Site-selective scission of human genome by artificial restriction DNA cutter

2009 ◽  
pp. 6542 ◽  
Author(s):  
Kenichiro Ito ◽  
Hitoshi Katada ◽  
Narumi Shigi ◽  
Makoto Komiyama
Keyword(s):  
Human Genome ◽  
Artificial Restriction ◽  
Site Selective

Artificial Restriction DNA Cutter Using Nuclease S1 for Site‐Selective Scission of Genomic DNA

2019 ◽  
pp. e72 ◽  
Author(s):  
Arivazhagan Rajendran ◽  
Narumi Shigi ◽  
Jun Sumaoka ◽  
Makoto Komiyama
Keyword(s):  
Genomic Dna ◽  
Nuclease S1 ◽  
Artificial Restriction ◽  
Site Selective

Artificial restriction DNA cutter for site-selective scission of double-stranded DNA with tunable scission site and specificity

2008 ◽  
Vol 3 (4) ◽  
pp. 655-662 ◽  
Author(s):  
Makoto Komiyama ◽  
Yuichiro Aiba ◽  
Yoji Yamamoto ◽  
Jun Sumaoka
Keyword(s):  
Double Stranded Dna ◽  
Artificial Restriction ◽  
Site Selective

Design of a nonviral vector for site‐selective, efficient integration into the human genome

2002 ◽  
Vol 16 (10) ◽  
pp. 1242-1247 ◽  
Author(s):  
Joseph M. Kaminski ◽  
Mark R. Huber ◽  
James B. Summers ◽  
Matthew B. Ward
Keyword(s):  
Human Genome ◽  
Nonviral Vector ◽  
Efficient Integration ◽  
Site Selective

scholarly journals Site-selective hydrolysis of huge DNA by artificial restriction DNA cutter

2006 ◽  
Vol 50 (1) ◽  
pp. 265-266
Author(s):  
Yoji Yamamoto ◽  
Kazuyuki Miura ◽  
Makoto Komiyama
Keyword(s):  
Selective Hydrolysis ◽  
Artificial Restriction ◽  
Site Selective ◽  
Hydrolysis Of

scholarly journals An artificial restriction DNA cutter for site-selective gene insertion in human cells

2013 ◽  
Vol 49 (60) ◽  
pp. 6764 ◽  
Author(s):  
Kenichiro Ito ◽  
Narumi Shigi ◽  
Makoto Komiyama
Keyword(s):  
Human Cells ◽  
Gene Insertion ◽  
Artificial Restriction ◽  
Site Selective

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

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