The future of proteomic analysis in biological systems and molecular medicine

2007 ◽  
Vol 3 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Steven J. Bark ◽  
Vivian Hook
Keyword(s):  
Proteomic Analysis ◽  
Biological Systems ◽  
Molecular Medicine ◽  
The Future

Freeze-fracture cytochemistry: A goal set by Russell Steere in 1957

1993 ◽  
Vol 51 ◽  
pp. 60-61
Author(s):  
Nicholas J Severs
Keyword(s):  
Chemical Nature ◽  
Biological Systems ◽  
Freeze Fracture ◽  
Structural Components ◽  
Major Goal ◽  
Membrane Biology ◽  
Routine Application ◽  
The Future ◽  
Freeze Etching

In his pioneering demonstration of the potential of freeze-etching in biological systems, Russell Steere assessed the future promise and limitations of the technique with remarkable foresight. Item 2 in his list of inherent difficulties as they then stood stated “The chemical nature of the objects seen in the replica cannot be determined”. This defined a major goal for practitioners of freeze-fracture which, for more than a decade, seemed unattainable. It was not until the introduction of the label-fracture-etch technique in the early 1970s that the mould was broken, and not until the following decade that the full scope of modern freeze-fracture cytochemistry took shape. The culmination of these developments in the 1990s now equips the researcher with a set of effective techniques for routine application in cell and membrane biology.Freeze-fracture cytochemical techniques are all designed to provide information on the chemical nature of structural components revealed by freeze-fracture, but differ in how this is achieved, in precisely what type of information is obtained, and in which types of specimen can be studied.

Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches

2014 ◽  
pp. 29-70
Author(s):  
Elena Silvestri ◽  
Assunta Lombardi ◽  
Pieter De Lange ◽  
Daniela Glinni ◽  
Rosalba Senese ◽  
...  
Keyword(s):  
Biological Systems ◽  
Molecular Medicine

scholarly journals Understanding Hydrogen Sulfide in Inflammation: Opportunities and Challenges

2019 ◽  
Author(s):  
Madhav Bhatia
Keyword(s):  
Hydrogen Sulfide ◽  
Tissue Damage ◽  
Adaptive Response ◽  
Inflammatory Diseases ◽  
Biological Systems ◽  
Future Prospects ◽  
Disease Research ◽  
The Future

Inflammation is an adaptive response to injury, but uncontrolled inflammation can lead to tissue damage and disease. Research in our laboratory (since confirmed in different laboratories worldwide) has shown that hydrogen sulfide (H2S) acts as a mediator of inflammation in different disease conditions. Learning about a novel mediator of inflammation results in unique opportunities with which to approach inflammatory diseases. At the same time, the complexity of biological systems and translation of research from the bed to the bedside also presents challenges. This Editorial aims to discuss the opportunities and challenges in relation to the role of H2S in inflammation, and the future prospects for this research.

7. The lawless pursuit of biological systems

2020 ◽  
pp. 108-122
Author(s):  
Eberhard O. Voit
Keyword(s):  
Systems Biology ◽  
Biological Systems ◽  
Large Classes ◽  
The Future

The laws of physics are a prerequisite for us to make reliable predictions regarding our surroundings. By extension, making reliable predictions in biology requires laws of biology. The problem is that such laws are almost non-existent, because biological systems are hugely complex and diverse. As a consequence, it is difficult to make true statements covering all organisms on Earth—or even large classes of organisms. This difficulty translates directly into the challenge of identifying rules that govern biological systems. What would such biological rules or laws even look like? ‘The lawless pursuit of biological systems’ considers the future of systems biology and discusses how it might evolve as it matures as a field of investigation.

scholarly journals LIVING NATURE AS A SOURCE OF IDEAS FOR NEW PRODUCT SOLUTIONS

2007 ◽  
Vol 1 ◽  
pp. 36
Author(s):  
Bernd Hill
Keyword(s):  
Process Development ◽  
Biological Systems ◽  
New Product ◽  
Construction Process ◽  
Innovation Potential ◽  
Development Teams ◽  
The Future ◽  
Living Nature ◽  
Development Engineer

The future of enterprises depends among other things also on its rate of innovation. Particularly for the development of product ideas the innovation potential of living nature is used hardly or insufficiently during the construction process. Development teams orient themselves still too little at the evolution regularities and structure principles of biological systems. Orienting at the regularities of the evolution of biological systems as well as at the efficient principles of operation, structure and organization of living nature could supply various suggestions for new product ideas. For this reason the author of this contribution conceived a construction bionics, which helps the development engineer to use living nature systematically and purposefully as source of inspiration.

scholarly journals Proteomic analysis methods and their role in the diagnosis of obstetric and gynecological pathology

2019 ◽  
Vol 68 (1) ◽  
pp. 69-82
Author(s):  
Nina G. Sazonova ◽  
Tatyana A. Makarenko ◽  
Raisa Ya. Olovyannikova ◽  
Viktor A. Kutyakov ◽  
Alla B. Salmina
Keyword(s):  
Protein Expression ◽  
Current Literature ◽  
Proteomic Analysis ◽  
Research Method ◽  
Biological Systems ◽  
Diagnosis And Treatment ◽  
Proteomic Profiling ◽  
Gynecological Diseases ◽  
Comprehensive Study

The article presents current literature on proteomic profiling and the role of proteomic technologies in the diagnosis of various obstetric and gynecological diseases. Proteomic analysis is a promising research method, as it allows for a comprehensive study of protein expression and its regulation in the biological systems, which opens up new opportunities for a more in-depth and detailed study of the etiology and pathogenesis, as well as timely diagnosis and treatment of obstetric and gynecological pathology.

scholarly journals Biomimicry in textiles: past, present and potential. An overview

2011 ◽  
Vol 8 (59) ◽  
pp. 761-775 ◽  
Author(s):  
Leslie Eadie ◽  
Tushar K. Ghosh
Keyword(s):  
Thermal Insulation ◽  
Interdisciplinary Research ◽  
Biological Systems ◽  
Natural World ◽  
Self Healing ◽  
Functional Systems ◽  
General Overview ◽  
Functional Surfaces ◽  
Holistic Understanding ◽  
The Future

The natural world around us provides excellent examples of functional systems built with a handful of materials. Throughout the millennia, nature has evolved to adapt and develop highly sophisticated methods to solve problems. There are numerous examples of functional surfaces, fibrous structures, structural colours, self-healing, thermal insulation, etc., which offer important lessons for the textile products of the future. This paper provides a general overview of the potential of bioinspired textile structures by highlighting a few specific examples of pertinent, inherently sustainable biological systems. Biomimetic research is a rapidly growing field and its true potential in the development of new and sustainable textiles can only be realized through interdisciplinary research rooted in a holistic understanding of nature.

X-ray Detection on Fe-H Vibrations

2010 ◽  
Vol 1262 ◽  
Author(s):  
Hongxin Wang ◽  
Yisong Guo ◽  
Saeed Kamali ◽  
Stephen P Cramer
Keyword(s):  
Vibrational Spectroscopy ◽  
Biological Systems ◽  
Nuclear Resonance ◽  
Vibrational Modes ◽  
Model Complexes ◽  
X Ray ◽  
Nuclear Resonance Vibrational Spectroscopy ◽  
The Future ◽  
Scattering Factor

AbstractX-ray detection on hydrogen related events is difficult due to its extremely small scattering factor. In this report, we have used nuclear resonance vibrational spectroscopy (NRVS) to examine the nature of the Fe–H vibrational modes in several FeH model complexes, which shines light on the possible measurements on the Fe-H vibrations inside real biological systems in the future.

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