A new class of functionalized polyoxometalates: synthesis, structure and preliminary antitumor activity studies of three arylimido substituted hexamolybdates bearing a strong electron-withdrawing nitro group, (Bu4N)2[Mo6O18(NAr)] (Ar = 3-NO2-C6H4, 2-CH3-4-NO2-C6H3, 2-CH3-5-NO2-C6H3)

2008 ◽  
pp. 4770 ◽  
Author(s):  
Sijia Xue ◽  
An Chai ◽  
Zhijuan Cai ◽  
Yongge Wei ◽  
Changsheng Xiang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Nitro Group ◽  
Strong Electron ◽  
New Class

Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines

1994 ◽  
Vol 37 (25) ◽  
pp. 4329-4337 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Alberto Leoni ◽  
Barbara Cacciari ◽  
Stefano Manfredini ◽  
Daniele Simoni ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
New Class

scholarly journals Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux

2014 ◽  
Vol 13 (6) ◽  
pp. 1410-1418 ◽  
Author(s):  
Nihed Draoui ◽  
Olivier Schicke ◽  
Emmanuel Seront ◽  
Caroline Bouzin ◽  
Pierre Sonveaux ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
New Class

Designing enhanced and ratiometric probes for detecting OCl− based on substituents influencing the fluorescence of HBT and their application in strips and bioimaging

The Analyst ◽  
2020 ◽  
Vol 145 (17) ◽  
pp. 5933-5939
Author(s):  
Xiaodong Sun ◽  
Fanyong Yan ◽  
Yingxia Jiang ◽  
Hao Zhang ◽  
Zhonghui Sun ◽  
...  
Keyword(s):  
Nitro Group ◽  
Cell Imaging ◽  
Strong Electron ◽  
Test Strips ◽  
Ratiometric Probes

Based on strong electron-withdrawing effect of nitro group to powerfully influence the fluorescence of fluorophores, enhanced and ratiometric probes were synthesize to detect OCl− for portable test strips and cell imaging.

Effect of Meta-Substitution on Solid State Geometry of N-(Aryl)-2,2,2-trichloro-acetamides, 3-XC6H4NH-CO-CCl3 and 3,5-X2C6H3NH-CO-CCl3 (X = Cl, CH3)

2007 ◽  
Vol 62 (1-2) ◽  
pp. 91-100
Author(s):  
Basavalinganadoddy Thimme Gowda ◽  
Jozef Kožíšek ◽  
Ingrid Svoboda ◽  
Hartmut Fuess
Keyword(s):  
Solid State ◽  
Crystal Structures ◽  
Nitro Group ◽  
Room Temperature ◽  
Asymmetric Unit ◽  
Strong Electron ◽  
Space Group ◽  
Lattice Constants ◽  
Crystal System ◽  
Electron Withdrawing Group

The crystal structures of N-(meta-substituted phenyl)-2,2,2-trichloro-acetamides such as N- (3-methylphenyl)-2,2,2-trichloro-acetamide, 3-CH3C6H4NH-CO-CCl3 (3MPTCA); N-(3-chlorophenyl)- 2,2,2-trichloro-acetamide, 3-ClC6H4NH-CO-CCl3 (3CPTCA); N-(3,5-dimethylphenyl)- 2,2,2-trichloro-acetamide, 3,5-(CH3)2C6H3NH-CO-CCl3 (35DMPTCA) and N-(3,5-dichlorophenyl)- 2,2,2-trichloro-acetamide, 3,5-Cl2C6H3NH-CO-CCl3 (35DCPTCA) have been determined at room temperature. The crystal system, space group, formula units and lattice constants (Å ) of the new structures are: 3MPTCA: orthorhombic, Pbca, Z = 8, a = 12.3199(11), b = 8.9719(8), c = 20.2058(15); 3CPTCA: orthorhombic, Fdd2, Z =16, a=19.285(4), b=40.765(8), c=5.5920(11); 35DMPTCA: triclinic, P1̄, Z = 2, a = 8.994(4), b = 9.9890(10), c = 14.760(5), α = 79.56(2)°, β = 73.32(3)°, γ = 86.47(2)°; and 35DCPTCA: orthorhombic, Pbca, Z = 8, a = 22.485(5), b=10.738(2), c=10.028(3). The compound 35DMPTCA has two molecules in its asymmetric unit, similar to o-NO2-, m-NO2- and p-CH3-substituted phenyl-trichloro-acetamides, while 3MPTCA, 3CPTCA and 35DCPTCA have one molecule each in their asymmetric units. The analysis of data indicates that the substitution of a strong electron withdrawing group such as a nitro group into PTCA at ortho or meta positions has a significant effect on the crystal parameters.

A new class of nitrosoureas. 4. Synthesis and antitumor activity of disaccharide derivatives of 3,3-disubstituted 1-(2-chloroethyl)-1-nitrosoureas

1982 ◽  
Vol 25 (4) ◽  
pp. 441-446 ◽  
Author(s):  
Kenji Tsujihara ◽  
Masakatsu Ozeki ◽  
Tamio Morikawa ◽  
Masatoshi Kawamori ◽  
Yukio Akaike ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
New Class ◽  
Derivatives Of

scholarly journals 3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity

ChemMedChem ◽  
2016 ◽  
Vol 11 (16) ◽  
pp. 1700-1704 ◽  
Author(s):  
Loana Musso ◽  
Raffaella Cincinelli ◽  
Valentina Zuco ◽  
Michelandrea De Cesare ◽  
Franco Zunino ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
New Class

A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor Activity

2001 ◽  
Vol 44 (2) ◽  
pp. 138-144 ◽  
Author(s):  
John Mann ◽  
Anne Baron ◽  
Yaw Opoku-Boahen ◽  
Eric Johansson ◽  
Gary Parkinson ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
New Class ◽  
Binding Agents
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