Synthesis and Cytotoxicity Studies of Fluorinated Derivatives of Vanadocene Y

2009 ◽  
Vol 2009 (19) ◽  
pp. 2804-2810 ◽  
Author(s):  
Brendan Gleeson ◽  
James Claffey ◽  
Anthony Deally ◽  
Megan Hogan ◽  
Luis Miguel Menéndez Méndez ◽  
...  
Keyword(s):  
Cytotoxicity Studies ◽  
Fluorinated Derivatives ◽  
Derivatives Of

Fluorinated Derivatives of Titanocene Y: Synthesis and Cytotoxicity Studies

2008 ◽  
Vol 2008 (26) ◽  
pp. 4074-4082 ◽  
Author(s):  
James Claffey ◽  
Brendan Gleeson ◽  
Megan Hogan ◽  
Helge Müller-Bunz ◽  
Denise Wallis ◽  
...  
Keyword(s):  
Cytotoxicity Studies ◽  
Fluorinated Derivatives ◽  
Derivatives Of

Ultrafast photoinduced charge transfer in fluorinated derivatives of DMABN

2004 ◽  
pp. 323-326
Author(s):  
S. Murali ◽  
P. Changenet-Barret ◽  
C. Ley ◽  
P. Plaza ◽  
W. Rettig ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Photoinduced Charge Transfer ◽  
Fluorinated Derivatives ◽  
Photoinduced Charge ◽  
Derivatives Of

Fluorinated Derivatives of Ethane

1947 ◽  
Vol 39 (3) ◽  
pp. 409-412 ◽  
Author(s):  
E. McBee ◽  
H. Hass ◽  
W. Bittenbender ◽  
W. Weesner ◽  
W. Toland, Jr. ◽  
...  
Keyword(s):  
Fluorinated Derivatives ◽  
Derivatives Of

Fluorinated derivatives of p-isopropyltoluene

1947 ◽  
Vol 39 (3) ◽  
pp. 399-401 ◽  
Author(s):  
E. McBee ◽  
O. Pierce
Keyword(s):  
Fluorinated Derivatives ◽  
Derivatives Of

scholarly journals The protozoan toxin climacostol and its derivatives: Cytotoxicity studies on 10 species of free-living ciliates

Biologia ◽  
2010 ◽  
Vol 65 (4) ◽  
Author(s):  
Federico Buonanno ◽  
Claudio Ortenzi
Keyword(s):  
Common Species ◽  
Aliphatic Chain ◽  
Ciliated Protozoan ◽  
Anticancer Activities ◽  
Free Living ◽  
Parent Molecule ◽  
Cytotoxicity Studies ◽  
Resorcinolic Lipids ◽  
Derivatives Of ◽  
Freshwater Ciliates

AbstractClimacostol (5-(Z)-non-2-enyl-benzene-1,3-diol) is a natural toxin isolated from the freshwater ciliated protozoan Climacostomum virens and belongs to resorcinolic lipids, a group of compounds that show antimicrobial, antiparasitic, and anticancer activities. We investigated the cytotoxic activity of the chemically synthesized toxin and its alkyl and alkynyl derivatives on C. virens and nine other common species of free-living freshwater ciliates. Our results show that the cytotoxic potency of climacostol can be modulated by the substitution of the double bond present in the aliphatic chain of the toxin with a single or a triple one that was previously obtained during the synthesis of the unsaturated and saturated derivatives of the parent molecule. We demonstrated that the cytotoxicity level of the molecules considered in this study appears to be inversely correlated to the unsaturation level of their aliphatic chains, and that the potency of their action is also related to the target organism.

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