A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array

Lab on a Chip ◽  
2005 ◽  
Vol 5 (1) ◽  
pp. 44 ◽  
Author(s):  
Paul J. Hung ◽  
Philip J. Lee ◽  
Poorya Sabounchi ◽  
Nima Aghdam ◽  
Robert Lin ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cell Growth ◽  
Aspect Ratio ◽  
Mammalian Cell ◽  
High Throughput ◽  
High Aspect Ratio ◽  
Mammalian Cell Culture

scholarly journals Dynamic Modeling of Apoptosis and its Interaction with Cell Growth in Mammalian Cell Culture

2011 ◽  
Vol 44 (1) ◽  
pp. 9691-9696 ◽  
Author(s):  
Mukesh Meshram ◽  
Saeideh Naderi ◽  
Yi-Yun Wei ◽  
Brendan McConkey ◽  
Brian Ingalls ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cell Growth ◽  
Mammalian Cell ◽  
Dynamic Modeling ◽  
Mammalian Cell Culture

Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture

2006 ◽  
Vol 122 (3) ◽  
pp. 293-306 ◽  
Author(s):  
Xudong Ge ◽  
Michael Hanson ◽  
Hong Shen ◽  
Yordan Kostov ◽  
Kurt A. Brorson ◽  
...  
Keyword(s):  
Cell Culture ◽  
Mammalian Cell ◽  
High Throughput ◽  
Optical Sensor ◽  
Mammalian Cell Culture ◽  
Bioreactor System

Miniature Bioreactors for Rapid Bioprocess Development of Mammalian Cell Culture

2012 ◽  
Vol 59 (1) ◽  
Author(s):  
Mohd Helmi Sani ◽  
Frank Baganz
Keyword(s):  
Cell Culture ◽  
Mammalian Cell ◽  
Process Development ◽  
Mammalian Cell Culture ◽  
Small Scale ◽  
Cell Culture Process ◽  
Deep Wells ◽  
Working Volume ◽  
Culture Process ◽  
And Control

At present, there are a number of commercial small scale shaken systems available on the market with instrumented controllable microbioreactors such as Micro–24 Microreactor System (Pall Corporation, Port Washington, NY) and M2P Biolector, (M2P Labs GmbH, Aachen, Germany). The Micro–24 system is basically an orbital shaken 24–well plate that operates at working volume 3 – 7 mL with 24 independent reactors (deep wells, shaken and sparged) running simultaneously. Each reactor is designed as single use reactor that has the ability to continuously monitor and control the pH, DO and temperature. The reactor aeration is supplied by sparging air from gas feeds that can be controlled individually. Furthermore, pH can be controlled by gas sparging using either dilute ammonia or carbon dioxide directly into the culture medium through a membrane at the bottom of each reactor. Chen et al., (2009) evaluated the Micro–24 system for the mammalian cell culture process development and found the Micro–24 system is suitable as scaledown tool for cell culture application. The result showed that intra-well reproducibility, cell growth, metabolites profiles and protein titres were scalable with 2 L bioreactors.

Lecithin blended polyamide-6 high aspect ratio nanofiber scaffolds via electrospinning for human osteoblast cell culture

2011 ◽  
Vol 31 (2) ◽  
pp. 486-493 ◽  
Author(s):  
R. Nirmala ◽  
Hye-Min Park ◽  
R. Navamathavan ◽  
Hyung-Sub Kang ◽  
Mohamed H. El-Newehy ◽  
...  
Keyword(s):  
Cell Culture ◽  
Aspect Ratio ◽  
High Aspect Ratio ◽  
Polyamide 6 ◽  
Human Osteoblast ◽  
Osteoblast Cell ◽  
Human Osteoblast Cell ◽  
Nanofiber Scaffolds

scholarly journals Arrays of high-aspect ratio microchannels for high-throughput isolation of circulating tumor cells (CTCs)

2013 ◽  
Vol 20 (10-11) ◽  
pp. 1815-1825 ◽  
Author(s):  
Mateusz L. Hupert ◽  
Joshua M. Jackson ◽  
Hong Wang ◽  
Małgorzata A. Witek ◽  
Joyce Kamande ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
High Throughput ◽  
High Aspect Ratio

Adaptation of an insect cell line (Agallia constricta) in a mammalian cell culture medium

In Vitro ◽  
1973 ◽  
Vol 8 (5) ◽  
pp. 375-378 ◽  
Author(s):  
Arthur H. Intosh ◽  
K. Maramorosch ◽  
C. Rechtoris
Keyword(s):  
Cell Culture ◽  
Cell Line ◽  
Mammalian Cell ◽  
Insect Cell ◽  
Culture Medium ◽  
Mammalian Cell Culture ◽  
Insect Cell Line ◽  
Cell Culture Medium
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