scholarly journals Molecular Medicine: The Future of Biomedical Science and Clinical Practice

1994 ◽  
Vol 1 (1) ◽  
pp. 1-1
Author(s):  
Anthony Cerami ◽  
Kenneth S. Warren
Keyword(s):  
Clinical Practice ◽  
Molecular Medicine ◽  
Biomedical Science ◽  
The Future

Venous Thromboembolism: Genetics and Thrombophilias

2021 ◽  
Vol 42 (02) ◽  
pp. 271-283
Author(s):  
Manila Gaddh ◽  
Rachel P. Rosovsky
Keyword(s):  
Clinical Practice ◽  
Venous Thromboembolism ◽  
Family History ◽  
Morbidity And Mortality ◽  
Inherited Thrombophilia ◽  
Risks And Benefits ◽  
Hereditary Thrombophilia ◽  
The World ◽  
The Future ◽  
History Of

AbstractVenous thromboembolism (VTE) is a major cause of morbidity and mortality throughout the world. Up to one half of patients who present with VTE will have an underlying thrombophilic defect. This knowledge has led to a widespread practice of testing for such defects in patients who develop VTE. However, identifying a hereditary thrombophilia by itself does not necessarily change outcomes or dictate therapy. Furthermore, family history of VTE by itself can increase an asymptomatic person's VTE risk several-fold, independent of detecting a known inherited thrombophilia. In this article, we will describe the current validated hereditary thrombophilias including their history, prevalence, and association with VTE. With a focus on evaluating both risks and benefits of testing, we will also explore the controversies of why, who, and when to test as well as discuss contemporary societal guidelines. Lastly, we will share how these tests have been integrated into clinical practice and how to best utilize them in the future.

Collaborative Research: Once More Into the Breach

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 510-511
Author(s):  
EVAN CHARNEY
Keyword(s):  
Clinical Practice ◽  
Clinical Research ◽  
Collaborative Research ◽  
Molecular Level ◽  
Organ System ◽  
Biomedical Science ◽  
Memorial Hospital ◽  
Narrow Focus ◽  
Higher Power ◽  
Practice Based Research

In this issue, Christoffel and associates1 described a new program of practice-based research involving community pediatricians and the Department of Pediatrics at Children's Memorial Hospital in Chicago. In one sense, all clinical research is practice based and has a long and honorable history in medicine. What has changed is that the gap between those who conduct research and those in clinical practice has widened. As the pathophysiology of diseases is better understood, the frontier of biomedical science has moved from the whole patient to the organ system, the cell, and, now, the molecular level. It is as if each generation of researchers has snapped a progressively higher power lens under the microscope, with a deeper but more narrow focus.

The future of aerobic exercise testing in clinical practice: is it the ultimate vital sign?

2010 ◽  
Vol 6 (3) ◽  
pp. 325-342 ◽  
Author(s):  
Ross Arena ◽  
Jonathan Myers ◽  
Marco Guazzi
Keyword(s):  
Clinical Practice ◽  
Aerobic Exercise ◽  
Exercise Testing ◽  
Vital Sign ◽  
The Future

scholarly journals Psychiatry in the future

2004 ◽  
Vol 28 (8) ◽  
pp. 277-278
Author(s):  
Frank Holloway
Keyword(s):  
Mental Health ◽  
Clinical Practice ◽  
Evidence Based Medicine ◽  
Cochrane Collaboration ◽  
Routine Clinical Practice ◽  
Evidence Based ◽  
Policy Makers ◽  
The Future ◽  
The Cochrane Collaboration ◽  
Based Medicine

In an era of evidence-based medicine, policy-makers and researchers are preoccupied by the task of ensuring that advances in research are implemented in routine clinical practice. This preoccupation has spawned a small but growing research industry of its own, with the development of resources such as the Cochrane Collaboration database and journals such as Evidence-Based Mental Health. In this paper, I adopt a philosophically quite unfashionable methodology – introspection – to address the question: how has research affected my practice?

Pharmacogenomics and Precision Psychiatry

2018 ◽  
pp. 96-102
Author(s):  
Julia C. Stingl ◽  
Gonzalo Laje
Keyword(s):  
Genetic Variation ◽  
Clinical Practice ◽  
Drug Therapy ◽  
Mechanisms Of Action ◽  
Molecular Medicine ◽  
Evidence Based ◽  
Broad Definition ◽  
Clinical Syndromes ◽  
Definition Of ◽  
Future Work

Molecular medicine has opened new possibilities of personalized approaches in drug therapy. The development of evidence-based pharmacogenetic guidelines to steer therapy has slowly entered the field of psychiatric therapeutics. Some of the reasons behind the limited progress in psychiatric pharmacogenomics include the broad definition of clinical syndromes, limited knowledge of psychiatric pathophysiology, and limited understanding of psychotropics’ mechanisms of action. Pharmacogenomic markers have been reported for both pharmacodynamic and pharmacokinetic genes. However, only genetic variation in pharmacokinetic genes has shown to be helpful in clinical practice. There is little consensus as to when and if pharmacogenetic tests should be used in psychiatry. There are limited evidence-based dosing guidelines available for actionable gene–drug pairs. Future work in psychiatry may deepen our understanding of the biological underpinnings of psychiatric syndromes and provide the potential for individual tailored therapies.

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