Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides

2005 ◽  
Vol 3 (8) ◽  
pp. 1520 ◽  
Author(s):  
Gianluigi Luppi ◽  
Andrea Garelli ◽  
Luca Prodi ◽  
Quirinus B. Broxterman ◽  
Bernard Kaptein ◽  
...  
Keyword(s):  
Calcium Receptors

The effect of vasodilator drugs on the noradrenaline constrictor response in the isolated mesenteric artery

1969 ◽  
Vol 47 (8) ◽  
pp. 663-669 ◽  
Author(s):  
John H. McNeill ◽  
Rex V. Barnes ◽  
Ronald S. Davis ◽  
Jerry B. Hook
Keyword(s):  
Mesenteric Artery ◽  
Calcium Release ◽  
Drug Induced ◽  
Calcium Dependent ◽  
Alpha Adrenergic Receptors ◽  
Vasoconstrictor Response ◽  
Dependent Inhibition ◽  
Calcium Receptors ◽  
Constrictor Response ◽  
Do So

Previous reports have indicated that diazoxide will inhibit the vasoconstrictor response to noradrenaline on isolated aortic strips (Wohl et al. Life Sci. 7, 381 (1968)). Inhibition of the noradrenaline response was dependent on the calcium concentrations. The present study has confirmed this observation in an isolated perfused mesenteric artery preparation. In addition, a calcium-dependent inhibition of the noradrenaline constrictor response was found with theophylline and sodium nitrite but isoproterenol did not inhibit the noradrenaline response. It is suggested that the drugs which inhibit noradrenaline may do so by either blocking calcium receptors or by depleting an intracellular calcium pool necessary for drug-induced vasoconstriction; or by preventing calcium release from such a pool. Blockade of alpha adrenergic receptors is probably not involved since the drugs also blocked the constrictor response to vasopressin. The mechanism of the inhibitory action of these drugs is probably not related to their effects on cyclic AMP.

Effect of doxorubicin on calcium receptors of myocardial cells

1989 ◽  
Vol 21 ◽  
pp. 87-88
Author(s):  
E. Monti ◽  
L. Paracchini ◽  
G. Perletti
Keyword(s):  
Myocardial Cells ◽  
Calcium Receptors

“Calcium receptors” on eukaryotic cells with special reference to the osteoclast

1990 ◽  
Vol 10 (6) ◽  
pp. 493-507 ◽  
Author(s):  
Mone Zaidi
Keyword(s):  
Special Reference ◽  
Cell Function ◽  
Extracellular Calcium ◽  
Eukaryotic Cells ◽  
Common Theme ◽  
Intracellular Signals ◽  
Recent Developments ◽  
Recent Addition ◽  
Intracellular Signal ◽  
Calcium Receptors

There is a growing list of cells that are capable of detecting and responding to changes in the concentration of extracellular calcium. The two classic examples of this behaviour are the calcitonin-secreting parafollicular cells of the thyroid and parathyroid hormone-secreting chief cells of the parathyroid gland. A more recent addition to this list is the renin-secreting juxtaglomerular cell of the kidney. Particularly intriguing has been independently the discovery by two laboratories, that the resorptive cell of bone, the osteoclast, is capable of detecting changes in ambient calcium. A common theme amongst all these so called “calcium-responsive” cells is that extracellular calcium increases elevate intracellular calcium levels, and this intracellular signal is either stimulatory or inhibitory to the functional response. But how these cells detect changes in the concentration of extracellular calcium, and how these recognition events are subsequently transformed into intracellular signals that regulate cell function are somewhat less clear. The commentary reveals some recent developments that seemingly provide insights into these mechanisms, with special reference to the osteoclast.

scholarly journals A case of severe neonatal hyperparathyroidism due to defect in calcium receptors

2010 ◽  
Vol 56 (4) ◽  
pp. 27-33
Author(s):  
A V Vitebskaia ◽  
E E Petriaĭkina ◽  
A Iu Razumovskiĭ ◽  
A A Pavlov ◽  
A N Tiul'pakov
Keyword(s):  
Clinical Symptoms ◽  
Molecular Genetic ◽  
Familial Hypocalciuric Hypercalcemia ◽  
General Health Status ◽  
Casr Gene ◽  
Patient Diagnosis ◽  
First Case ◽  
High Calcium ◽  
Calcium Receptors ◽  
Very High

The first case of severe neonatal hyperparathyroidism in the Russian population verified by molecular-genetic testing is described. The patient presented with very high calcium and parathyroid hormone (PTH) levels and showed characteristic clinical symptoms of hyperparathyroidism in the absence of lesions in long tubular bones. Removal of all parathyroid glands resulted in normalization of laboratory parameters and general health status of the patient. Diagnosis of severe neonatal hyperparathyroidism was confirmed by sequencing the CASR gene while parents of the child were shown to suffer familial hypocalciuric hypercalcemia.

Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis

2013 ◽  
Vol 125 (2) ◽  
pp. 67-75 ◽  
Author(s):  
Giovanni Sansoè ◽  
Manuela Aragno ◽  
Raffaella Mastrocola ◽  
Claudia Paternostro ◽  
Maurizio Parola
Keyword(s):  
Liver Cirrhosis ◽  
Arterial Pressure ◽  
Portal Pressure ◽  
Hormonal Status ◽  
Experimental Cirrhosis ◽  
Indirect Immunofluorescence Staining ◽  
Carbon Tetrachloride Administration ◽  
Specific Stimulation ◽  
And Function ◽  
Calcium Receptors

In rats with experimental liver cirrhosis, the kidney contains reduced amounts of membrane-bound CaRs (calcium-sensing receptors), and the specific stimulation of CaRs causes the generation of PGE2 (prostaglandin E2), renal vasodilation and increased natriuresis. CaR content and function in the liver of cirrhotic rats are unknown. To assess the activity of this Ca2+-dependent vasomotor system, we evaluated the effects of intravenous administration of PolyAg (poly-L-arginine), a selective CaR agonist, on hormonal status, portal haemodynamics, MAP (mean arterial pressure) in rats with liver cirrhosis induced by chronic CCl4 (carbon tetrachloride) administration. Two groups of eight control rats received intravenously 1 ml of 5% (w/v) glucose solution alone or containing 0.5 mg of PolyAg; two groups of ten cirrhotic rats were administered vehicle or PolyAg. Compared with controls, at baseline cirrhotic rats showed higher portal pressure (P<0.01), lower estimated functional liver plasma flow, measured as CICG (Indocyanine Green clearance) (P<0.03) and reduced hepatic protein content of CaRs (P<0.03), which were located mainly in sub-endothelial layers of portal venules and in myofibroblasts of fibrotic septa (immunohistochemistry and indirect immunofluorescence staining of liver sections). In cirrhotic animals, 0.5 mg of PolyAg decreased portal pressure (P<0.01) and increased CICG (P<0.05), without effects on arterial pressure and hormonal status. In conclusion, the present study provides evidence that in experimental cirrhosis agonists of liver CaRs elicit beneficial portal hypotensive effects by reducing intrahepatic resistance to portal flow. Moreover, these drugs are devoid of effects on systemic haemodynamics.

scholarly journals Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0224414
Author(s):  
Gabriella Baio ◽  
Marina Fabbi ◽  
Michele Cilli ◽  
Francesca Rosa ◽  
Simona Boccardo ◽  
...  
Keyword(s):  
Potential Role ◽  
Preliminary Results ◽  
Enhanced Mri ◽  
Prostate Cancers ◽  
Calcium Receptors ◽  
Manganese Enhanced Mri
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