scholarly journals Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

2018 ◽  
Vol 14 ◽  
pp. 2689-2697 ◽  
Author(s):  
Robby Vroemans ◽  
Yenthel Verhaegen ◽  
My Tran Thi Dieu ◽  
Wim Dehaen
Keyword(s):  
Multicomponent Reaction ◽  
Mechanochemical Synthesis ◽  
Solvent Free ◽  
Viable Alternative ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Biologically Relevant ◽  
Metal Free ◽  
Organic Azides ◽  
Solvent Free Conditions

A new metal-free one-pot three-component procedure towards fully substituted triazolochromenes has been developed, starting from commercially available materials. Salicylaldehydes and nitroalkenes were reacted under solvent-free conditions, followed by a 1,3-dipolar cycloaddition of the intermediate 3-nitro-2H-chromenes with organic azides in a one-pot two-step sequence. The triazolochromenes were formed with complete regioselectivity and new biologically relevant structures were synthesized via extension of the developed procedure and via postfunctionalization. The mechanochemical synthesis was carried out for several salicylaldehydes and gave a clear improvement in the yield of the corresponding triazolochromenes and consequently showed to be a viable alternative for solid salicylaldehydes.

Ionic Liquid Catalyzed Efficient Regioselective Synthesis of 1,4- Disubstituted 1,2,3-Triazoles under Metal and Solvent free Conditions

2020 ◽  
Vol 07 ◽  
Author(s):  
Abid H. Banday ◽  
Victor J. Hruby
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Solvent Free ◽  
Regioselective Synthesis ◽  
Chromatographic Separations ◽  
One Pot ◽  
Green Protocol ◽  
Metal Free ◽  
Organic Azides ◽  
Solvent Free Conditions

Background: Unprecedented, one-pot regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles through azide- aldehyde (3+2) organo-click cycloaddition under metal and solvent-free conditions, is described. Objective: Solvent and metal free synthesis of biologically and industrially important triazoles. Methods: Efficient and high yielding synthesis of products avoiding the tedious high solvent workups and chromatographic separations. The synthesis doesn’t involve the routine acetylenes which are very costly but instead cheaper starting materials like aldehydes and organic azides are used. Results: Green protocol based on the catalysis through Ionic Liquids which simultaneously act as solvents. The products are obtained in good to excellent yields in hassle free synthesis. Conclusion: Efficient and green synthesis of structurally and biologically important triazoles.

A facile and highly convergent approach to thiazolo[3,2-a]pyridines via one-pot multicomponent domino reaction under metal-free and solvent-free conditions

Tetrahedron ◽  
2015 ◽  
Vol 71 (21) ◽  
pp. 3422-3427 ◽  
Author(s):  
Anugula Nagaraju ◽  
B. Janaki Ramulu ◽  
Gaurav Shukla ◽  
Abhijeet Srivastava ◽  
Girijesh Kumar Verma ◽  
...  
Keyword(s):  
Solvent Free ◽  
Domino Reaction ◽  
One Pot ◽  
Metal Free ◽  
Solvent Free Conditions ◽  
Convergent Approach

scholarly journals Retracted Article: An efficient one pot three-component synthesis of 2,4,6-triarylpyridines using triflimide as a metal-free catalyst under solvent-free conditions

RSC Advances ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 5158-5163 ◽  
Author(s):  
Hongshe Wang ◽  
Weixing Zhao ◽  
Juan Du ◽  
Fenyan Wei ◽  
Qi Chen ◽  
...  
Keyword(s):  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Metal Free ◽  
Effective Catalyst ◽  
Solvent Free Conditions ◽  
Retracted Article

A simple and efficient protocol developed for one pot three-component synthesis of 2,4,6-triarylpyridines from aromatic aldehydes, substituted acetophenones and ammonium acetate using triflimide (HNTf2) as an effective catalyst is described.

Nano zirconia catalysed one-pot synthesis of some novel substituted imidazoles under solvent-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28163-28170 ◽  
Author(s):  
Shivam Bajpai ◽  
Sundaram Singh ◽  
Vandana Srivastava
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Method ◽  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Isatin Derivatives

A highly efficient method for the synthesis of substituted imidazoles from a multicomponent reaction of isatin derivatives with ammonium acetate and aromatic aldehydes under solvent-free conditions has been established.

ChemInform Abstract: A Facile and Highly Convergent Approach to Thiazolo[3,2-a]pyridines via One-Pot Multicomponent Domino Reaction under Metal-Free and Solvent-Free Conditions.

ChemInform ◽  
2015 ◽  
Vol 46 (37) ◽  
pp. no-no
Author(s):  
Anugula Nagaraju ◽  
B. Janaki Ramulu ◽  
Gaurav Shukla ◽  
Abhijeet Srivastava ◽  
Girijesh Kumar Verma ◽  
...  
Keyword(s):  
Solvent Free ◽  
Domino Reaction ◽  
One Pot ◽  
Metal Free ◽  
Solvent Free Conditions ◽  
Convergent Approach
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