Molecular composition of iron oxide nanoparticles, precursors for magnetic drug targeting, as characterized by confocal Raman microspectroscopy

The Analyst ◽  
2005 ◽  
Vol 130 (10) ◽  
pp. 1395 ◽  
Author(s):  
Igor Chourpa ◽  
Laurence Douziech-Eyrolles ◽  
Lazare Ngaboni-Okassa ◽  
Jean-François Fouquenet ◽  
Simone Cohen-Jonathan ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Raman Microspectroscopy ◽  
Molecular Composition ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting

2016 ◽  
Vol 101 ◽  
pp. 152-162 ◽  
Author(s):  
Jan Zaloga ◽  
Marina Pöttler ◽  
Gerd Leitinger ◽  
Ralf P. Friedrich ◽  
Gunter Almer ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Pharmaceutical Formulation ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Magnetic Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy

2016 ◽  
Vol 25 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Bogdan Silviu Ungureanu ◽  
Cristian-Mihail Teodorescu ◽  
Adrian Săftoiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Diagnosis And Treatment ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver, ranking as the second most common cause of death from cancer worldwide. Magnetic nanoparticles (MNPs) have been used so far in tumor diagnosis and treatment, demonstrating great potential and promising results. In principle, three different approaches can be used in the treatment of tumors with superparamagnetic iron oxide nanoparticles: magnetically induced hyperthermia, drug targeting and selective suppression of tumor growth. This review focuses on the use of iron oxide nanoparticles for the diagnosis and treatment of liver cancer and offers a walkthrough from the MNPs imaging applicability to further therapeutic options, including their potential flaws. The MNP unique physical and biochemical properties will be mentioned in close relationship to their subsequent effects on the human body, and, also, their toxic potential will be noted. A presentation of what barriers the MNPs should overcome to be more successful will conclude this review. Abbreviations: AMF: Alternating magnetic field; DOX: Doxorubicin; GD: Gadolinium; HCC: hepatocellular carcinoma; 131I: Iodine 131; MDT: Magnetic drug targeting; ML: Magnetoliposomes; MNP: magnetic nanoparticles; MRI: Magnetic Resonance Imaging; PNIPA: Poly-N-isopropylacrylamide; SPIONS: Superparamagnetic iron oxide nanoparticles; VEGF: Vascular endothelial growth factor.

Visualization and Motion of Curcumin Loaded Iron Oxide Nanoparticles During Magnetic Drug Targeting

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammed Asfer ◽  
Ayodhya Prasad Prajapati ◽  
Arun Kumar ◽  
Pradipta Kumar Panigrahi
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Applied Magnetic Field ◽  
Drug Targeting ◽  
In Vitro Study ◽  
Target Site ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Magnetic drug targeting (MDT) involves the localization of drug loaded iron oxide nanoparticles (IONPs) around the malignant tissue using external magnetic field for therapeutic purposes. The present in vitro study reports the visualization and motion of curcumin loaded IONPs (CU-IONPs) around the target site inside a microcapillary (500 × 500 μm2 square cross section), in the presence of an externally applied magnetic field. Application of magnetic field leads to transportation and aggregation of CU-IONPs toward the target site inside the capillary adjacent to the magnet. The localization/aggregation of CU-IONPs at the target site shows strong dependence on the strength of the applied magnetic field and flow rate of ferrofluid through the capillary. Such an in vitro study offers a viable for optimization and design of MDT systems for in vivo applications.

scholarly journals In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

2020 ◽  
Vol 6 (3) ◽  
pp. 543-546
Author(s):  
Michael Fink ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert ◽  
Stefan Lyer
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Imaging Technique ◽  
Small Animal ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Medical Procedures ◽  
First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

scholarly journals Molecular Composition Of Organelles In A Living Yeast Cell Studied By Confocal Raman Microspectroscopy

2003 ◽  
Vol 9 (S02) ◽  
pp. 1082-1083
Author(s):  
Yu-San Huang ◽  
Takeshi Karashima ◽  
Masayuki Yamamoto ◽  
Hiro-o Hamaguchi
Keyword(s):  
Yeast Cell ◽  
Raman Microspectroscopy ◽  
Molecular Composition ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman
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