Controllable stereoselective synthesis of trisubstituted alkenes by a catalytic three-component reaction of terminal alkynes, benzylic alcohols, and simple arenes

2009 ◽  
Vol 7 (16) ◽  
pp. 3219 ◽  
Author(s):  
Hai-Hua Li ◽  
Yin-Huan Jin ◽  
Jie-Qi Wang ◽  
Shi-Kai Tian
Keyword(s):  
Stereoselective Synthesis ◽  
Terminal Alkynes ◽  
Benzylic Alcohols ◽  
Three Component Reaction ◽  
Trisubstituted Alkenes

An efficient one-pot stereoselective synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans

2021 ◽  
Vol 08 ◽  
Author(s):  
Chithaluri Sudhakar ◽  
Pochamoni Ramudu
Keyword(s):  
Room Temperature ◽  
Stereoselective Synthesis ◽  
One Pot ◽  
Three Component Reaction

: An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one pot three-component reaction of aldehydes, trimethyl allylsilane and NH4SCN in the presence of BF3.Et2O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).

A regio- and stereoselective synthesis of trisubstituted alkenes via gold(i)-catalyzed hydrophosphoryloxylation of haloalkynes

2011 ◽  
Vol 47 (27) ◽  
pp. 7851 ◽  
Author(s):  
Bathoju Chandra Chary ◽  
Sunggak Kim ◽  
Doosup Shin ◽  
Phil Ho Lee
Keyword(s):  
Stereoselective Synthesis ◽  
Trisubstituted Alkenes

scholarly journals Alkoxide-catalyzed addition of alkyl carbonates across alkynes – stereoselective synthesis of (E)-β-alkoxyacrylates

2017 ◽  
Vol 19 (3) ◽  
pp. 643-646
Author(s):  
Timo Wendling ◽  
Eugen Risto ◽  
Benjamin Erb ◽  
Lukas J. Gooßen
Keyword(s):  
Stereoselective Synthesis ◽  
Terminal Alkynes ◽  
Potassium Methoxide ◽  
Stereoselective Addition

Terminal alkynes were converted to (E)-β-alkoxyacrylates via regio- and stereoselective addition of dialky carbonates catalyzed by potassium methoxide.

Consecutive Multicomponent Reactions: Synthesis of 3-Acyl-4-alkynyl-Substituted 1,3-Thiazolidines

Synthesis ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 1123-1132 ◽  
Author(s):  
Jürgen Martens ◽  
Torben Schlüter ◽  
Nils Frerichs ◽  
Marc Schmidtmann
Keyword(s):  
Functional Groups ◽  
Multicomponent Reactions ◽  
Terminal Alkynes ◽  
Synthetic Route ◽  
Acyl Chlorides ◽  
Mild Conditions ◽  
Three Component Reaction

This work describes the synthesis of compounds containing thiazolidine and propargylamidic motifs. Their preparation follows a synthetic route containing two multicomponent reactions. First, the Asinger four-component reaction is used to prepare 3-thiazolines and 3-oxazolines. Secondly, these heterocyclic imines are converted into propargylamides by a copper-catalyzed three-component reaction using acyl chlorides and terminal alkynes. The synthetic route is characterized by mild conditions and many functional groups are tolerated. The formation of an unexpected α-alkynoxyamide is also presented.

One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF6 system

2021 ◽  
Author(s):  
Guguloth Veeranna ◽  
Ramesh Balaboina ◽  
Narasimha Swamy Thirukovela ◽  
Ravindhar Vadde
Keyword(s):  
Secondary Amines ◽  
Terminal Alkynes ◽  
One Pot ◽  
One Pot Synthesis ◽  
System P ◽  
Three Component Reaction ◽  
The One

The one-pot three-component reaction of several 2-ketoaldehdyes, secondary amines and terminal alkynes to access 3-aminofurans was proceeded well in [bmim][PF6] using a simple and cheap CuI catalyst. The resulted 3-aminofuran...

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