Report of the Sub-Committee on the determination of unsaponifiable matter in oils and fats and of unsaponified fat in soaps to the Analytical Methods Committee of the Society of Public Analysts. Report No. 2. The determination of unsaponified fat in soaps

Musty odor has occurred annually in Lake Biwa since 1969. Osaka municipal waterworks, which is located downstream of Lake Biwa, has made many efforts to treat musty-odor compounds produced in Lake Biwa from spring through autumn. With the development of analytical methods for the determination of musty-odor compounds, we have been able to confirm that planktonic blue-green algae are the major causes of the musty-odor occurrences. The relationship between the growth of blue-green algae and the water quality was not so apparent. However, through our data analysis focusing on the relationship between musty-odor occurrences due to Phormidium tenue or Oscillatoria tenuis and some nutrients in Lake Biwa, we found that the concentration of nitrate in water may be an important parameter for the estimation of growth of the algae and the musty-odor behavior.

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A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

Current Pharmaceutical Analysis ◽

10.2174/1573412916666191025143214 ◽

2020 ◽

Vol 17 (1) ◽

pp. 31-39

Author(s):

Marilene Lopes Ângelo ◽

Fernanda de Lima Moreira ◽

Ana Laura Araújo Santos ◽

Hérida Regina Nunes Salgado ◽

Magali Benjamim de Araújo

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Analytical Methods ◽

Estrogenic Activity ◽

Biological Fluids ◽

Pharmaceutical Formulations ◽

Doping Control ◽

Specific Effects ◽

In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

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Electroanalysis of Tricyclic Psychotropic Drugs using Modified Electrodes

Current Analytical Chemistry ◽

10.2174/1573411014666180917112548 ◽

2019 ◽

Vol 15 (4) ◽

pp. 423-442 ◽

Cited By ~ 1

Author(s):

Mona Habibi-Kool-Gheshlaghi ◽

Farnoush Faridbod ◽

Mahya Karami Mosammam ◽

Mohammad Reza Ganjali

Keyword(s):

Psychotropic Drugs ◽

Analytical Methods ◽

Electrochemical Techniques ◽

Modified Electrodes ◽

Electroanalytical Methods ◽

Drug Assays ◽

Medical Importance ◽

Tricyclic Rings ◽

Easy Operation

Background: Tricyclic psychotropic drugs are defined as a tricyclic rings of the dibenzazepine group with the presence of sulfur and nitrogen atoms. They have been prescribed for antidepressive therapy over the years. Due to their medical importance, many analytical methods have been developed for their monitoring. However, benefits of electrochemical techniques such as costeffectiveness, fast, easy operation and non-destructiveness make them appropriate analytical methods for drug assays. Electrochemical determinations of pharmaceuticals require suitable working electrodes. During years, many electrodes are modified by a variety of modifiers and several sensors were developed based on them. In this regard, nanomaterials, due to their remarkable properties, are one of the most important choices. Objective: Here, the application of electroanalytical methods in the determination of electroactive tricyclic psychotropic drugs will be reviewed and the nanomaterials which are used for improvements of the working electrodes will be considered.

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