Kinetic and synthetic influences of water and solvent-free conditions on 1,3-dipolar cycloaddition reactions: the phthalazinium and pyridazinium dicyanomethanide 1,3-dipoles: surprisingly successful synthetic methodsElectronic supplementary information (ESI) available: sample kinetic graphs and optimised transition state structures. See http://www.rsc.org/suppdata/p2/b2/b206028k/

2002 ◽  
pp. 1807-1815 ◽  
Author(s):  
Richard N. Butler ◽  
Anthony G. Coyne ◽  
William J. Cunningham ◽  
Luke A. Burke
Keyword(s):  
Transition State ◽  
Solvent Free ◽  
Supplementary Information ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
Solvent Free Conditions ◽  
Transition State Structures

scholarly journals Solvent-free one-pot 1,3-Dipolar cycloaddition reactions of dihydropyran derived nitrone

2012 ◽  
Vol 124 (3) ◽  
pp. 679-685 ◽  
Author(s):  
BHASKAR CHAKRABORTY ◽  
PRAWIN KUMAR SHARMA ◽  
NEELAM RAI ◽  
CHIRAN DEVI SHARMA
Keyword(s):  
Solvent Free ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
One Pot

1,3-Dipolar Cycloaddition of Nitriles under Microwave Irradiation in Solvent-Free Conditions

Heterocycles ◽  
1996 ◽  
Vol 43 (5) ◽  
pp. 1021 ◽  
Author(s):  
Angel Díaz-Ortiz ◽  
Enrique Díez-Barra ◽  
Antonio de la Hoz ◽  
Andrés Moreno ◽  
Maria J. Gómez-Escalonilla ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solvent Free ◽  
Dipolar Cycloaddition ◽  
Solvent Free Conditions

scholarly journals Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

2018 ◽  
Vol 14 ◽  
pp. 2689-2697 ◽  
Author(s):  
Robby Vroemans ◽  
Yenthel Verhaegen ◽  
My Tran Thi Dieu ◽  
Wim Dehaen
Keyword(s):  
Multicomponent Reaction ◽  
Mechanochemical Synthesis ◽  
Solvent Free ◽  
Viable Alternative ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Biologically Relevant ◽  
Metal Free ◽  
Organic Azides ◽  
Solvent Free Conditions

A new metal-free one-pot three-component procedure towards fully substituted triazolochromenes has been developed, starting from commercially available materials. Salicylaldehydes and nitroalkenes were reacted under solvent-free conditions, followed by a 1,3-dipolar cycloaddition of the intermediate 3-nitro-2H-chromenes with organic azides in a one-pot two-step sequence. The triazolochromenes were formed with complete regioselectivity and new biologically relevant structures were synthesized via extension of the developed procedure and via postfunctionalization. The mechanochemical synthesis was carried out for several salicylaldehydes and gave a clear improvement in the yield of the corresponding triazolochromenes and consequently showed to be a viable alternative for solid salicylaldehydes.

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