Role of Stratum Corneum Lipid Fluidity in Transdermal Drug Flux

1987 ◽  
Vol 76 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Guia M. Golden ◽  
James E. McKie ◽  
Russell O. Potts
Keyword(s):  
Stratum Corneum ◽  
Lipid Fluidity ◽  
Stratum Corneum Lipid ◽  
Drug Flux

Further investigations on the role of ascorbic acid in stratum corneum lipid models after UV exposure

2005 ◽  
Vol 57 (8) ◽  
pp. 963-972
Author(s):  
Hagen Trommer ◽  
Rolf Böttcher ◽  
Christoph Huschka ◽  
Wolfgang Wohlrab ◽  
Reinhard H. H. Neubert
Keyword(s):  
Ascorbic Acid ◽  
Stratum Corneum ◽  
Uv Exposure ◽  
Stratum Corneum Lipid

scholarly journals Probing the Unique Role of Ultralong-Chain Omega-Acylceramide Cer[EOS] in a Stratum Corneum Lipid Model Matrix using 2H NMR

2021 ◽  
Vol 120 (3) ◽  
pp. 323a
Author(s):  
Ferdinand Fandrei ◽  
Oskar Engberg ◽  
Lukáš Opálka ◽  
Kateřina Vávrová ◽  
Daniel Huster
Keyword(s):  
Stratum Corneum ◽  
2H Nmr ◽  
Unique Role ◽  
Stratum Corneum Lipid ◽  
Model Matrix

Role of Ceramides 2 and 5 in the Structure of the Stratum Corneum Lipid Barrier

1999 ◽  
Vol 21 (5) ◽  
pp. 353-368 ◽  
Author(s):  
David J. Moore ◽  
Mark E. Rerek ◽  
Richard Mendelsohn
Keyword(s):  
Stratum Corneum ◽  
Stratum Corneum Lipid

The role of ceramides 1 and 2 in the stratum corneum lipid organisation

1996 ◽  
Vol 1300 (3) ◽  
pp. 177-186 ◽  
Author(s):  
Joke A. Bouwstra ◽  
K. Cheng ◽  
G.S. Gooris ◽  
A. Weerheim ◽  
M. Ponec
Keyword(s):  
Stratum Corneum ◽  
Stratum Corneum Lipid

Phase behaviour of model stratum corneum lipid mixtures: an infrared spectroscopy investigation

1998 ◽  
Vol 76 (11) ◽  
pp. 1501-1511 ◽  
Author(s):  
Michel Lafleur
Keyword(s):  
Infrared Spectroscopy ◽  
Stratum Corneum ◽  
Metastable Phase ◽  
Phase Behaviour ◽  
Stable Phase ◽  
Lipid Mixtures ◽  
External Agents ◽  
Stratum Corneum Lipid ◽  
Crystalline Domains

The stratum corneum, the top layer of the epidermis, is the material that constitutes the membrane enveloping our body. The lipids that are present are responsible for the permeability properties of the skin and, as a consequence, are essential to maintain the hydration of the internal components and to protect our body from external agents. In the present work, the mixing and the structural properties of model mixtures formed by the main lipids of the stratum corneum have been examined by infrared spectroscopy. The model is formed by an equimolar mixture of ceramides (type III), cholesterol, and perdeuterated palmitic acid. Binary mixtures as well as mixtures for which the ceramides were substituted by sphingomyelin, a ceramide precursor, have also been studied. The results indicate that the stratum corneum model mixture exhibits a rich polymorphism, ranging from crystalline domains with heterogeneous lipid composition and orthorhombic chain packing, to a fluid and homogeneous phase. To obtain this particular behaviour, the three components are essential and the specific role of each species is discussed. In addition, the results reveal that the homogeneous lipid distribution observed for temperatures higher than 70°C can be maintained at low temperatures, leading to the formation of a metastable phase. Several weeks are needed to obtain the thermodynamically stable phase if the sample is incubated at 5°C. However, it is rapidly induced by annealing the sample at 40°C.Key words: stratum corneum, lipid, infrared spectroscopy, ceramide.

Effect of microplasma treatment on stratum corneum lipid molecule

2020 ◽  
Vol 59 (SH) ◽  
pp. SHHF06
Author(s):  
J. Kristof ◽  
T. Aoshima ◽  
M. Blajan ◽  
K. Shimizu
Keyword(s):  
Stratum Corneum ◽  
Lipid Molecule ◽  
Stratum Corneum Lipid
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