Supramolecular Architectures of Meloxicam Carboxylic Acid Cocrystals, a Crystal Engineering Case Study

2010 ◽  
Vol 10 (10) ◽  
pp. 4401-4413 ◽  
Author(s):  
Miranda L. Cheney ◽  
David R. Weyna ◽  
Ning Shan ◽  
Mazen Hanna ◽  
Lukasz Wojtas ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Crystal Engineering ◽  
Supramolecular Architectures

Organic crystal engineering with piperazine-2,5-diones. 2. Crystal packing of weakly dipolar piperazinediones derived from 2-amino-4-bromo-7-methoxyindan-2-carboxylic acid

Tetrahedron ◽  
1999 ◽  
Vol 55 (50) ◽  
pp. 14301-14322 ◽  
Author(s):  
Lawrence J. Williams ◽  
B. Jagadish ◽  
Michael G. Lansdown ◽  
Michael D. Carducci ◽  
Eugene A. Mash
Keyword(s):  
Carboxylic Acid ◽  
Crystal Engineering ◽  
Crystal Packing ◽  
Organic Crystal

scholarly journals Surface-controlled dissolution rates: a case study of nanoceria in carboxylic acid solutions

2019 ◽  
Vol 6 (5) ◽  
pp. 1478-1492 ◽  
Author(s):  
Eric A. Grulke ◽  
Matthew J. Beck ◽  
Robert A. Yokel ◽  
Jason M. Unrine ◽  
Uschi M. Graham ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Acid Solutions ◽  
Dissolution Rates ◽  
Therapeutic Applications

Nanoparticle dissolution in local milieu can affect its ecotoxicity and therapeutic applications.

Can crystal engineering be as beneficial as micronisation and overcome its pitfalls?: A case study with cilostazol

2015 ◽  
Vol 491 (1-2) ◽  
pp. 26-34 ◽  
Author(s):  
Kodukula Sai Gouthami ◽  
Dinesh Kumar ◽  
Rajesh Thipparaboina ◽  
Rahul B. Chavan ◽  
Nalini R. Shastri
Keyword(s):  
Crystal Engineering

Supramolecular architectures in two 1:1 cocrystals of 5-fluorouracil with 5-bromothiophene-2-carboxylic acid and thiophene-2-carboxylic acid

2017 ◽  
Vol 73 (6) ◽  
pp. 481-485 ◽  
Author(s):  
Marimuthu Mohana ◽  
Packianathan Thomas Muthiah ◽  
Colin D. McMillen
Keyword(s):  
Solid State ◽  
Carboxylic Acid ◽  
Hydrogen Bonds ◽  
Crystal Structures ◽  
X Ray Diffraction ◽  
Base Pairs ◽  
X Ray ◽  
Supramolecular Architectures ◽  
Acid Acid ◽  
Carboxylic Acid Dimer

In solid-state engineering, cocrystallization is a strategy actively pursued for pharmaceuticals. Two 1:1 cocrystals of 5-fluorouracil (5FU; systematic name: 5-fluoro-1,3-dihydropyrimidine-2,4-dione), namely 5-fluorouracil–5-bromothiophene-2-carboxylic acid (1/1), C5H3BrO2S·C4H3FN2O2, (I), and 5-fluorouracil–thiophene-2-carboxylic acid (1/1), C4H3FN2O2·C5H4O2S, (II), have been synthesized and characterized by single-crystal X-ray diffraction studies. In both cocrystals, carboxylic acid molecules are linked through an acid–acid R 2 2(8) homosynthon (O—H...O) to form a carboxylic acid dimer and 5FU molecules are connected through two types of base pairs [homosynthon, R 2 2(8) motif] via a pair of N—H...O hydrogen bonds. The crystal structures are further stabilized by C—H...O interactions in (II) and C—Br...O interactions in (I). In both crystal structures, π–π stacking and C—F...π interactions are also observed.

Crystal engineering or crystal mysticism? A case study

CrystEngComm ◽  
2005 ◽  
Vol 7 (75) ◽  
pp. 458 ◽  
Author(s):  
Joel S. Miller
Keyword(s):  
Crystal Engineering
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