Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug designElectronic supplementary information (ESI) available: diagram showing sulfur link, UV melting curves, sample PE-COSY spectra, further NOE intensity data. See: http://www.rsc.org/suppdata/cc/b2/b203582k/

2002 ◽  
pp. 1458-1459 ◽  
Author(s):  
Andrew P. G. Beevers ◽  
Kevin J. Fettes ◽  
Ian A. O’Neil ◽  
Stanley M. Roberts ◽  
John R. P. Arnold ◽  
...  
Keyword(s):  
Supplementary Information ◽  
Intensity Data ◽  
Melting Curves ◽  
Uv Melting ◽  
Cosy Spectra

Thermodynamics of the various forms of the dodecamer d(ATTACCGGTAAT) and of its constituent hexamers from proton nmr chemical shifts and UV melting curves: Three-state and four-state thermodynamic models

Biopolymers ◽  
1989 ◽  
Vol 28 (3) ◽  
pp. 717-740 ◽  
Author(s):  
Jane M. L. Pieters ◽  
Jan-Remt Mellema ◽  
Hans Van Den Elst ◽  
Gijs A. Van Der Marel ◽  
Jacques H. Van Boom ◽  
...  
Keyword(s):  
Chemical Shifts ◽  
Proton Nmr ◽  
Thermodynamic Models ◽  
Nmr Chemical Shifts ◽  
Melting Curves ◽  
Uv Melting

Direct phase determination in electron crystallography: small organic molecules

1992 ◽  
Vol 50 (2) ◽  
pp. 1166-1167
Author(s):  
Douglas L. Dorset
Keyword(s):  
Organic Molecules ◽  
Data Sets ◽  
Temperature Structure ◽  
3D Analysis ◽  
Intensity Data ◽  
Electron Crystallography ◽  
Phase Determination ◽  
Measured Intensity ◽  
3D Data

The quantitative use of electron diffraction intensity data for the determination of crystal structures represents the pioneering achievement in the electron crystallography of organic molecules, an effort largely begun by B. K. Vainshtein and his co-workers. However, despite numerous representative structure analyses yielding results consistent with X-ray determination, this entire effort was viewed with considerable mistrust by many crystallographers. This was no doubt due to the rather high crystallographic R-factors reported for some structures and, more importantly, the failure to convince many skeptics that the measured intensity data were adequate for ab initio structure determinations.We have recently demonstrated the utility of these data sets for structure analyses by direct phase determination based on the probabilistic estimate of three- and four-phase structure invariant sums. Examples include the structure of diketopiperazine using Vainshtein's 3D data, a similar 3D analysis of the room temperature structure of thiourea, and a zonal determination of the urea structure, the latter also based on data collected by the Moscow group.

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