Layer-by-layer multilayer films linked with reversible boronate ester bonds with glucose-sensitivity under physiological conditions

Soft Matter ◽  
2009 ◽  
Vol 5 (11) ◽  
pp. 2302 ◽  
Author(s):  
Zhibo Ding ◽  
Ying Guan ◽  
Yongjun Zhang ◽  
X. X. Zhu
Keyword(s):  
Multilayer Films ◽  
Layer By Layer ◽  
Boronate Ester ◽  
Physiological Conditions ◽  
Glucose Sensitivity

scholarly journals Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1164 ◽  
Author(s):  
Kentaro Yoshida ◽  
Kazuma Awaji ◽  
Seira Shimizu ◽  
Miku Iwasaki ◽  
Yuki Oide ◽  
...  
Keyword(s):  
Boronic Acid ◽  
Oxidation Reaction ◽  
Shikimic Acid ◽  
Multilayer Films ◽  
Electrostatic Repulsion ◽  
Layer By Layer ◽  
Sensitive Layer ◽  
Boronate Ester ◽  
Physiological Conditions ◽  
Phenyl Boronic Acid

Hydrogen peroxide (H2O2)-sensitive layer-by-layer films were prepared based on combining phenyl boronic acid (PBA)-modified poly(allylamine) (PAH) with shikimic acid (SA)-modified-PAH through boronate ester bonds. These PBA-PAH/SA-PAH multilayer films could be prepared in aqueous solutions at pH 7.4 and 9.0 in the presence of NaCl. It is believed that the electrostatic repulsion between the SA-PAH and PBA-PAH was diminished and the formation of ester bonds between the SA and PBA was promoted in the presence of NaCl. These films readily decomposed in the presence of H2O2 because the boronate ester bonds were cleaved by an oxidation reaction. In addition, SA-PAH/PBA-PAH multilayer films combined with glucose oxidase (GOx) were decomposed in the presence of glucose because GOx catalyzes the oxidation of D-glucose to generate H2O2. The surfaces of CaCO3 microparticles were coated with PAH/GOx/(SA-PAH/PBA-PAH)5 films that absorbed insulin. A 1 mg quantity of these particles released up to 10 μg insulin in the presence 10 mM glucose under physiological conditions.

Biological Multilayer Films Assembled by Redox Polymer and HRP on Screen-Printed Carbon Electrode

2012 ◽  
Vol 571 ◽  
pp. 56-59
Author(s):  
Yu Fang Sha ◽  
Mei Zhao ◽  
Ming Quan Yang ◽  
Hai Xin Bai ◽  
Man Zhao
Keyword(s):  
Horseradish Peroxidase ◽  
Electrostatic Interaction ◽  
Electrode Surface ◽  
Multilayer Films ◽  
Carbon Electrode ◽  
Layer By Layer ◽  
Redox Polymer ◽  
Screen Printed Carbon Electrode ◽  
Positively Charged ◽  
Screen Printed

Biological multilayer films of redox polymer and horseradish peroxidase (HRP) were successfully assembled on a screen-printed carbon electrode using layer-by-layer (LBL) assembled method based on the electrostatic interaction. The screen-printed carbon electrode surface was modified by the positively charged redox polymer, and the negatively charged HRP by LBL method.

Multilayer Films Fabricated from Oppositely Charged Polyphenylene Dendrimers by Electrostatic Layer-by-Layer Assembly

2005 ◽  
Vol 206 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Dong Ha Kim ◽  
Jose Luis Hernandez-Lopez ◽  
Jianyun Liu ◽  
George Mihov ◽  
Linjie Zhi ◽  
...  
Keyword(s):  
Multilayer Films ◽  
Layer By Layer ◽  
Layer By Layer Assembly ◽  
Oppositely Charged ◽  
Polyphenylene Dendrimers ◽  
Layer Assembly

scholarly journals Deposition Mechanisms in Layer-by-Layer or Step-by-Step Deposition Methods: From Elastic and Impermeable Films to Soft Membranes with Ion Exchange Properties

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Marc Michel ◽  
Valérie Toniazzo ◽  
David Ruch ◽  
Vincent Ball
Keyword(s):  
Short Review ◽  
Multilayer Films ◽  
Film Deposition ◽  
Layer By Layer ◽  
Operational Parameters ◽  
Polyelectrolyte Multilayer ◽  
Interacting Species ◽  
Growth Regime ◽  
Versatile Tool ◽  
Solid Liquid

The modification of solid-liquid interfaces with polyelectrolyte multilayer films appears as a versatile tool to confer new functionalities to surfaces in environmentally friendly conditions. Indeed such films are deposited by alternate dipping of the substrates in aqueous solutions containing the interacting species or spraying these solutions on the surface of the substrate. Spin coating is more and more used to produce similar films. The aim of this short review article is to provide an unifying picture about the deposition mechanisms of polyelectrolyte multilayer films. Often those films are described as growing either in a linear or in a supralinear growth regime with the number of deposited “layer pairs”. The growth regime of PEM films can be controlled by operational parameters like the temperature or the ionic strength of the used solutions. The control over the growth regime of the films as a function of the number of deposition steps allows to control their functional properties: either hard and impermeable films in the case of linear growth or soft and permeable films in the case of supralinear growth. Such different properties can be obtained with a given combination of interacting species by changing the operational parameters during the film deposition.

Layer-by-layer self-assembly of multilayer films based on humic acid

2011 ◽  
Vol 519 (13) ◽  
pp. 4324-4328 ◽  
Author(s):  
Zhengxia Xu ◽  
Chenyang Hu ◽  
Hu Guoxin
Keyword(s):  
Humic Acid ◽  
Self Assembly ◽  
Multilayer Films ◽  
Layer By Layer
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