An improved, easy and efficient method for the generation of nitrile oxides from nitronates for in situ 1,3-dipolar cycloaddition

1999 ◽  
pp. 1215 ◽  
Author(s):  
ing-Yuan Liu ◽  
Ming-Chung Yan ◽  
Wen-Wei Lin ◽  
Lian-Yong Wang ◽  
Ching-Fa Yao
Keyword(s):  
Efficient Method ◽  
Dipolar Cycloaddition ◽  
Nitrile Oxides

ChemInform Abstract: An Improved, Easy and Efficient Method for the Generation of Nitrile Oxides from Nitronates for in situ 1,3-Dipolar Cycloaddition.

ChemInform ◽  
2010 ◽  
Vol 30 (38) ◽  
pp. no-no
Author(s):  
Jing-Yuan Liu ◽  
Ming-Chung Yan ◽  
Wen-Wei Lin ◽  
Lian-Yong Wang ◽  
Ching-Fa Yao
Keyword(s):  
Efficient Method ◽  
Dipolar Cycloaddition ◽  
Nitrile Oxides

Asymmetric 1,3-Dipolar Cycloaddition of Nitrile Oxides Generated in situ by Direct Oxidation of Aldoximes

2002 ◽  
Vol 31 (11) ◽  
pp. 1112-1113 ◽  
Author(s):  
Masamichi Tsuji ◽  
Yutaka Ukaji ◽  
Katsuhiko Inomata
Keyword(s):  
Dipolar Cycloaddition ◽  
Direct Oxidation ◽  
Nitrile Oxides

An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

2010 ◽  
Vol 8 (11) ◽  
pp. 2537 ◽  
Author(s):  
Christian Spiteri ◽  
Christopher Mason ◽  
Fengzhi Zhang ◽  
Dougal J. Ritson ◽  
Pallavi Sharma ◽  
...  
Keyword(s):  
Dipolar Cycloaddition ◽  
Nitrile Oxides

In Situ Generation of Nitrile Oxides from NaCl–Oxone Oxidation of Various Aldoximes and Their 1,3-Dipolar Cycloaddition

2018 ◽  
Vol 21 (1) ◽  
pp. 315-319 ◽  
Author(s):  
Guodong Zhao ◽  
Lixin Liang ◽  
Chi Ho Ethan Wen ◽  
Rongbiao Tong
Keyword(s):  
Dipolar Cycloaddition ◽  
Nitrile Oxides ◽  
In Situ Generation

scholarly journals Isoxazole derivatives as new nitric oxide elicitors in plants

2017 ◽  
Vol 13 ◽  
pp. 659-664 ◽  
Author(s):  
Anca Oancea ◽  
Emilian Georgescu ◽  
Florentina Georgescu ◽  
Alina Nicolescu ◽  
Elena Iulia Oprita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Dipolar Cycloaddition ◽  
Oxygen Species ◽  
Cycloaddition Reactions ◽  
Nitrile Oxides ◽  
Activated Alkynes ◽  
Isoxazole Derivatives

Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated alkynes in the presence of catalytic amounts of copper(I) iodide. Effects of 3,5-disubstituted isoxazoles on nitric oxide and reactive oxygen species generation in Arabidopsis tissues was studied using specific diaminofluoresceine dyes as fluorescence indicators.

ChemInform Abstract: An Efficient Entry to 1,2-Benzisoxazoles via 1,3-Dipolar Cycloaddition of in situ Generated Nitrile Oxides and Benzyne.

ChemInform ◽  
2010 ◽  
Vol 41 (43) ◽  
pp. no-no
Author(s):  
Christian Spiteri ◽  
Christopher Mason ◽  
Fengzhi Zhang ◽  
Dougal J. Ritson ◽  
Pallavi Sharma ◽  
...  
Keyword(s):  
Dipolar Cycloaddition ◽  
Nitrile Oxides

Synthesis of isoxazole conjugates of sugars via 1,3-dipolar cycloaddition

2008 ◽  
Vol 86 (2) ◽  
pp. 138-141 ◽  
Author(s):  
Vipraja V Vaidya ◽  
Karuna S Wankhede ◽  
Manikrao M Salunkhe ◽  
Girish K Trivedi
Keyword(s):  
Click Chemistry ◽  
Dipolar Cycloaddition ◽  
Dipolar Cycloadditions ◽  
Nitrile Oxides ◽  
High Degree

Isoxazole conjugates of sugar have been synthesized by the aid of 1,3-dipolar cycloaddition in a click chemistry approach. The sugar-derived propargyl ethers underwent 1,3-dipolar cycloadditions smoothly with in situ generated nitrile oxides from aromatic oximes in good yields. The reaction exhibited a high degree of regioselectivity.Key words: isoxazole conjugates, 1,3-dipolar cycloadditions, nitrile oxides.

Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

2011 ◽  
Vol 64 (10) ◽  
pp. 1397 ◽  
Author(s):  
Malte Brasholz ◽  
Simon Saubern ◽  
G. Paul Savage
Keyword(s):  
Continuous Flow ◽  
Reaction Times ◽  
Nitro Compounds ◽  
Dipolar Cycloaddition ◽  
Flow Conditions ◽  
Nitrile Oxides ◽  
Aliphatic Nitrile ◽  
By Products ◽  
Flow Techniques

Aliphatic nitrile oxides were generated in situ, by dehydration of terminal nitro compounds, and reacted with dipolarophiles using continuous flow techniques to afford substituted isoxazolines. The yields of cycloadducts were comparable with traditional flask-based reactions but reaction times were much shorter. In-line scavenger cartridges conveniently removed by-products and unreacted reagents to give almost pure crude products. The process was demonstrated up to gram scale.

scholarly journals Dearomative [3 + 2] cycloaddition reaction of nitrobenzothiophenes with nonstabilized azomethine ylides

RSC Advances ◽  
2020 ◽  
Vol 10 (48) ◽  
pp. 28720-28724 ◽  
Author(s):  
Kai-Kai Wang ◽  
Yan-Xin Xie ◽  
Yan-Li Li ◽  
Rongxiang Chen ◽  
Zhan-Yong Wang
Keyword(s):  
Efficient Method ◽  
Cycloaddition Reaction ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition

A simple and efficient method for the synthesis of benzo[4,5]thieno[2,3-c]pyrroles via dearomative [3 + 2] 1,3-dipolar cycloaddition reaction of nitrobenzothiophenes with an in situ-generated nonstabilized azomethine ylides have been developed.

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