Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4Electronic supplementry information (ESI) available: mode of epoxide ring-opening and experimental data for 2 and 3. See http://www.rsc.org/suppdata/p1/b2/b204891d/

2002 ◽  
pp. 1625-1627 ◽  
Author(s):  
Stuart J. Conway ◽  
Jacqueline C. Miller ◽  
Andrew D. Bond ◽  
Barry P. Clark ◽  
David E. Jane
Keyword(s):  
Experimental Data ◽  
Glutamate Receptor ◽  
Ring Opening ◽  
Receptor Agonist ◽  
Biological Evaluation ◽  
Epoxide Ring ◽  
Epoxide Ring Opening ◽  
Glutamate Receptor Agonist ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-β-lactams Through Stereo- and Regioselective Epoxide Ring Opening.

ChemInform ◽  
2007 ◽  
Vol 38 (12) ◽  
Author(s):  
Fides Benfatti ◽  
Giuliana Cardillo ◽  
Luca Gentilucci ◽  
Rossana Perciaccante ◽  
Alessandra Tolomelli ◽  
...  
Keyword(s):  
Ring Opening ◽  
Biological Evaluation ◽  
Epoxide Ring ◽  
Epoxide Ring Opening ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-β-lactams through Stereo- and Regioselective Epoxide Ring Opening†

2006 ◽  
Vol 71 (24) ◽  
pp. 9229-9232 ◽  
Author(s):  
Fides Benfatti ◽  
Giuliana Cardillo ◽  
Luca Gentilucci ◽  
Rossana Perciaccante ◽  
Alessandra Tolomelli ◽  
...  
Keyword(s):  
Ring Opening ◽  
Biological Evaluation ◽  
Epoxide Ring ◽  
Epoxide Ring Opening ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Synthesis and Biological Evaluation of Phospholane and Dihydrophosphole Analogues of the Glutamate Receptor Agonist AP4.

ChemInform ◽  
2010 ◽  
Vol 33 (47) ◽  
pp. no-no
Author(s):  
Stuart J. Conway ◽  
Jacqueline C. Miller ◽  
Andrew D. Bond ◽  
Barry P. Clark ◽  
David E. Jane
Keyword(s):  
Glutamate Receptor ◽  
Receptor Agonist ◽  
Biological Evaluation ◽  
Glutamate Receptor Agonist ◽  
Synthesis And Biological Evaluation

Bimetallic Radical Redox-Relay Catalysis for the Isomerization of Epoxides to Allylic Alcohols

2019 ◽  
Author(s):  
Ke-Yin Ye ◽  
Terry McCallum ◽  
Song Lin
Keyword(s):  
Ring Opening ◽  
High Reactivity ◽  
Hydrogen Atom Transfer ◽  
Organic Radicals ◽  
Epoxide Ring ◽  
Allylic Alcohols ◽  
Epoxide Ring Opening ◽  
Bond Forming ◽  
Co Catalysts ◽  
The Rich

Organic radicals are generally short-lived intermediates with exceptionally high reactivity. Strategically, achieving synthetically useful transformations mediated by organic radicals requires both efficient initiation and selective termination events. Here, we report a new catalytic strategy, namely bimetallic radical redox-relay, in the regio- and stereoselective rearrangement of epoxides to allylic alcohols. This approach exploits the rich redox chemistry of Ti and Co complexes and merges reductive epoxide ring opening (initiation) with hydrogen atom transfer (termination). Critically, upon effecting key bond-forming and -breaking events, Ti and Co catalysts undergo proton-transfer/electron-transfer with one another to achieve turnover, thus constituting a truly synergistic dual catalytic system.<br>

Construction the A-B bicyclic ring structure of Stemocurtisisne

2020 ◽  
Vol 17 ◽  
Author(s):  
Duc Dau Xuan
Keyword(s):  
Glutamic Acid ◽  
Natural Product ◽  
Mannich Reaction ◽  
Boronic Acid ◽  
Ring Opening ◽  
Ring Structure ◽  
Starting Material ◽  
Epoxide Ring ◽  
Epoxide Ring Opening

: The synthesis of the A-B bicyclic ring structure 3 of the natural product Stemocurtisine is described. The synthesis was accomplished in seven synthetic steps from commercially available L-glutamic acid. The key step involved a borono-Mannich reaction between the hemiaminal 6 and trans-β-styryl boronic acid and trans-β-styrylpotassiumtrifluoroborate to prepare the cis diene 4. Attempts to prepare the A-B-C ring compound 2 via intramolecular epoxide ring opening followed by rearangement under different basic conditions were unsuccessful. Only unreactive starting material was recovered.

scholarly journals Thermal and Electrochemical Properties of Solid Polymer Electrolytes Prepared via Lithium Salt-Catalyzed Epoxide Ring Opening Polymerization

2021 ◽  
Vol 11 (4) ◽  
pp. 1561
Author(s):  
Gabrielle Foran ◽  
Nina Verdier ◽  
David Lepage ◽  
Arnaud Prébé ◽  
David Aymé-Perrot ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Polymer Electrolytes ◽  
Ring Opening ◽  
Lithium Salt ◽  
Ring Opening Polymerization ◽  
Solid Polymer Electrolytes ◽  
Solid Polymer ◽  
Polymerization Reaction ◽  
Epoxide Ring ◽  
Epoxide Ring Opening

Solid polymer electrolytes have been widely proposed for use in all solid-state lithium batteries. Advantages of polymer electrolytes over liquid and ceramic electrolytes include their flexibility, tunability and easy processability. An additional benefit of using some types of polymers for electrolytes is that they can be processed without the use of solvents. An example of polymers that are compatible with solvent-free processing is epoxide-containing precursors that can form films via the lithium salt-catalyzed epoxide ring opening polymerization reaction. Many polymers with epoxide functional groups are liquid under ambient conditions and can be used to directly dissolve lithium salts, allowing the reaction to be performed in a single reaction vessel under mild conditions. The existence of a variety of epoxide-containing polymers opens the possibility for significant customization of the resultant films. This review discusses several varieties of epoxide-based polymer electrolytes (polyethylene, silicone-based, amine and plasticizer-containing) and to compare them based on their thermal and electrochemical properties.

Anti-epileptogenic and anticonvulsant activity of l-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist

1997 ◽  
Vol 755 (2) ◽  
pp. 202-212 ◽  
Author(s):  
Abdul-Salam Abdul-Ghani ◽  
Philip J.E Attwell ◽  
Natasha Singh Kent ◽  
Henry F Bradford ◽  
Martin J Croucher ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Anticonvulsant Activity ◽  
Receptor Agonist ◽  
Glutamate Receptor Agonist
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