Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications

2008 ◽  
Vol 37 (5) ◽  
pp. 912 ◽  
Author(s):  
X.-M. Qian ◽  
S. M. Nie
Keyword(s):  
Single Molecule ◽  
Biomedical Applications ◽  
Single Nanoparticle

scholarly journals Nucleic acid-based nanoengineering: novel structures for biomedical applications

2011 ◽  
Vol 1 (5) ◽  
pp. 702-724 ◽  
Author(s):  
Hanying Li ◽  
Thomas H. LaBean ◽  
Kam W. Leong
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Single Molecule ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Base Pairs ◽  
Single Molecule Level ◽  
Stimulus Responsive ◽  
Bioactive Agents ◽  
Novel Structures

Nanoengineering exploits the interactions of materials at the nanometre scale to create functional nanostructures. It relies on the precise organization of nanomaterials to achieve unique functionality. There are no interactions more elegant than those governing nucleic acids via Watson–Crick base-pairing rules. The infinite combinations of DNA/RNA base pairs and their remarkable molecular recognition capability can give rise to interesting nanostructures that are only limited by our imagination. Over the past years, creative assembly of nucleic acids has fashioned a plethora of two-dimensional and three-dimensional nanostructures with precisely controlled size, shape and spatial functionalization. These nanostructures have been precisely patterned with molecules, proteins and gold nanoparticles for the observation of chemical reactions at the single molecule level, activation of enzymatic cascade and novel modality of photonic detection, respectively. Recently, they have also been engineered to encapsulate and release bioactive agents in a stimulus-responsive manner for therapeutic applications. The future of nucleic acid-based nanoengineering is bright and exciting. In this review, we will discuss the strategies to control the assembly of nucleic acids and highlight the recent efforts to build functional nucleic acid nanodevices for nanomedicine.

Single-molecule spectroscopy

2017 ◽  
Author(s):  
Michel Orrit
Keyword(s):  
Nonlinear Optics ◽  
Single Molecule ◽  
Single Molecules ◽  
Super Resolution ◽  
Optical Methods ◽  
Single Molecule Spectroscopy ◽  
New Techniques ◽  
Single Nanoparticle ◽  
Cell Biologist ◽  
Sensitivity And Selectivity

This chapter gives an overview of the main optical methods used to detect and study single molecules and other small objects (nano-objects). Much of the work so far has exploited the excellent sensitivity and selectivity of fluorescence, but several new techniques, mostly based on nonlinear optics, have recently reached the single-molecule or single-nanoparticle regime. The chapter briefly discusses some results with reference to published reviews. Single-molecule techniques have now been incorporated into the arsenal of the physico-chemist and the cell biologist. However, the recent development of super-resolution techniques and of new labels suggests that further progress can be expected from measurements on single nano-objects in the next few years.

Synthetic Glass Nanopore for Single Molecule Detection

2012 ◽  
Vol 229-231 ◽  
pp. 197-200
Author(s):  
Xiu Hua Sun ◽  
Chang Lu Gao ◽  
Li Qun Gu
Keyword(s):  
Pore Structure ◽  
Single Molecule ◽  
Second Messengers ◽  
Single Molecule Detection ◽  
Target Species ◽  
Single Nanoparticle ◽  
Molecular Scale ◽  
Drug Compounds ◽  
Target Molecules ◽  
Nanopore Sensors

The molecular-scale pore structure, called nanopore, interacting with target molecules in its functionalized lumen, can produce characteristic changes in the pore conductance, which allows us to identify single molecules and simultaneously quantify each target species in the mixture. Nanopore sensors have been created for tremendous biomedical detections, with targets ranging from metal ions, drug compounds and cellular second messengers, to proteins and DNAs. Here we will review our recent discoveries with a lab-in-hand glass nanopore: single-molecule discrimination of chiral enantiomers with a trapped cyclodextrin, sensing of bioterrorist agent ricin and site-directed capturing a single nanoparticle.

A unique dual fluorescence emission in solid-state from small molecule based on phenanthrocarbazole with AIE luminogen as single-molecule white-light emissive material

2021 ◽  
Author(s):  
Jirat Chatsirisupachai ◽  
Phattananawee Nalaoh ◽  
Chokchai Kaiyasuan ◽  
Pongsakorn Chasing ◽  
Taweesak Sudyoadsuk ◽  
...  
Keyword(s):  
Solid State ◽  
Small Molecule ◽  
Single Molecule ◽  
White Light ◽  
Biomedical Applications ◽  
Organic Molecules ◽  
Fluorescence Emission ◽  
Dual Fluorescence ◽  
Emissive Property

Purely organic molecules with dual emissive property have received increased attention in the last decade as they are now being utilized in practical optoelectronic, sensing and biomedical applications. We presented...

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