scholarly journals C-Reactive Protein, Plasma Amyloid-β Levels, and Their Interaction With Magnetic Resonance Imaging Markers

Stroke ◽  
2018 ◽  
Vol 49 (11) ◽  
pp. 2692-2698 ◽  
Author(s):  
Saima Hilal ◽  
M. Arfan Ikram ◽  
Marcel M. Verbeek ◽  
Oscar H. Franco ◽  
Erik Stoops ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Amyloid Β ◽  
Resonance Imaging ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Imaging Markers

Serum C-reactive Protein Levels Demonstrate Predictive Value for Radiographic and Magnetic Resonance Imaging Outcomes in Patients with Active Ankylosing Spondylitis Treated with Golimumab

2016 ◽  
Vol 43 (9) ◽  
pp. 1704-1712 ◽  
Author(s):  
Jürgen Braun ◽  
Xenofon Baraliakos ◽  
Kay-Geert A. Hermann ◽  
Stephen Xu ◽  
Benjamin Hsu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ankylosing Spondylitis ◽  
Magnetic Resonance ◽  
Radiographic Progression ◽  
Resonance Imaging ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Link Type ◽  
Increased Risk ◽  
Serum Crp

Objective.Serum C-reactive protein (CRP) associates with radiographic progression in patients with ankylosing spondylitis (AS) untreated with tumor necrosis factor (TNF) antagonists. We assessed correlations between serum CRP and radiographic progression/magnetic resonance imaging (MRI)-detected inflammation after 2 years of anti-TNF therapy.Methods.Patients with active AS receiving golimumab (GOL)/placebo through Week 16 (early escape) or Week 24 (crossover by design), followed by GOL through 4 years, had sera/images obtained through Week 208. Lateral spinal radiographs and spinal MRI were scored with the modified Stoke AS Spine Score (mSASSS) and the AS spine MRI activity (ASspiMRI-a) score, respectively. ANOVA assessed differences based on CRP levels and mSASSS progression. The relationships between CRP levels and mSASSS/ASspiMRI-a were assessed by Spearman correlation and logistic regression.Results.Of the randomized GO-RAISE patients, 299 (84.0%) had pre- and posttreatment spinal radiographs. Larger proportions of patients with Week 104 CRP ≥ 0.5 mg/dl (n = 47) versus < 0.5 mg/dl (n = 236, 40.4% vs 22.9%, p = 0.0121) had mSASSS changes ≥ 2 at Week 104. Across several visits, serum CRP demonstrated weak associations with mSASSS change (rs ≤ 0.21, p < 0.05, n = 262–293) and moderate associations with ASspiMRI-a change (rs = −0.33 to 0.54, p < 0.05, n = 65–89). Higher baseline CRP was associated with increased risk for syndesmophytes at Week 104/Week 208, and large, short-term decreases in CRP from baseline to Week 14/Week 24 also yielded increased syndesmophyte formation risk.Conclusion.Elevated CRP after 2 years of anti-TNF treatment correlated with greater radiographic progression risk at 4 years. Elevated CRP at baseline or Week 14/Week 24 of anti-TNF treatment weakly predicted subsequent radiographic progression and modestly predicted residual spinal inflammation in patients with AS treated with anti-TNF. Findings are useful regarding new treatment options in patients treated with anti-TNF. ClinicalTrials.gov: NCT00265083.

scholarly journals Intraplaque hemorrhage assessed by high-resolution magnetic resonance imaging and C-reactive protein in carotid atherosclerosis

2007 ◽  
Vol 46 (6) ◽  
pp. 1130-1137 ◽  
Author(s):  
Luciano Cabral Albuquerque ◽  
Luciane Barreneche Narvaes ◽  
Aluísio Antunes Maciel ◽  
Henrique Staub ◽  
Maurício Friedrich ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Carotid Atherosclerosis ◽  
Intraplaque Hemorrhage ◽  
Resonance Imaging ◽  
C Reactive Protein ◽  
Reactive Protein
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