Crystal engineering or crystal mysticism? A case study

Joel S. Miller

doi:10.1039/b507527k

Dynamic molecular recognition in the generation of a new crystal-engineering motif: a unique case study of a dicarboxylic acid with a ditopic receptor favouring a polymeric over a dimeric hydrogen-bonded supramolecular complex

Tetrahedron Letters ◽

10.1016/j.tetlet.2005.08.078 ◽

2005 ◽

Vol 46 (42) ◽

pp. 7187-7191 ◽

Cited By ~ 21

Author(s):

Shyamaprosad Goswami ◽

Swapan Dey ◽

Hoong-Kun Fun ◽

Shazia Anjum ◽

Atta-ur-Rahman

Keyword(s):

Molecular Recognition ◽

Dicarboxylic Acid ◽

Crystal Engineering ◽

Supramolecular Complex ◽

Unique Case ◽

Ditopic Receptor ◽

Hydrogen Bonded

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Competing hydrogen bonding and halogen bonding interactions in crystal engineering: A case study of bi-functional donor molecules

Chemical Physics ◽

10.1016/j.chemphys.2014.07.002 ◽

2014 ◽

Vol 441 ◽

pp. 30-37 ◽

Cited By ~ 12

Author(s):

Hairong Ding ◽

Yunxiang Lu ◽

Weihong Wu ◽

Honglai Liu

Keyword(s):

Hydrogen Bonding ◽

Crystal Engineering ◽

Halogen Bonding

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Crystal Engineering of Nanomorphology for Complex Oxide Materials via Thermal Decomposition of Metal−Organic Frameworks. Case Study of Sodium Tantalate

Crystal Growth & Design ◽

10.1021/cg101456w ◽

2011 ◽

Vol 11 (4) ◽

pp. 1238-1243 ◽

Cited By ~ 13

Author(s):

Giovana G. Nunes ◽

Gulaim A. Seisenbaeva ◽

Vadim G. Kessler

Keyword(s):

Thermal Decomposition ◽

Crystal Engineering ◽

Metal Organic Frameworks ◽

Complex Oxide ◽

Oxide Materials ◽

Metal Organic

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Can crystal engineering be as beneficial as micronisation and overcome its pitfalls?: A case study with cilostazol

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2015.06.009 ◽

2015 ◽

Vol 491 (1-2) ◽

pp. 26-34 ◽

Cited By ~ 11

Author(s):

Kodukula Sai Gouthami ◽

Dinesh Kumar ◽

Rajesh Thipparaboina ◽

Rahul B. Chavan ◽

Nalini R. Shastri

Keyword(s):

Crystal Engineering

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Comparison of the polymorphs and solvates of two analogous fungicides—a case study of the applicability of a supramolecular synthon approach in crystal engineering

CrystEngComm ◽

10.1039/c1ce05077j ◽

2011 ◽

Vol 13 (15) ◽

pp. 4956 ◽

Cited By ~ 16

Author(s):

Elisa Nauha ◽

Antti Ojala ◽

Maija Nissinen ◽

Heidi Saxell

Keyword(s):

Crystal Engineering ◽

Supramolecular Synthon

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Supramolecular Architectures of Meloxicam Carboxylic Acid Cocrystals, a Crystal Engineering Case Study

Crystal Growth & Design ◽

10.1021/cg100514g ◽

2010 ◽

Vol 10 (10) ◽

pp. 4401-4413 ◽

Cited By ~ 92

Author(s):

Miranda L. Cheney ◽

David R. Weyna ◽

Ning Shan ◽

Mazen Hanna ◽

Lukasz Wojtas ◽

...

Keyword(s):

Carboxylic Acid ◽

Crystal Engineering ◽

Supramolecular Architectures

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Effects of Crystal Form on Solubility and Pharmacokinetics: A Crystal Engineering Case Study of Lamotrigine

Crystal Growth & Design ◽

10.1021/cg901010v ◽

2010 ◽

Vol 10 (1) ◽

pp. 394-405 ◽

Cited By ~ 170

Author(s):

Miranda L. Cheney ◽

Ning Shan ◽

Elisabeth R. Healey ◽

Mazen Hanna ◽

Lukasz Wojtas ◽

...

Keyword(s):

Crystal Engineering ◽

Crystal Form

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Crystal engineering: a case study using the 24 kDa fragment of the DNA gyrase B subunit from Escherichia coli

Acta Crystallographica Section D Biological Crystallography ◽

10.1107/s0907444999008136 ◽

1999 ◽

Vol 55 (9) ◽

pp. 1623-1625 ◽

Cited By ~ 20

Author(s):

Allan D'Arcy ◽

Martine Stihle ◽

Dirk Kostrewa ◽

Glenn Dale

Keyword(s):

Escherichia Coli ◽

Amino Acid ◽

Crystal Engineering ◽

Dna Gyrase ◽

Site Directed Mutagenesis ◽

Crystal Quality ◽

Single Amino Acid ◽

Wild Type ◽

B Subunit

Site-directed mutagenesis was used to determine the efficacy of changing surface residues to improve crystal quality. Nine mutants of the 24 kDa fragment of the Escherichia coli DNA gyrase B subunit were produced, changing residues on the protein's surface. The mutations changed either the charge or the polarity of the wild-type amino acid. It was found that single amino-acid changes on the surface could have a dramatic effect on the crystallization properties of the protein and generally resulted in an improvement in the number of crystal-screen hits as well as an improvement in crystal quality. It is concluded that crystal engineering is a valuable tool for protein crystallography.

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