Influence of the chloride concentration on ligand substitution reactions of [Pt(SMC)Cl2] with biologically relevant nucleophiles

2009 ◽  
pp. 4526 ◽  
Author(s):  
Tanja Soldatović ◽  
Živadin D. Bugarčić ◽  
Rudi van Eldik
Keyword(s):  
Chloride Concentration ◽  
Ligand Substitution ◽  
Substitution Reactions ◽  
Biologically Relevant ◽  
Ligand Substitution Reactions

scholarly journals Impact of Chloride Concentration on Ligand Substitution Reactions of Zinc(II) Complexes with Biologically Relevant Nitrogen Nucleophiles

2018 ◽  
Vol 43 (3-4) ◽  
pp. 244-253 ◽  
Author(s):  
Enisa Selimović ◽  
Tanja Soldatović
Keyword(s):  
Complex Anion ◽  
Ligand Substitution ◽  
Octahedral Complex ◽  
Coordination Geometry ◽  
Substitution Reactions ◽  
Biologically Relevant ◽  
Additional Coordination ◽  
Nitrogen Nucleophiles ◽  
Metal Ligand ◽  
Ligand Substitution Reactions

The mole-ratio method was used to determine the metal–ligand stoichiometry between [ZnCl2(en)] and [ZnCl2(terpy)] (where en = 1,2-diaminoethane or ethylenediamine and terpy = 2,2′:6′,2″-terpyridine) and imidazole at pH 7.2 in the presence of different chloride concentrations. The results indicated step-wise formation of 1:1 and 1:2 complexes in the presence of 0.010 M NaCl and 1:1 complexes in the presence of 0.001 M NaCl for the [ZnCl2(en)] complex. These results are correlated with additional coordination of chlorides in the first coordination sphere and with changes in coordination geometry. In the presence of 0.001 M NaCl the five-coordinate complex anion [ZnCl3(en)]- is formed initially and then a substitution reaction with imidazole occurs. In the presence of 0.010 M NaCl the octahedral complex anion [ZnCl4(en)]2- is formed. Additional coordination of chloride in the [ZnCl2(terpy)] complex is not found and the metal–ligand stoichiometry is 1:2. The kinetics of ligand substitution reactions of zinc(II) complexes and biologically relevant nitrogen nucleophiles such as imidazole, 1,2,3-triazole and L-histidine were investigated at pH 7.2 as a function of nucleophile concentration in the presence of 0.001 M and 0.010 M NaCl. The reactions were followed under pseudo first-order conditions by UV-Vis spectrophotometry. The substitution reactions included two steps of consecutive displacement of chlorido ligands with changes only in the coordination geometry of the [ZnCl2(en)] complex. The order of reactivity of the investigated nucleophiles for the first reaction step towards both complexes was L-histidine > 1,2,3-triazole > imidazole, while in the presence of 0.010 M NaCl the most reactive ligand was 1,2,3-triazole towards the [ZnCl2(en)] complex.

scholarly journals Physical properties, ligand substitution reactions, and biological activity of Co(iii)-Schiff base complexes

2019 ◽  
Vol 48 (18) ◽  
pp. 5987-6002 ◽  
Author(s):  
A. Paden King ◽  
Hendryck A. Gellineau ◽  
Samantha N. MacMillan ◽  
Justin J. Wilson
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Physical Properties ◽  
Ligand Exchange ◽  
Ligand Substitution ◽  
Schiff Base Complexes ◽  
Substitution Reactions ◽  
Anticancer Properties ◽  
Ligand Substitution Reactions

A subset of fluorinated Co(iii) Schiff base complexes was synthesized, and their structural, ligand exchange, and anticancer properties were investigated.

Dinuclear nitrido-bridged ruthenium complexes bearing diimine ligands

2017 ◽  
Vol 46 (41) ◽  
pp. 14256-14263 ◽  
Author(s):  
Julie Urgiles ◽  
Sarah R. Nathan ◽  
Samantha N. MacMillan ◽  
Justin J. Wilson
Keyword(s):  
Calcium Uptake ◽  
Ruthenium Complexes ◽  
Ligand Substitution ◽  
Mitochondrial Calcium ◽  
Substitution Reactions ◽  
Uptake Inhibition ◽  
Diimine Ligands ◽  
Mitochondrial Calcium Uptake ◽  
Ligand Substitution Reactions

Nitrido-bridged ruthenium complexes are synthesized via ligand substitution reactions and evaluated for mitochondrial calcium uptake inhibition.

Axial ligand substitution reactions of iron(II) phthalocyanine adducts

1980 ◽  
Vol 19 (7) ◽  
pp. 2162-2165 ◽  
Author(s):  
Jens Martinsen ◽  
Michael Miller ◽  
Daria Trojan ◽  
D. A. Sweigart
Keyword(s):  
Ligand Substitution ◽  
Axial Ligand ◽  
Substitution Reactions ◽  
Ligand Substitution Reactions
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