Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

2009 ◽  
pp. 10871 ◽  
Author(s):  
Yong Leng Kelvin Tan ◽  
Pascal Pigeon ◽  
Elizabeth A. Hillard ◽  
Siden Top ◽  
Marie-Aude Plamont ◽  
...  
Keyword(s):  
Ferrocene Derivatives ◽  
Cytotoxicity Studies ◽  
Oxidation Chemistry ◽  
Derivatives Of

scholarly journals The protozoan toxin climacostol and its derivatives: Cytotoxicity studies on 10 species of free-living ciliates

Biologia ◽  
2010 ◽  
Vol 65 (4) ◽  
Author(s):  
Federico Buonanno ◽  
Claudio Ortenzi
Keyword(s):  
Common Species ◽  
Aliphatic Chain ◽  
Ciliated Protozoan ◽  
Anticancer Activities ◽  
Free Living ◽  
Parent Molecule ◽  
Cytotoxicity Studies ◽  
Resorcinolic Lipids ◽  
Derivatives Of ◽  
Freshwater Ciliates

AbstractClimacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum virens and belongs to resorcinolic lipids, a group of compounds that show antimicrobial, antiparasitic, and anticancer activities. We investigated the cytotoxic activity of the chemically synthesized toxin and its alkyl and alkynyl derivatives on C. virens and nine other common species of free-living freshwater ciliates. Our results show that the cytotoxic potency of climacostol can be modulated by the substitution of the double bond present in the aliphatic chain of the toxin with a single or a triple one that was previously obtained during the synthesis of the unsaturated and saturated derivatives of the parent molecule. We demonstrated that the cytotoxicity level of the molecules considered in this study appears to be inversely correlated to the unsaturation level of their aliphatic chains, and that the potency of their action is also related to the target organism.

Synthesis and Cytotoxicity Studies of Fluorinated Derivatives of Vanadocene Y

2009 ◽  
Vol 2009 (19) ◽  
pp. 2804-2810 ◽  
Author(s):  
Brendan Gleeson ◽  
James Claffey ◽  
Anthony Deally ◽  
Megan Hogan ◽  
Luis Miguel Menéndez Méndez ◽  
...  
Keyword(s):  
Cytotoxicity Studies ◽  
Fluorinated Derivatives ◽  
Derivatives Of

ChemInform Abstract: One-Pot Synthesis and Cytotoxicity Studies of New Mannich Base Derivatives of Polyether Antibiotic-Lasalocid Acid.

ChemInform ◽  
2014 ◽  
Vol 45 (4) ◽  
pp. no-no
Author(s):  
Adam Huczynski ◽  
Jacek Rutkowski ◽  
Izabela Borowicz ◽  
Joanna Wietrzyk ◽  
Ewa Maj ◽  
...  
Keyword(s):  
Mannich Base ◽  
One Pot ◽  
One Pot Synthesis ◽  
Cytotoxicity Studies ◽  
Derivatives Of

Synthesis and redox chemistry of 1,1′-bis(diphenylphosphino)ferrocene derivatives of R2C2Co2(CO)6 (R  MeO2C, CF3)

1997 ◽  
Vol 527 (1-2) ◽  
pp. 179-190 ◽  
Author(s):  
C.John McAdam ◽  
Noel W. Duffy ◽  
Brian H. Robinson ◽  
Jim Simpson
Keyword(s):  
Redox Chemistry ◽  
Ferrocene Derivatives ◽  
Derivatives Of

Electron-transfer biosensors

1987 ◽  
Vol 316 (1176) ◽  
pp. 95-106 ◽  
Keyword(s):  
Electron Transfer ◽  
Glucose Oxidase ◽  
Organometallic Compound ◽  
Electrode Reaction ◽  
Transfer Reactions ◽  
Ferrocene Derivatives ◽  
Electron Transfer Reactions ◽  
Redox Proteins ◽  
Copper Protein ◽  
Derivatives Of

The electrochemistry of redox proteins is now well established. Conditions exist which allow electron-transfer reactions of all simple proteins to proceed rapidly and reversibly at electrodes. Coupling of the electrode reaction to enzymes, for which the redox proteins act as cofactors, allows exploitation of this good electrochemistry. This is well illustrated by the enzyme-catalysed electrochemical oxidation of p -cresol to p -hydroxybenzaldehyde, which has been shown to proceed along with coupling to the electrode via the copper protein, azurin, or the organometallic compound ferroceneboronic acid. Ferrocene derivatives, in general, show a degree of versatility, coupling the electron-transfer reactions of many enzymes. Thus derivatives of the ferricinium ion act as excellent electron-transfer reagents from the enzyme glucose oxidase. The system is capable of detecting glucose in blood. Similar procedures, in conjunction with the appropriate enzyme, have yielded assays for, among others, H 2 O 2 and cholesterol.

Fluorinated Derivatives of Titanocene Y: Synthesis and Cytotoxicity Studies

2008 ◽  
Vol 2008 (26) ◽  
pp. 4074-4082 ◽  
Author(s):  
James Claffey ◽  
Brendan Gleeson ◽  
Megan Hogan ◽  
Helge Müller-Bunz ◽  
Denise Wallis ◽  
...  
Keyword(s):  
Cytotoxicity Studies ◽  
Fluorinated Derivatives ◽  
Derivatives Of

scholarly journals Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol

2016 ◽  
Vol 31 (6) ◽  
pp. 1375-1380 ◽  
Author(s):  
Halise Inci Gul ◽  
Cem Yamali ◽  
Asiye Tugce Yasa ◽  
Elif Unluer ◽  
Hiroshi Sakagami ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Mannich Base ◽  
Cytotoxicity Studies ◽  
Carbonic Anhydrase Inhibition ◽  
Derivatives Of

Bis-ferrocene derivatives of bridged calix[4]arenes: syntheis, X-ray crystal structure and electrochemical properties

1991 ◽  
Vol 421 (2-3) ◽  
pp. 265-273 ◽  
Author(s):  
Paul D. Beer ◽  
Anthony D. Keefe ◽  
Volker Böhmer ◽  
Helmut Goldmann ◽  
Walter Vogt ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Electrochemical Properties ◽  
Ferrocene Derivatives ◽  
X Ray ◽  
Derivatives Of
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