Sonogashira and “Click” reactions for the N-terminal and side-chain functionalization of peptides with [Mn(CO)3(tpm)]+-based CO releasing molecules (tpm = tris(pyrazolyl)methane)

2009 ◽  
pp. 4292 ◽  
Author(s):  
Hendrik Pfeiffer ◽  
Alfonso Rojas ◽  
Johanna Niesel ◽  
Ulrich Schatzschneider
Keyword(s):  
Side Chain ◽  
Click Reactions

scholarly journals Sequential nucleophilic “click” reactions for functional amphiphilic homopolymers

2019 ◽  
Vol 10 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Huan He ◽  
Bin Liu ◽  
Meizhe Wang ◽  
Richard W. Vachet ◽  
S. Thayumanavan
Keyword(s):  
Side Chain ◽  
Click Reactions ◽  
Amphiphilic Homopolymers

Sequential introduction of two side-chain functionalities is achieved with nucleophilic “click”.

Modular synthesis of glycopolymers with well-defined sugar units in the side chain via Ugi reaction and click chemistry: hetero vs. homo

2016 ◽  
Vol 7 (25) ◽  
pp. 4263-4271 ◽  
Author(s):  
Lulu Xue ◽  
Xinhong Xiong ◽  
Kui Chen ◽  
Yafei Luan ◽  
Gaojian Chen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Ugi Reaction ◽  
Side Chain ◽  
Click Reactions ◽  
Modular Synthesis

Modularized glycopolymers were prepared via Ugi and click reactions, and used as models to investigate their binding abilities.

Synthesis of Side-Chain Modified Peptides Using Iterative Solid Phase ‘Click' Methodology

2017 ◽  
Vol 70 (2) ◽  
pp. 201 ◽  
Author(s):  
Xuejian Liu ◽  
Robert B. P. Elmes ◽  
Katrina A. Jolliffe
Keyword(s):  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Anion Recognition ◽  
Iterative Sequence ◽  
Side Chain ◽  
Short Peptides ◽  
Click Reactions ◽  
Fluorescent Indicators ◽  
Modified Peptides ◽  
Recognition Motifs

A series of side-chain modified peptides have been prepared via an iterative sequence of peptide couplings and azide–alkyne cycloadditions (‘click’ reactions) using Fmoc-solid phase peptide synthesis. This efficient modular synthetic route allows the systematic and sequential incorporation of a variety of side-chain modifications onto short peptides. The versatility of this approach was demonstrated by the synthesis of a series of short peptides with appended anion recognition motifs and fluorescent indicators.

Arginine side-chain modification that occurs during copper-catalysed azide–alkyne click reactions resembles an advanced glycation end product

2016 ◽  
Vol 14 (26) ◽  
pp. 6205-6211 ◽  
Author(s):  
Anne C. Conibear ◽  
Karine Farbiarz ◽  
Rupert L. Mayer ◽  
Maria Matveenko ◽  
Hanspeter Kählig ◽  
...  
Keyword(s):  
Side Chain ◽  
Advanced Glycation ◽  
Click Reactions ◽  
Advanced Glycation End Product ◽  
Arginine Side Chain

An adduct of dehydroascorbate with arginine forms during copper-catalysed azide–alkyne click reactions and resembles an advanced glycation end product.

Electroluminescent properties of side-chain naphthalimide-derivated polymers

1998 ◽  
Vol 95 (6) ◽  
pp. 1351-1354 ◽  
Author(s):  
C.-M. Bouché ◽  
P. Le Barny ◽  
H. Facoetti ◽  
F. Soyer ◽  
P. Robin
Keyword(s):  
Side Chain

Evidence for Impaired Hepatic Vitamin K1 Metabolism in Patients Treated with N-Methyl-Thiotetrazole Cephalosporins

1984 ◽  
Vol 51 (03) ◽  
pp. 358-361 ◽  
Author(s):  
H Bechtold ◽  
K Andrassy ◽  
E Jähnchen ◽  
J Koderisch ◽  
H Koderisch ◽  
...  
Keyword(s):  
Protein C ◽  
Oral Intake ◽  
Bleeding Complications ◽  
Side Chain ◽  
Acute Administration ◽  
Vitamin K1 ◽  
New Class ◽  
Parenteral Alimentation ◽  
Hepatocellular Regeneration ◽  
Echis Carinatus

SummaryIn 8 patients on no oral intake and with parenteral alimentation, administration of cephalosporins with N-methyl-thiotetrazole side chain (moxalactam, cefamandole), was associated with prolongation of prothrombin time, appearance in the circulation of descarboxy-prothrombin (counter immunoelectrophoresis and echis carinatus assay) and diminution of protein C. Acute administration of 10 mg vitamin Ki was followed by the transient appearance of vitamin K1 2,3-epoxide, indicating an impaired hepatocellular regeneration of vitamin K1 from the epoxide. Impaired hepatic vitamin K1 metabolism, tentatively ascribed to the N-methyl-thiotetrazole group, is one (but possibly not the only) cause of bleeding complications and depression of vitamin K1dependent procoagulants in patients treated with the new class of cephalosporins.

METABOLISM OF 17α-HYDROXYPROGESTERONE-4-14C-17α-CAPROATE BY HOMOGENATES OF RAT LIVER AND HUMAN PLACENTA

1961 ◽  
Vol 36 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Margaret Wiener ◽  
Charles I. Lupa ◽  
E. Jürgen Plotz
Keyword(s):  
Rat Liver ◽  
Human Placenta ◽  
Steric Hindrance ◽  
Placental Tissue ◽  
Caproic Acid ◽  
Major Product ◽  
Side Chain ◽  
Anaerobic Conditions ◽  
Prolonged Action ◽  
Long Acting

ABSTRACT 17α-hydroxyprogesterone-4-14C-17α-caproate (HPC), a long-acting progestational agent, was incubated with homogenates of rat liver and human placenta. The rat liver was found to reduce Ring A of HPC under anaerobic conditions to form allopregnane-3β,17α-diol-20-one-17α-caproate and pregnane-3β,17α-diol-20-one-17α-caproate, the allopregnane isomer being the major product. The caproic acid ester was neither removed nor altered during the incubation. Placental tissue did not attack HPC under conditions where the 20-ketone of progesterone was reduced. It is postulated that this absence of attack on the side chain is due to steric hindrance from the caproate ester, and that this may account for the prolonged action of HPC.

P450 side-chain cleavage enzyme autoantibodies in canine Addison's disease

2013 ◽  
pp. 1-1
Author(s):  
Alisdair Boag ◽  
Kerry McLaughlin ◽  
Mike Christie ◽  
Peter Graham ◽  
Harriet Syme ◽  
...  
Keyword(s):  
Addison’S Disease ◽  
Side Chain ◽  
Addison's Disease ◽  
Side Chain Cleavage ◽  
Chain Cleavage ◽  
Cleavage Enzyme
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