Nanoparticle assisted magnetic resonance imaging of the early reversible stages of amyloid β self-assembly

2008 ◽  
pp. 2197 ◽  
Author(s):  
Jin-sil Choi ◽  
Hyuck Jae Choi ◽  
Dae Chul Jung ◽  
Joo-Hyuk Lee ◽  
Jinwoo Cheon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Self Assembly ◽  
Amyloid Β ◽  
Resonance Imaging

Self-Assembly of SiO2/Gd-DTPA-Polyethylenimine Nanocomposites as Magnetic Resonance Imaging Probes

2010 ◽  
Vol 10 (1) ◽  
pp. 540-548 ◽  
Author(s):  
Kui Luo ◽  
Jing Tian ◽  
Gang Liu ◽  
Jiayu Sun ◽  
Chunchao Xia ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Self Assembly ◽  
Resonance Imaging ◽  
Imaging Probes

scholarly journals Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy

2019 ◽  
Vol 18 (12) ◽  
pp. 1376-1383 ◽  
Author(s):  
Yue Yuan ◽  
Jia Zhang ◽  
Xiaoliang Qi ◽  
Shuoguo Li ◽  
Guanshu Liu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Self Assembly ◽  
Resonance Imaging ◽  
Tumour Therapy

Tumor Acid Microenvironment-Triggered Self-Assembly of ESIONPs for T1/T2 Switchable Magnetic Resonance Imaging

2020 ◽  
Vol 3 (11) ◽  
pp. 7752-7761
Author(s):  
Yilin He ◽  
Zheng Mao ◽  
Ye Zhang ◽  
Haiyin Lv ◽  
Jincong Yan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Self Assembly ◽  
Resonance Imaging

Colloidal Amphiphile Self-Assembly Particles Composed of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging

Langmuir ◽  
2010 ◽  
Vol 26 (4) ◽  
pp. 2383-2391 ◽  
Author(s):  
Guozhen Liu ◽  
Charlotte E. Conn ◽  
Lynne J. Waddington ◽  
Stephen T. Mudie ◽  
Calum J. Drummond
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Self Assembly ◽  
Resonance Imaging

scholarly journals Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1362 ◽  
Author(s):  
Daijiro Yanagisawa ◽  
Nor Faeizah Ibrahim ◽  
Hiroyasu Taguchi ◽  
Shigehiro Morikawa ◽  
Takami Tomiyama ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Amyloid Β ◽  
Resonance Imaging ◽  
Aβ Oligomers ◽  
Keto Form ◽  
19F Mri ◽  
The Brain ◽  
Curcumin Derivative

Recent evidence suggests that the formation of soluble amyloid β (Aβ) aggregates with high toxicity, such as oligomers and protofibrils, is a key event that causes Alzheimer’s disease (AD). However, understanding the pathophysiological role of such soluble Aβ aggregates in the brain in vivo could be difficult due to the lack of a clinically available method to detect, visualize, and quantify soluble Aβ aggregates in the brain. We had synthesized a novel fluorinated curcumin derivative with a fixed keto form, named as Shiga-Y51, which exhibited high selectivity to Aβ oligomers in vitro. In this study, we investigated the in vivo detection of Aβ oligomers by fluorine-19 (19F) magnetic resonance imaging (MRI) using Shiga-Y51 in an APP/PS1 double transgenic mouse model of AD. Significantly high levels of 19F signals were detected in the upper forebrain region of APP/PS1 mice compared with wild-type mice. Moreover, the highest levels of Aβ oligomers were detected in the upper forebrain region of APP/PS1 mice in enzyme-linked immunosorbent assay. These findings suggested that 19F-MRI using Shiga-Y51 detected Aβ oligomers in the in vivo brain. Therefore, 19F-MRI using Shiga-Y51 with a 7 T MR scanner could be a powerful tool for imaging Aβ oligomers in the brain.

Bifunctional nanocapsules for magnetic resonance imaging and photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104731-104734 ◽  
Author(s):  
Hecheng Zhang ◽  
Shan Peng ◽  
Suying Xu ◽  
Zhengguang Chen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Photodynamic Therapy ◽  
Magnetic Resonance ◽  
Self Assembly ◽  
Resonance Imaging ◽  
Bifunctional Protein

A bifunctional protein nanospheres was successfully constructed through self-assembly of hydrolysed α-lactalbumin for magnetic resonance imaging and photodynamic therapy.

scholarly journals Delayed clearance of cerebrospinal fluid tracer from choroid plexus in idiopathic normal pressure hydrocephalus

2019 ◽  
Vol 40 (9) ◽  
pp. 1849-1858 ◽  
Author(s):  
Per Kristian Eide ◽  
Lars Magnus Valnes ◽  
Are Hugo Pripp ◽  
Kent-Andre Mardal ◽  
Geir Ringstad
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebrospinal Fluid ◽  
Magnetic Resonance ◽  
Choroid Plexus ◽  
Normal Pressure Hydrocephalus ◽  
Amyloid Β ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Resonance Imaging ◽  
Lateral Ventricles

Impaired clearance of amyloid-β from choroid plexus is one proposed mechanism behind amyloid deposition in Alzheimer's disease. The present study examined whether clearance from choroid plexus of a cerebrospinal fluid tracer, serving as a surrogate marker of a metabolic waste product, is altered in idiopathic normal pressure hydrocephalus (iNPH), one sub-type of dementia. In a prospective observational study of close to healthy individuals (reference cohort; REF) and individuals with iNPH, we performed standardized T1-weighted magnetic resonance imaging scans before and through 24 h after intrathecal administration of a cerebrospinal fluid tracer (the magnetic resonance imaging contrast agent gadobutrol). Changes in normalized T1 signal within the choroid plexus and cerebrospinal fluid of lateral ventricles were quantified using FreeSurfer. The normalized T1 signal increased to maximum within choroid plexus and cerebrospinal fluid of lateral ventricles 6–9 h after intrathecal gadobutrol in both the REF and iNPH cohorts (enrichment phase). Peak difference in normalized T1 signals between REF and iNPH individuals occurred after 24 h (clearance phase). The results gave evidence for gadobutrol resorption from cerebrospinal fluid by choroid plexus, but with delay in iNPH patients. Whether choroid plexus has a role in iNPH pathogenesis in terms of delayed clearance of amyloid-β remains to be shown.

scholarly journals C-Reactive Protein, Plasma Amyloid-β Levels, and Their Interaction With Magnetic Resonance Imaging Markers

Stroke ◽  
2018 ◽  
Vol 49 (11) ◽  
pp. 2692-2698 ◽  
Author(s):  
Saima Hilal ◽  
M. Arfan Ikram ◽  
Marcel M. Verbeek ◽  
Oscar H. Franco ◽  
Erik Stoops ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Amyloid Β ◽  
Resonance Imaging ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Imaging Markers
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