Calix[4]arene methylenebisphosphonic acids as calf intestine alkaline phosphatase inhibitors

2004 ◽  
Vol 2 (21) ◽  
pp. 3162 ◽  
Author(s):  
Andriy I. Vovk ◽  
Vitaly I. Kalchenko ◽  
Sergey A. Cherenok ◽  
Valery P. Kukhar ◽  
Oxana V. Muzychka ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Inhibitors ◽  
Calf Intestine Alkaline Phosphatase ◽  
Intestine Alkaline Phosphatase

scholarly journals Synthesis of new Cadmium(II) Complexes of Schiff Bases as Alkaline Phosphatase Inhibitors and their Antimicrobial Activity

2021 ◽  
pp. 103308
Author(s):  
Rana Muhammad Irfan ◽  
Muhammad Ashraf Shaheen ◽  
Muhammad Saleem ◽  
Muhammad Nawaz Tahir ◽  
Khurram Shahzad Munawar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Alkaline Phosphatase ◽  
Schiff Bases ◽  
Phosphatase Inhibitors

scholarly journals Inhibition studies of alkaline phosphatase in hard tissue-forming cells.

1975 ◽  
Vol 23 (5) ◽  
pp. 342-347 ◽  
Author(s):  
A Linde ◽  
B C Magnusson
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Adenosine Triphosphatase ◽  
Ruthenium Red ◽  
Inorganic Pyrophosphatase ◽  
Alkaline Ph ◽  
Hard Tissue ◽  
Assay Condition ◽  
Phosphatase Inhibitors ◽  
Inhibition Studies

The effects of the alkaline phosphatase inhibitors levamisole and R 8231 on p-nitro-phenylphosphatase, inorganic pyrophosphatase and adenosine triphosphatase (ATPase) activities in dentingenically active odontoblasts were studied. The p-nitrophenylphosphatase and inorganic pyrophosphatase activities were inhibited, while 40% of the ATP-splitting enzyme activity remained under the assay condition used. This finding, togeather with earlier studies, indicates that at least two different phosphatase are active at alkaline pH in hard tissue-forming cells; on nonspecific alkaline phosphatase and one specific ATPase. The ATPase activity is uninfluenced by ouabain and ruthenium red and is activated by Ca-2+ ions.

Synthesis, In Vitro, and In Silico Studies of N-(Substituted-Phenyl)-3-(4-Phenyl-1-Piperazinyl)propanamides as Potent Alkaline Phosphatase Inhibitors

2021 ◽  
Vol 47 (5) ◽  
pp. 1086-1096
Author(s):  
M. A. Abbasi ◽  
M. Nazir ◽  
Aziz-ur-Rehman ◽  
S. Z. Siddiqui ◽  
Hussain Raza ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
In Silico ◽  
Phosphatase Inhibitors ◽  
In Silico Studies

ChemInform Abstract: Diversity Oriented Synthesis of 6-Nitro- and 6-Aminoquinolones and Their Activity as Alkaline Phosphatase Inhibitors.

ChemInform ◽  
2015 ◽  
Vol 46 (50) ◽  
pp. no-no
Author(s):  
Mariia Miliutina ◽  
Anton Ivanov ◽  
Syeda Abida Ejaz ◽  
Jamshed Iqbal ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Diversity Oriented Synthesis ◽  
Phosphatase Inhibitors

Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies

RSC Advances ◽  
2015 ◽  
Vol 5 (79) ◽  
pp. 64404-64413 ◽  
Author(s):  
Imtiaz Khan ◽  
Syed Jawad Ali Shah ◽  
Syeda Abida Ejaz ◽  
Aliya Ibrar ◽  
Shahid Hameed ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Carboxylic Acid ◽  
Molecular Modelling ◽  
Phosphatase Inhibitors ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Sar Analysis

The present study is directed towards the development of quinoline-4-carboxylic acid derivatives as potential alkaline phosphatase inhibitors.

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