A microfluidic device for continuous, real time blood plasma separation

Lab on a Chip ◽  
2006 ◽  
Vol 6 (7) ◽  
pp. 871-880 ◽  
Author(s):  
Sung Yang ◽  
Akif Ündar ◽  
Jeffrey D. Zahn
Keyword(s):  
Blood Plasma ◽  
Real Time ◽  
Microfluidic Device ◽  
Plasma Separation ◽  
Blood Plasma Separation

Biological Fluid Separation in Microfluidic Channels Using Flow Rate Control

2005 ◽  
Author(s):  
Sung Yang ◽  
Akif U¨ndar ◽  
Jeffrey D. Zahn
Keyword(s):  
Blood Plasma ◽  
Real Time ◽  
Microfluidic Device ◽  
Numerical Study ◽  
Biological Fluid ◽  
Microfluidic Channels ◽  
Defibrinated Sheep Blood ◽  
Plasma Separation ◽  
Study Results ◽  
Blood Plasma Separation

A microfluidic device for continuous, real time blood plasma separation is introduced. This device is composed of a blood inlet, a purified plasma outlet, and a concentrated blood cell outlet. It is designed to separate blood plasma from an initial blood sample of up to 45 % hematocrit (Hct). The microfluidic device is designed and analyzed using an analogous electrical circuit, analytical and numerical studies. The numerical study results show that 27 % and 25 % of plasma volume can be separated from a total inlet blood volume of 45 % and 39 % hematocrit, respectively. The functionality of this device was demonstrated using defibrinated sheep blood (Hct=36 %). During 2 hrs. of continuous blood infusion through the device, all the blood cells traveled through the device toward the concentrated blood outlet while only the plasma flowed towards the plasma outlet without any clogging or lysis of cells. The experimentally measured plasma skimming volume was about 33 % for a 36 % inlet hematocrit. Due to the device’s simple structure and control mechanism, this microdevice is expected to be used for highly efficient continuous, real time cell-free blood plasma separation device.

A passive two-way microfluidic device for low volume blood-plasma separation

2019 ◽  
Vol 209 ◽  
pp. 28-34 ◽  
Author(s):  
L. Spigarelli ◽  
V. Bertana ◽  
D. Marchisio ◽  
L. Scaltrito ◽  
S. Ferrero ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Microfluidic Device ◽  
Plasma Separation ◽  
Volume Blood ◽  
Low Volume ◽  
Blood Plasma Separation

EDTA-treated cotton-thread microfluidic device used for one-step whole blood plasma separation and assay

Lab on a Chip ◽  
2016 ◽  
Vol 16 (8) ◽  
pp. 1492-1504 ◽  
Author(s):  
Mokhamad Fakhrul Ulum ◽  
Leni Maylina ◽  
Deni Noviana ◽  
Dedy Hermawan Bagus Wicaksono
Keyword(s):  
Blood Plasma ◽  
Microfluidic Device ◽  
Whole Blood ◽  
Plasma Separation ◽  
Cotton Thread ◽  
One Step ◽  
Blood Plasma Separation

Whole blood plasma separation and assay using EDTA-treated cotton thread.

High flow rate microfluidic device for blood plasma separation using a range of temperatures

Lab on a Chip ◽  
2010 ◽  
Vol 10 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Angeles Ivón Rodríguez-Villarreal ◽  
Martin Arundell ◽  
Manuel Carmona ◽  
Josep Samitier
Keyword(s):  
Blood Plasma ◽  
Microfluidic Device ◽  
Flow Rate ◽  
High Flow ◽  
High Flow Rate ◽  
Plasma Separation ◽  
Blood Plasma Separation
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