Influence of functional and cross-linking monomers and the amount of template on the performance of molecularly imprinted polymers in binding assays

1999 ◽  
Vol 36 (5) ◽  
pp. 167-170 ◽  
Author(s):  
Ecevit Yilmaz ◽  
Klaus Mosbach ◽  
Karsten Haupt
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Cross Linking ◽  
Binding Assays ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Synthesis of Molecularly Imprinted Polymer via Emulsion Polymerization for Application in Solanesol Separation

2020 ◽  
Vol 10 (8) ◽  
pp. 2868 ◽  
Author(s):  
Guojie Zhao ◽  
Jing Liu ◽  
Minghong Liu ◽  
Xiaobin Han ◽  
Yulong Peng ◽  
...  
Keyword(s):  
Emulsion Polymerization ◽  
Molecularly Imprinted Polymers ◽  
Current Method ◽  
Synthesis Process ◽  
Cross Linking ◽  
Adsorption Effect ◽  
Synthesis Time ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Synthesis Conditions

High-purity solanesol can be used for pharmaceutical applications, but the current method for purifying solanesol has high cost and difficult continuous operation, and the use of molecular imprinting to purify natural products is a hot research topic of current research. Solanesol molecularly imprinted polymers were synthesized via emulsion polymerization for the first time. The morphology of the SSO-MIPs was observed with a scanning electron microscope, and the effects of the synthesis time, initiator dosage, functional monomer dosage, and cross-linking agent dosage on the adsorption effects under high-temperature and rapid synthesis conditions were discussed. The results demonstrate that the optimum synthesis conditions were a ratio of the template molecules to the functional monomers to the cross-linking agents of 1:8:30 (mol:mol:mol), 10 mg of the initiator, and a synthesis temperature of 70 °C. The imprinting factor of SSO-MIPs synthesized under the optimized process was found to reach 2.51, and the SSO-MIPs synthesized by this method exhibited a good adsorption effect, emitted less pollution during the synthesis process, and are convenient for demulsification. This research reports a reliable method for the synthesis of solanesol molecularly imprinted polymers.

scholarly journals The Selectivity of Molecularly Imprinted Polymers

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1781
Author(s):  
Gergely Becskereki ◽  
George Horvai ◽  
Blanka Tóth
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Practical Method ◽  
Batch Adsorption ◽  
Phase Extraction ◽  
Target Compound ◽  
Binding Assays ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

The general claim about novel molecularly imprinted polymers is that they are selective for their template or for another target compound. This claim is usually proved by some kind of experiment, in which a performance parameter of the imprinted polymer is shown to be better towards its template than towards interferents. A closer look at such experiments shows, however, that different experiments may differ substantially in what they tell about the same imprinted polymer’s selectivity. Following a short general discussion of selectivity concepts, the selectivity of imprinted polymers is analyzed in batch adsorption, binding assays, chromatography, solid phase extraction, sensors, membranes, and catalysts. A number of examples show the problems arising with each type of application. Suggestions for practical method design are provided.

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