Phase ◽  
Phase Formation ◽  
Peptide Chain ◽  
Spectroscopic Evidence

Spectroscopic evidence for a gas-phase librating G-quartet–Na+ complex

2014 ◽  
Vol 50 (94) ◽  
pp. 14767-14770 ◽  
Author(s):  
C. Fraschetti ◽  
M. Montagna ◽  
L. Guarcini ◽  
L. Guidoni ◽  
A. Filippi
Keyword(s):  
Gas Phase ◽  
Room Temperature ◽  
Spectroscopic Evidence

The Na+–G4 adduct exists as a mixture of two metastable populations, rapidly interconverting at room temperature.

Spectroscopic evidence of α-methylbenzyl radical in the gas phase

2008 ◽  
Vol 465 (4-6) ◽  
pp. 193-196 ◽  
Author(s):  
Gi Woo Lee ◽  
Hyeon Geun Ahn ◽  
Tae Kyu Kim ◽  
Sang Kuk Lee
Keyword(s):  
Gas Phase ◽  
Spectroscopic Evidence

Formation of Neutral Peptide Aggregates Studied by Mass Selective IR Action Spectroscopy

2019 ◽  
Author(s):  
Sjors Bakels ◽  
Sebastiaan Porskamp ◽  
Anouk Rijs
Keyword(s):  
Gas Phase ◽  
Self Assembly ◽  
Molecular Beam ◽  
Structural Changes ◽  
Uv Spectroscopy ◽  
Laser Desorption ◽  
Charged Species ◽  
Neutral Peptide ◽  
Proteins And Peptides

The spontaneous aggregation of proteins and peptides is widely studied due to its relation to neurodegenerative diseases. To understand the underlying principles of peptide aggregation, elucidation of structure and structural changes upon their formation is key. This level of detail can be obtained by studying the peptide self-assembly in the gas phase. Structural characterization of aggregates is mainly done on charged species, as adding charges is an intrinsic part of the technique to bring molecules into the gas phase. Studying neutral peptide aggregates will complement the existing picture. These studies are restricted to dimers due to experimental limitations. Here, we present advances in laser desorption molecular beam spectroscopy to form neutral peptide aggregates in the gas phase consisting of up to fourteen monomeric peptides. The combination with IR-UV spectroscopy allowed us to select each aggregate by size and subsequently characterize its structure.

Formation of Neutral Peptide Aggregates Studied by Mass Selective IR Action Spectroscopy

2019 ◽  
Author(s):  
Sjors Bakels ◽  
Sebastiaan Porskamp ◽  
Anouk Rijs
Keyword(s):  
Gas Phase ◽  
Self Assembly ◽  
Molecular Beam ◽  
Structural Changes ◽  
Uv Spectroscopy ◽  
Laser Desorption ◽  
Charged Species ◽  
Neutral Peptide ◽  
Proteins And Peptides

The spontaneous aggregation of proteins and peptides is widely studied due to its relation to neurodegenerative diseases. To understand the underlying principles of peptide aggregation, elucidation of structure and structural changes upon their formation is key. This level of detail can be obtained by studying the peptide self-assembly in the gas phase. Structural characterization of aggregates is mainly done on charged species, as adding charges is an intrinsic part of the technique to bring molecules into the gas phase. Studying neutral peptide aggregates will complement the existing picture. These studies are restricted to dimers due to experimental limitations. Here, we present advances in laser desorption molecular beam spectroscopy to form neutral peptide aggregates in the gas phase consisting of up to fourteen monomeric peptides. The combination with IR-UV spectroscopy allowed us to select each aggregate by size and subsequently characterize its structure.

Gas-Phase Folding of a Prototypical Protonated Pentapeptide: Spectroscopic Evidence for Formation of a Charge-Stabilized β-Hairpin

2016 ◽  
Vol 138 (8) ◽  
pp. 2849-2857 ◽  
Author(s):  
Nicole L. Burke ◽  
Andrew F. DeBlase ◽  
James G. Redwine ◽  
John R. Hopkins ◽  
Scott A. McLuckey ◽  
...  
Keyword(s):  
Gas Phase ◽  
Spectroscopic Evidence ◽  
A Charge

Gas-Phase Folding of a Two-Residue Model Peptide Chain: On the Importance of an Interplay between Experiment and Theory

2010 ◽  
Vol 132 (34) ◽  
pp. 11860-11863 ◽  
Author(s):  
E. Gloaguen ◽  
B. de Courcy ◽  
J.-P. Piquemal ◽  
J. Pilmé ◽  
O. Parisel ◽  
...  
Keyword(s):  
Gas Phase ◽  
Peptide Chain ◽  
Model Peptide

Computational and ultraviolet photoelectron spectroscopic evidence that (Z)-2-methyl-1,3-pentadiene prefers twisted s-cis conformers in the gas phase

1992 ◽  
Vol 70 (7) ◽  
pp. 1971-1977 ◽  
Author(s):  
Nick Henry Werstiuk ◽  
George Timmins ◽  
Jiangong Ma ◽  
Timothy A. Wildman
Keyword(s):  
Potential Energy ◽  
Gas Phase ◽  
Computational Methods ◽  
Potential Energy Surfaces ◽  
Spectroscopic Evidence ◽  
Orbital Energies ◽  
Trans Conformer ◽  
Energy Surfaces ◽  
Good Agreement

A redetermination of the ultraviolet photoelectron (pe) spectrum of (Z)-2-methyl-1,3-pentadiene has led to a correction of the published spectrum. By studying (Z)-2-methyl-1,3,-pentadiene (1a) and (E)-2-methyl-1,3-pentadiene (1b) with MMX, MNDO, AM1, and abinitio MO computational methods and pe spectroscopy, we have shown that a combination of these methods provides useful insights on the conformational behaviour of methyl-substituted 1,3-dienes in the gas phase. Synthetic pe spectra, derived from the computed potential energy surfaces and angle-dependent orbital energies, are in good agreement with experiment. Thus, the E isomer prefers the s-trans conformer but the Z isomer prefers twisted s-cis conformations in the gas phase.

Spectroscopic Evidence for Binary O2 Clusters in the Gas Phase

1967 ◽  
Vol 47 (1) ◽  
pp. 331-332 ◽  
Author(s):  
Roger P. Blickensderfer ◽  
George E. Ewing
Keyword(s):  
Gas Phase ◽  
Spectroscopic Evidence
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