Di-platinum complexes containing thiolato-urea ligands: structural and anion binding studies

2009 ◽  
pp. 2974 ◽  
Author(s):  
Carolina Mendoza ◽  
Jordi Benet-Buchholz ◽  
Miquel A. Pericás ◽  
Ramón Vilar
Keyword(s):  
Platinum Complexes ◽  
Anion Binding ◽  
Binding Studies

Calix[n]bipyrroles: Synthesis, Characterization, and Anion-Binding Studies

2003 ◽  
Vol 42 (20) ◽  
pp. 2278-2281 ◽  
Author(s):  
Jonathan L. Sessler ◽  
Deqiang An ◽  
Won-Seob Cho ◽  
Vincent Lynch
Keyword(s):  
Anion Binding ◽  
Binding Studies

Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors

2010 ◽  
Vol 16 (30) ◽  
pp. 9123-9131 ◽  
Author(s):  
Xiaoming He ◽  
Fernando Herranz ◽  
Eddie Chung-Chin Cheng ◽  
Ramon Vilar ◽  
Vivian Wing-Wah Yam
Keyword(s):  
Anion Binding ◽  
Binding Studies ◽  
Design Synthesis ◽  
Thiolate Complexes

Bis(platinum) complexes containing two platinum cis-diammine units. Synthesis and initial DNA-binding studies

1988 ◽  
Vol 110 (15) ◽  
pp. 5018-5019 ◽  
Author(s):  
Nicholas P. Farrell ◽  
Sergio G. De Almeida ◽  
Kirsten A. Skov
Keyword(s):  
Dna Binding ◽  
Platinum Complexes ◽  
Binding Studies ◽  
Dna Binding Studies

Stability, Water Exchange, and Anion Binding Studies on Lanthanide(III) Complexes with a Macrocyclic Ligand Based on 1,7-Diaza-12-crown-4: Extremely Fast Water Exchange on the Gd3+Complex

2009 ◽  
Vol 48 (18) ◽  
pp. 8878-8889 ◽  
Author(s):  
Zoltán Pálinkás ◽  
Adrián Roca-Sabio ◽  
Marta Mato-Iglesias ◽  
David Esteban-Gómez ◽  
Carlos Platas-Iglesias ◽  
...  
Keyword(s):  
Water Exchange ◽  
Macrocyclic Ligand ◽  
Anion Binding ◽  
Binding Studies

Synthesis, structural characterization and anion binding studies of palladium macrocycles with hydrogen-bonding ligands

2007 ◽  
pp. 3516 ◽  
Author(s):  
Pilar Diaz ◽  
Jorge A. Tovilla ◽  
Pablo Ballester ◽  
Jordi Benet-Buchholz ◽  
Ramón Vilar
Keyword(s):  
Hydrogen Bonding ◽  
Structural Characterization ◽  
Anion Binding ◽  
Binding Studies

scholarly journals Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes

2020 ◽  
Vol 13 (10) ◽  
pp. 284
Author(s):  
Claudia Riccardi ◽  
Domenica Capasso ◽  
Angela Coppola ◽  
Chiara Platella ◽  
Daniela Montesarchio ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Synergistic Effects ◽  
Polyacrylamide Gel Electrophoresis ◽  
Platinum Complexes ◽  
Cancer Cell Lines ◽  
Cd Spectroscopy ◽  
Model Systems ◽  
Binding Studies

We here report our studies on the reaction with the platinum(II) ion of a nucleoamino acid constituted by the l-2,3-diaminopropanoic acid linked to the thymine nucleobase through a methylenecarbonyl linker. The obtained new platinum complexes, characterized by spectroscopic and mass spectrometric techniques, were envisaged to exploit synergistic effects due to the presence of both the platinum center and the nucleoamino acid moiety. The latter can be potentially useful to protect the complexes from early deactivation, as well as to facilitate their cell internalization. The biological activity of the complexes in terms of antiproliferative effects was evaluated in vitro on different cancer cell lines and healthy cells, showing the best results on human cervical adenocarcinoma (HeLa) cells along with good selectivity for cancer over normal cells. In contrast, the metal-free nucleoamino acid did not show any cytotoxicity on both normal and cancer cell lines. Finally, the ability of the novel Pt(II) complexes to bind various DNA model systems was investigated by circular dichroism (CD) spectroscopy and polyacrylamide gel electrophoresis analyses proving that the newly obtained compounds can potentially target DNA, similarly to other well-known anticancer Pt complexes, with a peculiar G-quadruplex vs. duplex selectivity.

scholarly journals The multifunctional oxidase activity of ceruloplasmin as revealed by anion binding studies

1999 ◽  
Vol 265 (2) ◽  
pp. 589-597 ◽  
Author(s):  
Giovanni Musci ◽  
Gian C. Bellenchi ◽  
Lilia Calabrese
Keyword(s):  
Oxidase Activity ◽  
Anion Binding ◽  
Binding Studies
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