scholarly journals Water permeation through stratum corneum lipid bilayers from atomistic simulations

Soft Matter ◽  
2009 ◽  
Vol 5 (22) ◽  
pp. 4549 ◽  
Author(s):  
Chinmay Das ◽  
Peter D. Olmsted ◽  
Massimo G. Noro
Keyword(s):  
Stratum Corneum ◽  
Lipid Bilayers ◽  
Atomistic Simulations ◽  
Water Permeation ◽  
Stratum Corneum Lipid

scholarly journals Effect of Ceramide Tail Length on the Structure of Model Stratum Corneum Lipid Bilayers

2018 ◽  
Vol 114 (1) ◽  
pp. 113-125 ◽  
Author(s):  
Timothy C. Moore ◽  
Remco Hartkamp ◽  
Christopher R. Iacovella ◽  
Annette L. Bunge ◽  
Clare McCabe
Keyword(s):  
Stratum Corneum ◽  
Lipid Bilayers ◽  
Tail Length ◽  
Stratum Corneum Lipid

A Liposome Permeability Model for Stratum Corneum Lipid Bilayers Based on Commercial Lipids

2008 ◽  
Vol 97 (10) ◽  
pp. 4278-4293 ◽  
Author(s):  
Marjukka Suhonen ◽  
S.Kevin Li ◽  
William I. Higuchi ◽  
James N. Herron
Keyword(s):  
Stratum Corneum ◽  
Lipid Bilayers ◽  
Permeability Model ◽  
Stratum Corneum Lipid

scholarly journals The physics of stratum corneum lipid membranes

2016 ◽  
Vol 374 (2072) ◽  
pp. 20150126 ◽  
Author(s):  
Chinmay Das ◽  
Peter D. Olmsted
Keyword(s):  
Stratum Corneum ◽  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Plasma Membranes ◽  
Lipid Matrix ◽  
Large Variability ◽  
Head Groups ◽  
Stratum Corneum Lipid ◽  
Main Barrier ◽  
Lipid Assemblies

The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix show small hydrophilic groups and large variability in the length of the alkyl tails and in the numbers and positions of groups that are capable of forming hydrogen bonds. Molecular simulations provide a route for systematically probing the effects of each of these differences separately. In this article, we present the results from atomistic molecular dynamics of selected lipid bilayers and multi-layers to probe the effect of these polydispersities. We address the nature of the tail packing in the gel-like phase, the hydrogen bond network among head groups, the bending moduli expected for leaflets comprising SC lipids and the conformation of very long ceramide lipids in multi-bilayer lipid assemblies. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’.

scholarly journals Cholesterol Flip-Flop and Lack of Swelling in Stratum Corneum Lipid Bilayers

2015 ◽  
Vol 108 (2) ◽  
pp. 413a
Author(s):  
Peter Olmsted ◽  
Chinmay Das ◽  
Massimo Noro
Keyword(s):  
Stratum Corneum ◽  
Lipid Bilayers ◽  
Flip Flop ◽  
Stratum Corneum Lipid

Effect of microplasma treatment on stratum corneum lipid molecule

2020 ◽  
Vol 59 (SH) ◽  
pp. SHHF06
Author(s):  
J. Kristof ◽  
T. Aoshima ◽  
M. Blajan ◽  
K. Shimizu
Keyword(s):  
Stratum Corneum ◽  
Lipid Molecule ◽  
Stratum Corneum Lipid

Further investigations on the role of ascorbic acid in stratum corneum lipid models after UV exposure

2005 ◽  
Vol 57 (8) ◽  
pp. 963-972
Author(s):  
Hagen Trommer ◽  
Rolf Böttcher ◽  
Christoph Huschka ◽  
Wolfgang Wohlrab ◽  
Reinhard H. H. Neubert
Keyword(s):  
Ascorbic Acid ◽  
Stratum Corneum ◽  
Uv Exposure ◽  
Stratum Corneum Lipid

Role of Stratum Corneum Lipid Fluidity in Transdermal Drug Flux

1987 ◽  
Vol 76 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Guia M. Golden ◽  
James E. McKie ◽  
Russell O. Potts
Keyword(s):  
Stratum Corneum ◽  
Lipid Fluidity ◽  
Stratum Corneum Lipid ◽  
Drug Flux
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