Sulfonate- or carboxylate-functionalized N-heterocyclic bis-carbene ligands and related water soluble silver complexes

2009 ◽  
pp. 6985 ◽  
Author(s):  
Grazia Papini ◽  
Maura Pellei ◽  
Giancarlo Gioia Lobbia ◽  
Alfredo Burini ◽  
Carlo Santini
Keyword(s):  
Water Soluble ◽  
Silver Complexes ◽  
Carbene Ligands

Synthesis and Characterization of Highly Water Soluble Ruthenium(II) and Osmium(II) Complexes Bearing Chelating Sulfonated N-Heterocyclic Carbene Ligands

2013 ◽  
Vol 32 (3) ◽  
pp. 741-744 ◽  
Author(s):  
Dominik Jantke ◽  
Mirza Cokoja ◽  
Alexander Pöthig ◽  
Wolfgang A. Herrmann ◽  
Fritz E. Kühn
Keyword(s):  
Water Soluble ◽  
Synthesis And Characterization ◽  
Carbene Ligands

Structural variation in silver complexes with N-heterocyclic carbene ligands bearing amido functionality

2008 ◽  
Vol 361 (9-10) ◽  
pp. 2973-2978 ◽  
Author(s):  
Chuang-Yi Liao ◽  
Kai-Ting Chan ◽  
Pei-Ling Chiu ◽  
Chih-Yuan Chen ◽  
Hon Man Lee
Keyword(s):  
Structural Variation ◽  
Silver Complexes ◽  
Carbene Ligands

scholarly journals Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

2012 ◽  
Vol 41 (13) ◽  
pp. 3720 ◽  
Author(s):  
Diana C. F. Monteiro ◽  
Roger M. Phillips ◽  
Benjamin D. Crossley ◽  
Jake Fielden ◽  
Charlotte E. Willans
Keyword(s):  
Silver Complexes ◽  
Carbene Ligands

Knight Shift in 13 C NMR Resonances Confirms the Coordination of N‐Heterocyclic Carbene Ligands to Water‐Soluble Palladium Nanoparticles

2016 ◽  
Vol 56 (3) ◽  
pp. 865-869 ◽  
Author(s):  
Juan M. Asensio ◽  
Simon Tricard ◽  
Yannick Coppel ◽  
Román Andrés ◽  
Bruno Chaudret ◽  
...  
Keyword(s):  
Palladium Nanoparticles ◽  
Knight Shift ◽  
Water Soluble ◽  
Carbene Ligands ◽  
C Nmr

scholarly journals Water-Soluble Gold(I) and Gold(III) Complexes with Sulfonated N-Heterocyclic Carbene Ligands: Synthesis, Characterization, and Application in the Catalytic Cycloisomerization of γ-Alkynoic Acids into Enol-Lactones

ACS Catalysis ◽  
2013 ◽  
Vol 3 (12) ◽  
pp. 3086-3098 ◽  
Author(s):  
Eder Tomás-Mendivil ◽  
Patrick Y. Toullec ◽  
Javier Borge ◽  
Salvador Conejero ◽  
Véronique Michelet ◽  
...  
Keyword(s):  
Water Soluble ◽  
Carbene Ligands

Water-Soluble Luminescent Cyclometalated Gold(III) Complexes withcis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties

2014 ◽  
Vol 20 (28) ◽  
pp. 8604-8614 ◽  
Author(s):  
Faan-Fung Hung ◽  
Wai-Pong To ◽  
Jing-Jing Zhang ◽  
Chensheng Ma ◽  
Wai-Yeung Wong ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Water Soluble ◽  
Carbene Ligands

scholarly journals Silver(I) Complexes of the Pharmaceutical Agents Metronidazole and 4-Hydroxymethylpyridine: Comparison of Cytotoxic Profile for Potential Clinical Application

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1949 ◽  
Author(s):  
Lidia Radko ◽  
Sylwia Stypuła-Trębas ◽  
Andrzej Posyniak ◽  
Dominik Żyro ◽  
Justyn Ochocki
Keyword(s):  
Silver Nitrate ◽  
Clinical Application ◽  
Hepg2 Cells ◽  
Membrane Damage ◽  
Membrane Integrity ◽  
Cellular Membrane ◽  
Water Soluble ◽  
Total Protein Content ◽  
Silver Complexes ◽  
Potential Clinical Application

In previous papers, we have reported on the high antifungal and significant antibacterial activity against Gram-positive and Gram-negative bacteria of the water-soluble silver(I) complexes of metronidazole and derivatives of pyridine compared to silver nitrate. In the present study, the cytotoxic activity of the silver(I) complexes of metronidazole and 4-hydroxymethylpyridine was compared with that of silver nitrate. Metronidazole and 4-hydroxymethylpyridine were investigated using Balb/c 3T3 and HepG2 cell lines in order to evaluate the potential clinical application of silver(I) complexes. The cells were exposed for 72 h to compounds at eight concentrations. The cytotoxic concentrations (IC50) of the study compounds were assessed within four biochemical endpoints: mitochondrial activity, lysosomal activity, cellular membrane integrity, and total protein content. The investigated silver(I) complexes displayed comparable cytotoxicity to that of silver nitrate used in clinics. Mean cytotoxic concentrations calculated for investigated silver(I) complexes from concentration–response curves ranged from 2.13 to 26.5 µM. HepG2 cells were less sensitive to the tested complexes compared to fibroblasts (Balb/c 3T3). However, the most affected endpoint for HepG2 cells was cellular membrane damage. The cytotoxicity of both silver complexes was comparable for Balb/c 3T3 cells. The cytotoxic potential of the new silver(I) compounds compared to that of silver nitrate used in medicine indicates that they are safe and could be used in clinical practice. The presented results are yet more stimulating to further studies that evaluate the therapeutic use of silver complexes.

scholarly journals Transmetalation from Magnesium–NHCs—Convenient Synthesis of Chelating π-Acidic NHC Complexes

Inorganics ◽  
2019 ◽  
Vol 7 (5) ◽  
pp. 65 ◽  
Author(s):  
Julian Messelberger ◽  
Annette Grünwald ◽  
Philipp Stegner ◽  
Laura Senft ◽  
Frank W. Heinemann ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Dimethyl Sulfoxide ◽  
Transition Metal Complexes ◽  
Silver Complexes ◽  
Reaction Intermediates ◽  
Carbene Ligands ◽  
Moisture Sensitivity ◽  
Convenient Synthesis

The synthesis of chelating N-heterocyclic carbene (NHC) complexes with considerable π-acceptor properties can be a challenging task. This is due to the dimerization of free carbene ligands, the moisture sensitivity of reaction intermediates or reagents, and challenges associated with the workup procedure. Herein, we report a general route using transmetalation from magnesium–NHCs. Notably, this route gives access to transition-metal complexes in quantitative conversion without the formation of byproducts. It therefore produces transition-metal complexes outperforming the conventional routes based on free or lithium-coordinated carbene, silver complexes, or in situ metalation in dimethyl sulfoxide (DMSO). We therefore propose transmetalation from magnesium–NHCs as a convenient and general route to obtain NHC complexes.

scholarly journals Silver complexes of ligands derived from adamantylamines: Water-soluble silver-donating compounds with antibacterial properties

2017 ◽  
Vol 168 ◽  
pp. 13-17 ◽  
Author(s):  
Jorge Jimenez ◽  
Indranil Chakraborty ◽  
Mauricio Rojas-Andrade ◽  
Pradip K. Mascharak
Keyword(s):  
Antibacterial Properties ◽  
Water Soluble ◽  
Silver Complexes
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